| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 200,336 | 616,024 | +415,688 | 1.57 | 3.96 | +2.38 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 4,974,289 | 5,098,904 | +124,615 | 0.82 | 0.73 | -0.09 | buy |
| Siren, L.L.C. | 563,314 | 653,721 | +90,407 | 6.33 | 5.34 | -0.99 | buy |
| Artisan Partners Limited Partnership | 199,838 | 279,648 | +79,810 | 0.07 | 0.08 | +0.01 | buy |
| M&G Plc | 173,075 | 193,163 | +20,088 | 0.14 | 0.22 | +0.08 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 11,874 | 27,923 | +16,049 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 16,848 | 21,166 | +4,318 | 0.03 | 0.03 | -0.01 | buy |
| BARINGS LLC | 67,998 | 71,422 | +3,424 | 0.36 | 0.31 | -0.04 | buy |
| AIA Group Ltd | 21,665 | 24,587 | +2,922 | 0.13 | 0.11 | -0.02 | buy |
| Hudson Bay Capital Management LP | 5,000 | 7,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 6,011 | 8,442 | +2,431 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 978 | 2,974 | +1,996 | 0.04 | 0.11 | +0.08 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 74,548 | 76,048 | +1,500 | 0.72 | 0.57 | -0.15 | buy |
| Capital International Sarl | 151,742 | 152,710 | +968 | 0.88 | 0.65 | -0.22 | buy |
| China Universal Asset Management Co., Ltd. | 8,510 | 9,403 | +893 | 0.21 | 0.16 | -0.05 | buy |
| Capital Group Investment Management Pte. Ltd. | 16,030 | 16,436 | +406 | 0.72 | 0.58 | -0.15 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 300 | 691 | +391 | 0.01 | 0.03 | +0.02 | buy |
| LVW Advisors, LLC | 1,001 | 1,132 | +131 | 0.03 | 0.03 | -0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 1,648 | 1,652 | +4 | 0.01 | 0.01 | -0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 9,375 | 9,374 | -1 | 4.11 | 3.94 | -0.17 | sell |
| RICHARDSON FINANCIAL SERVICES INC. | 6 | 2 | -4 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Wealth, LLC | 1,668 | 1,663 | -5 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,979 | 1,940 | -39 | 0.21 | 0.15 | -0.06 | sell |
| NEOS Investment Management LLC | 6,438 | 6,249 | -189 | 0.04 | 0.03 | -0.02 | sell |
| Financial Perspectives, Inc | 869 | 588 | -281 | 0.07 | 0.04 | -0.03 | sell |
| Compagnie Lombard Odier SCmA | 407 | 0 | -407 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 2,637 | 2,010 | -627 | 0.35 | 0.25 | -0.10 | sell |
| ABN AMRO INVESTMENT SOLUTIONS | 26,104 | 24,408 | -1,696 | 0.10 | 0.08 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,582 | 9,786 | -1,796 | 0.02 | 0.01 | -0.01 | sell |
| Nan Fung Group Holdings Ltd | 23,022 | 19,997 | -3,025 | 4.45 | 3.16 | -1.29 | sell |
| EFG Asset Management (North America) Corp. | 13,475 | 9,986 | -3,489 | 0.51 | 0.25 | -0.25 | sell |
| Exome Asset Management LLC | 15,300 | 10,000 | -5,300 | 2.32 | 1.39 | -0.93 | sell |
| XY Capital Ltd | 30,464 | 24,603 | -5,861 | 3.69 | 5.07 | +1.38 | sell |
| Long Corridor Asset Management Ltd | 25,755 | 18,400 | -7,355 | 5.10 | 2.55 | -2.54 | sell |
| Aberdeen Group plc | 27,919 | 14,913 | -13,006 | 0.01 | 0.01 | -0.01 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 103,890 | 88,290 | -15,600 | 0.38 | 0.28 | -0.10 | sell |
| BNP Paribas Asset Management Holding S.A. | 97,895 | 80,044 | -17,851 | 0.05 | 0.04 | -0.02 | sell |
| Capital Group Private Client Services, Inc. | 182,899 | 159,297 | -23,602 | 0.39 | 0.27 | -0.12 | sell |
| Bellevue Group AG | 58,729 | 34,229 | -24,500 | 0.21 | 0.12 | -0.09 | sell |
| BAILLIE GIFFORD & CO | 3,705,756 | 3,671,195 | -34,561 | 0.62 | 0.52 | -0.10 | sell |
| Capital International, Inc./CA/ | 624,895 | 554,926 | -69,969 | 1.77 | 1.21 | -0.56 | sell |
| Soleus Capital Management, L.P. | 82,750 | 1,150 | -81,600 | 1.54 | 0.02 | -1.53 | sell |
| Capital International Investors | 6,430,884 | 6,113,165 | -317,719 | 0.28 | 0.21 | -0.06 | sell |
| Temasek Holdings (Private) Ltd | 2,388,576 | 1,525,329 | -863,247 | 2.17 | 1.11 | -1.06 | sell |
| BAKER BROS. ADVISORS LP | 10,568,897 | 9,531,880 | -1,037,017 | 24.59 | 18.81 | -5.78 | sell |
| HHLR ADVISORS, LTD. | 5,176,906 | 3,804,406 | -1,372,500 | 25.52 | 24.34 | -1.18 | sell |