| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 10,568,897 | 9,531,880 | -1,037,017 | 24.59 | 18.81 | -5.78 | sell |
| Capital International Investors | 6,430,884 | 6,113,165 | -317,719 | 0.28 | 0.21 | -0.06 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 4,974,289 | 5,098,904 | +124,615 | 0.82 | 0.73 | -0.09 | buy |
| HHLR ADVISORS, LTD. | 5,176,906 | 3,804,406 | -1,372,500 | 25.52 | 24.34 | -1.18 | sell |
| BAILLIE GIFFORD & CO | 3,705,756 | 3,671,195 | -34,561 | 0.62 | 0.52 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,700,088 | 2,937,170 | +237,082 | 0.07 | 0.06 | -0.01 | buy |
| FMR LLC | 1,660,011 | 1,848,063 | +188,052 | 0.02 | 0.02 | -0.00 | buy |
| Temasek Holdings (Private) Ltd | 2,388,576 | 1,525,329 | -863,247 | 2.17 | 1.12 | -1.06 | sell |
| MORGAN STANLEY | 173,032 | 738,140 | +565,108 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 892,349 | 733,983 | -158,366 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 563,314 | 653,721 | +90,407 | 6.33 | 5.34 | -0.99 | buy |
| Paradigm Biocapital Advisors LP | 200,336 | 616,024 | +415,688 | 1.57 | 3.96 | +2.38 | buy |
| Capital International, Inc./CA/ | 624,895 | 554,926 | -69,969 | 1.77 | 1.21 | -0.56 | sell |
| PUBLIC INVESTMENT FUND | 354,385 | 354,385 | 0 | 0.41 | 0.34 | -0.07 | hold |
| CITADEL ADVISORS LLC | 47,034 | 317,113 | +270,079 | 0.01 | 0.05 | +0.04 | buy |
| Baird Financial Group, Inc. | 287,114 | 295,562 | +8,448 | 0.13 | 0.10 | -0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 225,854 | 284,394 | +58,540 | 0.25 | 0.24 | -0.01 | buy |
| Artisan Partners Limited Partnership | 199,838 | 279,648 | +79,810 | 0.07 | 0.08 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 211,815 | 205,580 | -6,235 | 0.00 | 0.00 | -0.00 | sell |
| M&G Plc | 173,075 | 193,163 | +20,088 | 0.14 | 0.22 | +0.08 | buy |
| FIRST TRUST ADVISORS LP | 247,632 | 164,238 | -83,394 | 0.05 | 0.03 | -0.03 | sell |
| Capital Group Private Client Services, Inc. | 182,899 | 159,297 | -23,602 | 0.39 | 0.27 | -0.12 | sell |
| Capital International Sarl | 151,742 | 152,710 | +968 | 0.88 | 0.65 | -0.22 | buy |
| MILLENNIUM MANAGEMENT LLC | 57,125 | 145,763 | +88,638 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 125,412 | 123,595 | -1,817 | 0.02 | 0.02 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 5,280 | 103,063 | +97,783 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 108,129 | 101,529 | -6,600 | 0.03 | 0.02 | -0.01 | sell |
| NORGES BANK | 106,357 | 100,006 | -6,351 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 35,724 | 91,468 | +55,744 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 38,888 | 89,042 | +50,154 | 0.01 | 0.02 | +0.01 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 103,890 | 88,290 | -15,600 | 0.38 | 0.28 | -0.10 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 87,200 | +87,200 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 32,299 | 86,329 | +54,030 | 0.01 | 0.02 | +0.01 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 83,463 | 81,619 | -1,844 | 0.04 | 0.04 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 97,895 | 80,044 | -17,851 | 0.05 | 0.04 | -0.02 | sell |
| CAPITAL INTERNATIONAL LTD /CA/ | 74,548 | 76,048 | +1,500 | 0.72 | 0.57 | -0.15 | buy |
| BARINGS LLC | 67,998 | 71,422 | +3,424 | 0.36 | 0.31 | -0.04 | buy |
| Squarepoint Ops LLC | 72,709 | 69,576 | -3,133 | 0.05 | 0.03 | -0.02 | sell |
| ROYAL BANK OF CANADA | 68,744 | 69,490 | +746 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 56,582 | 62,142 | +5,560 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 57,384 | 59,831 | +2,447 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 9,780 | 55,359 | +45,579 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 52,025 | 51,077 | -948 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 30,658 | 47,404 | +16,746 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,293 | +44,293 | 0.00 | 0.02 | +0.02 | buy |
| AXA S.A. | 53,513 | 42,232 | -11,281 | 0.04 | 0.02 | -0.01 | sell |
| Legal & General Group Plc | 93,689 | 39,144 | -54,545 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 37,764 | 38,252 | +488 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 37,000 | 37,000 | 0 | 0.59 | 0.45 | -0.14 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 26,752 | 34,960 | +8,208 | 0.18 | 0.19 | +0.01 | buy |
| Bellevue Group AG | 58,729 | 34,229 | -24,500 | 0.21 | 0.12 | -0.09 | sell |
| MACQUARIE GROUP LTD | 34,329 | 33,641 | -688 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 45,939 | 31,162 | -14,777 | 0.01 | 0.01 | -0.01 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 30,427 | 30,945 | +518 | 0.08 | 0.07 | -0.01 | buy |
| Greenwoods Asset Management Hong Kong Ltd. | 30,658 | 30,658 | 0 | 0.22 | 0.18 | -0.04 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 11,874 | 27,923 | +16,049 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 667,166 | 25,166 | -642,000 | 0.52 | 0.01 | -0.51 | sell |
| XY Capital Ltd | 30,464 | 24,603 | -5,861 | 3.69 | 5.07 | +1.38 | sell |
| AIA Group Ltd | 21,665 | 24,587 | +2,922 | 0.13 | 0.11 | -0.02 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 26,104 | 24,408 | -1,696 | 0.10 | 0.08 | -0.02 | sell |
| JANE STREET GROUP, LLC | 27,949 | 22,874 | -5,075 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 21,015 | 21,456 | +441 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 16,848 | 21,166 | +4,318 | 0.03 | 0.03 | -0.01 | buy |
| CITIGROUP INC | 26,312 | 20,672 | -5,640 | 0.01 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 43,195 | 20,590 | -22,605 | 0.01 | 0.00 | -0.01 | sell |
| MACKENZIE FINANCIAL CORP | 43,195 | 20,590 | -22,605 | 0.01 | 0.00 | -0.01 | sell |
| Erste Asset Management GmbH | 20,500 | 20,500 | 0 | 0.05 | 0.05 | -0.01 | hold |
| Asset Management One Co., Ltd. | 20,453 | 20,453 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Nan Fung Group Holdings Ltd | 23,022 | 19,997 | -3,025 | 4.45 | 3.16 | -1.29 | sell |
| HRT FINANCIAL LP | 4,434 | 19,244 | +14,810 | 0.00 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 12,374 | 18,870 | +6,496 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 17,158 | 18,541 | +1,383 | 0.01 | 0.01 | -0.00 | buy |
| Long Corridor Asset Management Ltd | 25,755 | 18,400 | -7,355 | 5.10 | 2.55 | -2.54 | sell |
| Capital Group Investment Management Pte. Ltd. | 16,030 | 16,436 | +406 | 0.72 | 0.58 | -0.15 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 6,600 | 16,199 | +9,599 | 0.04 | 0.07 | +0.04 | buy |
| Qube Research & Technologies Ltd | 0 | 15,193 | +15,193 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 27,919 | 14,913 | -13,006 | 0.01 | 0.01 | -0.01 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 11,917 | 14,056 | +2,139 | 0.01 | 0.01 | -0.00 | buy |
| FIL Ltd | 0 | 13,640 | +13,640 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 13,600 | 13,600 | 0 | 0.01 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 12,807 | 12,554 | -253 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 12,297 | 12,302 | +5 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,569 | 12,173 | +3,604 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 3,042 | 11,678 | +8,636 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 0 | 10,900 | +10,900 | 0.00 | 0.95 | +0.95 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,385 | 10,385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Exome Asset Management LLC | 15,300 | 10,000 | -5,300 | 2.32 | 1.39 | -0.93 | sell |
| EFG Asset Management (North America) Corp. | 13,475 | 9,986 | -3,489 | 0.51 | 0.25 | -0.25 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 11,582 | 9,786 | -1,796 | 0.02 | 0.01 | -0.01 | sell |
| Man Group plc | 76,227 | 9,592 | -66,635 | 0.05 | 0.01 | -0.04 | sell |
| Jump Financial, LLC | 0 | 9,426 | +9,426 | 0.00 | 0.04 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 8,510 | 9,403 | +893 | 0.21 | 0.16 | -0.05 | buy |
| JGP Global Gestao de Recursos Ltda. | 9,375 | 9,374 | -1 | 4.12 | 3.94 | -0.18 | sell |
| KBC Group NV | 8,937 | 8,937 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Fiera Capital Corp | 6,011 | 8,442 | +2,431 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 8,229 | 7,901 | -328 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 5,000 | 7,500 | +2,500 | 0.01 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,391 | 6,883 | +5,492 | 0.01 | 0.03 | +0.02 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 6,365 | +6,365 | 0.00 | 1.03 | +1.03 | buy |