| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 117,418 | +117,418 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 417,579 | 515,779 | +98,200 | 0.00 | 0.00 | -0.00 | buy |
| SCOGGIN MANAGEMENT LP | 0 | 84,401 | +84,401 | 0.00 | 0.19 | +0.19 | buy |
| CITADEL ADVISORS LLC | 0 | 60,732 | +60,732 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 101,064 | 150,000 | +48,936 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 40,914 | 54,797 | +13,883 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 11,644 | +11,644 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 10,260 | +10,260 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,674 | 19,008 | +9,334 | 0.01 | 0.01 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,669 | 11,092 | +8,423 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 2,000,000 | 2,007,031 | +7,031 | 0.36 | 0.22 | -0.14 | buy |
| GOLDMAN SACHS GROUP INC | 17,290 | 23,609 | +6,319 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 5,830 | +5,830 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,919 | +3,919 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 4,469,080 | 4,470,000 | +920 | 0.85 | 0.47 | -0.38 | buy |
| SIMPLEX TRADING, LLC | 0 | 635 | +635 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 451 | +451 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 14,571,236 | 14,571,236 | 0 | 1.82 | 1.19 | -0.64 | hold |
| Assenagon Asset Management S.A. | 111,418 | 111,418 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eversept Partners, LP | 124,589 | 124,589 | 0 | 0.06 | 0.03 | -0.03 | hold |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 27,202 | 27,202 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 59,752 | 59,752 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Banque Cantonale Vaudoise | 54,847 | 54,134 | -713 | 0.01 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 1,514 | 310 | -1,204 | 0.00 | 0.00 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 11,552 | 0 | -11,552 | 0.00 | 0.00 | -0.00 | sell |
| NIXON PEABODY TRUST CO | 12,850 | 0 | -12,850 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 1,148,691 | 1,119,703 | -28,988 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 45,000 | 0 | -45,000 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,757,240 | 1,383,854 | -373,386 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,515,585 | 1,095,026 | -420,559 | 0.31 | 0.13 | -0.18 | sell |
| STEMPOINT CAPITAL LP | 434,588 | 0 | -434,588 | 0.59 | 0.00 | -0.59 | sell |