| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 19,522,436 | 19,822,436 | +300,000 | 1.79 | 1.51 | -0.28 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 198,381 | 371,177 | +172,796 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 151,461 | +151,461 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 66,318 | 212,184 | +145,866 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 131,410 | 237,558 | +106,148 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 100,752 | +100,752 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 119,040 | 212,750 | +93,710 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 740,198 | 803,469 | +63,271 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 24,897 | +24,897 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 13,410 | 23,610 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Banque Cantonale Vaudoise | 18,562 | 26,712 | +8,150 | 0.00 | 0.00 | -0.00 | buy |
| State of Tennessee, Department of Treasury | 0 | 5,126 | +5,126 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 995,636 | 997,621 | +1,985 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 5,872 | 7,409 | +1,537 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,077 | 2,454 | +377 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 284 | +284 | 0.00 | 0.00 | 0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 757 | 813 | +56 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 544 | 561 | +17 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,296 | 3,309 | +13 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 64,090 | 64,090 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quinn Opportunity Partners LLC | 10,100 | 10,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SJS Investment Consulting Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Silverberg Bernstein Capital Management LLC | 10,000 | 10,000 | 0 | 0.02 | 0.02 | -0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 6,913 | 6,864 | -49 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,003 | 1,211 | -792 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 20,970 | 19,837 | -1,133 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,727 | 1,439 | -1,288 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,123 | 0 | -3,123 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 25,000 | 20,000 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Compagnie Lombard Odier SCmA | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 11,667 | 0 | -11,667 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 14,046 | 0 | -14,046 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 18,219 | 0 | -18,219 | 0.01 | 0.00 | -0.01 | sell |
| RPO LLC | 18,728 | 0 | -18,728 | 0.07 | 0.00 | -0.07 | sell |
| Handelsbanken Fonder AB | 150,000 | 130,000 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 43,784 | 22,406 | -21,378 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 403,031 | 377,086 | -25,945 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 40,818 | 0 | -40,818 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 952,069 | 739,342 | -212,727 | 0.15 | 0.08 | -0.07 | sell |
| Redmile Group, LLC | 1,034,299 | 0 | -1,034,299 | 0.19 | 0.00 | -0.19 | sell |
| BlackRock, Inc. | 2,212,522 | 1,156,591 | -1,055,931 | 0.00 | 0.00 | -0.00 | sell |