| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 14,571,236 | 18,834,936 | +4,263,700 | 1.19 | 2.11 | +0.92 | buy |
| Redmile Group, LLC | 2,007,031 | 1,807,704 | -199,327 | 0.22 | 0.44 | +0.22 | sell |
| WELLS FARGO & COMPANY/MN | 1,119,703 | 1,122,017 | +2,314 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,095,026 | 952,069 | -142,957 | 0.13 | 0.15 | +0.02 | sell |
| Avidity Partners Management LP | 4,470,000 | 825,000 | -3,645,000 | 0.47 | 0.14 | -0.33 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 515,779 | 652,079 | +136,300 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 111,418 | 439,730 | +328,312 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 150,000 | 150,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 106,363 | +106,363 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 99,343 | +99,343 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 124,589 | 99,313 | -25,276 | 0.03 | 0.03 | +0.00 | sell |
| ALPS ADVISORS INC | 0 | 77,376 | +77,376 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 59,752 | 60,198 | +446 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 54,797 | 54,797 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cubist Systematic Strategies, LLC | 0 | 54,610 | +54,610 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 41,321 | +41,321 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 60,732 | 34,808 | -25,924 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 27,202 | 27,202 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Banque Cantonale Vaudoise | 54,134 | 25,418 | -28,716 | 0.01 | 0.00 | -0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 451 | 19,397 | +18,946 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Capital Wealth Advisors | 0 | 14,000 | +14,000 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 23,609 | 13,329 | -10,280 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 0 | 11,891 | +11,891 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 19,008 | 11,621 | -7,387 | 0.01 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 11,400 | +11,400 | 0.00 | 0.00 | +0.00 | buy |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Silverberg Bernstein Capital Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,919 | 3,851 | -68 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 11,092 | 3,564 | -7,528 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,830 | 3,074 | -2,756 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,953 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 310 | 2,096 | +1,786 | 0.00 | 0.00 | +0.00 | buy |
| Activest Wealth Management | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Qube Research & Technologies Ltd | 48 | 48 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| SCOGGIN MANAGEMENT LP | 84,401 | 0 | -84,401 | 0.19 | 0.00 | -0.19 | sell |
| LAZARD ASSET MANAGEMENT LLC | 10,260 | 0 | -10,260 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 635 | 0 | -635 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 117,418 | 0 | -117,418 | 0.03 | 0.00 | -0.03 | sell |
| XTX Topco Ltd | 11,644 | 0 | -11,644 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MORGAN STANLEY | 1,383,854 | 0 | -1,383,854 | 0.00 | 0.00 | -0.00 | sell |