| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 18,834,936 | 19,522,436 | +687,500 | 2.11 | 2.16 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 99,374 | +99,374 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 106,363 | 166,140 | +59,777 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 46,012 | +46,012 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 27,361 | +27,361 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 16,601 | +16,601 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 11,621 | 19,021 | +7,400 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 11,891 | 17,362 | +5,471 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 19,397 | 24,074 | +4,677 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 54,797 | 58,296 | +3,499 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,953 | 3,577 | +624 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 490 | +490 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 952,069 | 952,069 | 0 | 0.15 | 0.16 | +0.01 | hold |
| Handelsbanken Fonder AB | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eversept Partners, LP | 99,313 | 99,313 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Activest Wealth Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SJS Investment Consulting Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Silverberg Bernstein Capital Management LLC | 10,000 | 10,000 | 0 | 0.04 | 0.03 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,851 | 3,663 | -188 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,074 | 2,885 | -189 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 2,096 | 1,756 | -340 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 13,329 | 12,657 | -672 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 77,376 | 76,630 | -746 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,564 | 2,265 | -1,299 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 60,198 | 57,052 | -3,146 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 652,079 | 646,007 | -6,072 | 0.00 | 0.00 | -0.00 | sell |
| Banque Cantonale Vaudoise | 25,418 | 18,562 | -6,856 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 11,400 | 0 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 34,808 | 21,806 | -13,002 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 1,122,017 | 1,108,038 | -13,979 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Capital Wealth Advisors | 14,000 | 0 | -14,000 | 0.04 | 0.00 | -0.04 | sell |
| NOMURA HOLDINGS INC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 27,202 | 0 | -27,202 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 41,321 | 12,000 | -29,321 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 54,610 | 14,271 | -40,339 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 99,343 | 57,321 | -42,022 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 1,807,704 | 1,694,167 | -113,537 | 0.44 | 0.38 | -0.06 | sell |
| Assenagon Asset Management S.A. | 439,730 | 223,880 | -215,850 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 825,000 | 0 | -825,000 | 0.14 | 0.00 | -0.14 | sell |