| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 7,428,379 | 14,571,236 | +7,142,857 | 0.57 | 1.82 | +1.25 | buy |
| Redmile Group, LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.36 | +0.36 | buy |
| Avidity Partners Management LP | 2,969,800 | 4,469,080 | +1,499,280 | 0.34 | 0.85 | +0.51 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,322,462 | 1,515,585 | +193,123 | 0.15 | 0.31 | +0.16 | buy |
| FMR LLC | 0 | 27,202 | +27,202 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 17,290 | +17,290 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,741,677 | 1,757,240 | +15,563 | 0.00 | 0.00 | +0.00 | buy |
| NIXON PEABODY TRUST CO | 0 | 12,850 | +12,850 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 11,552 | +11,552 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 9,674 | +9,674 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,669 | +2,669 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 1,146,086 | 1,148,691 | +2,605 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 42,974 | 45,000 | +2,026 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,514 | +1,514 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 40,914 | 40,914 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 101,064 | 101,064 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 111,418 | 111,418 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eversept Partners, LP | 124,589 | 124,589 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 59,752 | 59,752 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Qube Research & Technologies Ltd | 186 | 0 | -186 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 553 | 0 | -553 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 5,255 | 0 | -5,255 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 425,179 | 417,579 | -7,600 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 19,638 | 0 | -19,638 | 0.00 | 0.00 | -0.00 | sell |
| Banque Cantonale Vaudoise | 80,701 | 54,847 | -25,854 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 71,487 | 0 | -71,487 | 0.00 | 0.00 | -0.00 | sell |