| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORTHERN TRUST CORP | 0 | 403,031 | +403,031 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 46,012 | 198,381 | +152,369 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 646,007 | 740,198 | +94,191 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 57,052 | 131,410 | +74,358 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 43,784 | +43,784 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| RPO LLC | 0 | 18,728 | +18,728 | 0.00 | 0.07 | +0.07 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 14,046 | +14,046 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 13,410 | +13,410 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,296 | 64,090 | +5,794 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 490 | 5,872 | +5,382 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,885 | 6,913 | +4,028 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 19,021 | 20,970 | +1,949 | 0.01 | 0.01 | -0.00 | buy |
| State of Wyoming | 16,601 | 18,219 | +1,618 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 1,756 | 2,727 | +971 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 757 | +757 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 19,522,436 | 19,522,436 | 0 | 2.16 | 1.79 | -0.37 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 952,069 | 952,069 | 0 | 0.16 | 0.15 | -0.01 | hold |
| Handelsbanken Fonder AB | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SJS Investment Consulting Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Strengthening Families & Communities, LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Silverberg Bernstein Capital Management LLC | 10,000 | 10,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| DEUTSCHE BANK AG\ | 253,375 | 253,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 2,265 | 2,003 | -262 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,577 | 3,296 | -281 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,663 | 3,123 | -540 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 14,271 | 11,667 | -2,604 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 12,000 | 0 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 12,657 | 0 | -12,657 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 57,321 | 40,818 | -16,503 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 17,362 | 0 | -17,362 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 21,806 | 0 | -21,806 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 24,074 | 0 | -24,074 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 27,361 | 0 | -27,361 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 99,374 | 66,318 | -33,056 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 166,140 | 119,040 | -47,100 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 76,630 | 0 | -76,630 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 99,313 | 0 | -99,313 | 0.03 | 0.00 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 1,108,038 | 995,636 | -112,402 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 223,880 | 0 | -223,880 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 2,674,311 | 2,212,522 | -461,789 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 1,694,167 | 1,034,299 | -659,868 | 0.38 | 0.19 | -0.18 | sell |