| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 2,250,000 | 4,210,784 | +1,960,784 | 2.40 | 3.33 | +0.93 | buy |
| Casdin Capital, LLC | 1,450,000 | 1,875,000 | +425,000 | 4.34 | 3.83 | -0.51 | buy |
| Opaleye Management Inc. | 99,000 | 255,000 | +156,000 | 0.80 | 1.53 | +0.73 | buy |
| Vestmark Advisory Solutions, Inc. | 265,981 | 420,397 | +154,416 | 0.41 | 0.50 | +0.09 | buy |
| TWO SIGMA INVESTMENTS, LP | 507,887 | 614,568 | +106,681 | 0.04 | 0.04 | 0.00 | buy |
| Chevy Chase Trust Holdings, LLC | 991,175 | 1,074,610 | +83,435 | 0.11 | 0.10 | -0.01 | buy |
| PDT Partners, LLC | 160,997 | 222,971 | +61,974 | 0.54 | 0.58 | +0.04 | buy |
| MPM BioImpact LLC | 382,598 | 432,598 | +50,000 | 2.73 | 1.91 | -0.82 | buy |
| NEOS Investment Management LLC | 30,713 | 74,670 | +43,957 | 0.09 | 0.13 | +0.04 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 19,384 | 51,250 | +31,866 | 0.11 | 0.18 | +0.07 | buy |
| Krilogy Financial LLC | 22,504 | 50,117 | +27,613 | 0.06 | 0.11 | +0.05 | buy |
| McGuire Investment Group, LLC | 50,509 | 76,492 | +25,983 | 0.26 | 0.31 | +0.05 | buy |
| Rockefeller Capital Management L.P. | 56,479 | 76,345 | +19,866 | 0.01 | 0.01 | 0.00 | buy |
| CAPITAL ADVISORS INC/OK | 284,738 | 300,653 | +15,915 | 0.19 | 0.18 | -0.02 | buy |
| ExodusPoint Capital Management, LP | 67,252 | 80,752 | +13,500 | 0.03 | 0.03 | 0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 102,233 | 90,058 | +12,175 | 0.00 | 0.00 | 0.00 | sell |
| Hudson Bay Capital Management LP | 237,500 | 247,300 | +9,800 | 0.05 | 0.04 | -0.01 | buy |
| Scientech Research LLC | 10,441 | 20,217 | +9,776 | 0.32 | 0.29 | -0.02 | buy |
| JENNISON ASSOCIATES LLC | 23,848 | 33,616 | +9,768 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,355 | 18,474 | +8,119 | 0.06 | 0.06 | +0.00 | buy |
| Lewis Asset Management, LLC | 23,103 | 30,593 | +7,490 | 0.65 | 0.69 | +0.05 | buy |
| Curi Capital, LLC | 28,060 | 34,525 | +6,465 | 0.03 | 0.02 | -0.00 | buy |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 21,000 | 27,000 | +6,000 | 0.53 | 0.51 | -0.02 | buy |
| Capital Impact Advisors, LLC | 26,128 | 31,993 | +5,865 | 1.05 | 1.14 | +0.10 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,695 | 17,449 | +5,754 | 0.00 | 0.00 | 0.00 | buy |
| ALPS ADVISORS INC | 62,295 | 67,782 | +5,487 | 0.01 | 0.01 | -0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 34,450 | 37,550 | +3,100 | 0.03 | 0.02 | -0.00 | buy |
| PROFUND ADVISORS LLC | 50,976 | 48,300 | +2,676 | 0.07 | 0.05 | 0.00 | sell |
| LMR Partners LLP | 27,490 | 29,958 | +2,468 | 0.02 | 0.02 | +0.00 | buy |
| ProShare Advisors LLC | 20,769 | 23,235 | +2,466 | 0.00 | 0.00 | 0.00 | buy |
| Orchard Capital Management, LLC | 170,006 | 172,316 | +2,310 | 1.62 | 1.39 | -0.23 | buy |
| GUGGENHEIM CAPITAL LLC | 61,194 | 63,495 | +2,301 | 0.01 | 0.01 | 0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 22,801 | 20,521 | +2,280 | 0.03 | 0.02 | 0.00 | sell |
| ALGERT GLOBAL LLC | 14,700 | 16,800 | +2,100 | 0.02 | 0.02 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 88,502 | 86,925 | +1,577 | 0.00 | 0.00 | -0.00 | sell |
| C M BIDWELL & ASSOCIATES LTD | 12 | 1,427 | +1,415 | 0.00 | 0.03 | +0.03 | buy |
| Intellectus Partners, LLC | 55,650 | 57,000 | +1,350 | 0.49 | 0.41 | -0.08 | buy |
| Vident Advisory, LLC | 16,465 | 17,488 | +1,023 | 0.01 | 0.01 | 0.00 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 15,592 | 16,602 | +1,010 | 0.01 | 0.01 | -0.00 | buy |
| FIL Ltd | 8,943 | 9,624 | +681 | 0.00 | 0.00 | -0.00 | buy |
| Interchange Capital Partners, LLC | 10,239 | 10,909 | +670 | 0.23 | 0.20 | -0.03 | buy |
| AlphaQuest LLC | 10,416 | 9,807 | +609 | 0.07 | 0.05 | 0.00 | sell |
| CIBC WORLD MARKET INC. | 19,878 | 20,237 | +359 | 0.00 | 0.00 | -0.00 | buy |
| AZZAD ASSET MANAGEMENT INC /ADV | 8,323 | 8,496 | +173 | 0.03 | 0.03 | -0.00 | buy |
| Resonant Capital Advisors, LLC | 41,348 | 41,454 | +106 | 0.12 | 0.10 | -0.02 | buy |
| BENJAMIN EDWARDS INC | 527 | 562 | +35 | 0.00 | 0.00 | -0.00 | buy |
| CI INVESTMENTS INC. | 3,835 | 3,838 | +3 | 0.00 | 0.00 | 0.00 | buy |
| Elmwood Wealth Management, Inc. | 67,909 | 67,899 | -10 | 1.45 | 0.80 | -0.65 | sell |
| Cyndeo Wealth Partners, LLC | 8,236 | 8,224 | -12 | 0.02 | 0.02 | -0.00 | sell |
| Stone House Investment Management, LLC | 152 | 74 | -78 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,906 | 2,719 | -187 | 0.06 | 0.04 | -0.02 | sell |
| NATIXIS | 2,234 | 2,045 | -189 | 0.00 | 0.00 | -0.00 | sell |
| Fort Sheridan Advisors LLC | 7,677 | 7,478 | -199 | 0.05 | 0.04 | -0.01 | sell |
| Evolutionary Tree Capital Management, LLC | 37,036 | 36,770 | -266 | 1.25 | 1.02 | -0.23 | sell |
| SECTORAL ASSET MANAGEMENT INC | 9,300 | 8,800 | -500 | 0.12 | 0.10 | -0.03 | sell |
| KRAEMATON INVESTMENT ADVISORS, INC | 10,690 | 9,815 | -875 | 0.36 | 0.27 | -0.09 | sell |
| Corton Capital Inc. | 10,186 | 8,722 | -1,464 | 0.10 | 0.09 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 50,000 | 48,000 | -2,000 | 0.15 | 0.13 | -0.03 | sell |
| E Fund Management Co., Ltd. | 16,551 | 14,460 | -2,091 | 0.03 | 0.02 | -0.01 | sell |
| Green Alpha Advisors, LLC | 10,103 | 7,964 | -2,139 | 0.22 | 0.16 | -0.06 | sell |
| Relyea Zuckerberg Hanson LLC | 13,218 | 10,976 | -2,242 | 0.08 | 0.05 | -0.03 | sell |
| Quadcap Wealth Management, LLC | 10,458 | 7,916 | -2,542 | 0.08 | 0.05 | -0.03 | sell |
| Rafferty Asset Management, LLC | 328,998 | 323,561 | -5,437 | 0.04 | 0.03 | -0.01 | sell |
| Granahan Investment Management, LLC | 257,791 | 220,219 | -37,572 | 0.26 | 0.21 | -0.05 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 298,000 | 238,000 | -60,000 | 0.03 | 0.02 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,478,562 | 3,399,318 | -79,244 | 1.02 | 0.93 | -0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,834,143 | 1,625,051 | -209,092 | 0.01 | 0.01 | -0.00 | sell |
| ARK Investment Management LLC | 11,412,449 | 10,989,282 | -423,167 | 2.06 | 2.09 | +0.03 | sell |