| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 11,412,449 | 10,989,282 | -423,167 | 2.06 | 2.09 | +0.03 | sell |
| VANGUARD GROUP INC | 8,347,449 | 9,093,712 | +746,263 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 4,735,861 | 4,597,822 | -138,039 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 2,250,000 | 4,210,784 | +1,960,784 | 2.40 | 3.33 | +0.93 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,456,917 | 4,162,129 | +1,705,212 | 0.01 | 0.02 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 3,478,562 | 3,399,318 | -79,244 | 0.08 | 0.06 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,478,562 | 3,399,318 | -79,244 | 1.02 | 0.93 | -0.09 | sell |
| MORGAN STANLEY | 2,545,022 | 2,644,851 | +99,829 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 1,186,603 | 2,206,342 | +1,019,739 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,973,269 | 2,044,257 | +70,988 | 0.01 | 0.01 | -0.00 | buy |
| FEDERATED HERMES, INC. | 2,016,300 | 1,929,700 | -86,600 | 0.15 | 0.12 | -0.03 | sell |
| Casdin Capital, LLC | 1,450,000 | 1,875,000 | +425,000 | 4.36 | 3.84 | -0.52 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,834,143 | 1,625,051 | -209,092 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,663,742 | 1,571,524 | -92,218 | 0.02 | 0.02 | -0.00 | sell |
| Rokos Capital Management LLP | 1,463,630 | 1,463,630 | 0 | 1.36 | 1.03 | -0.33 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,170,829 | 1,225,696 | +54,867 | 0.01 | 0.01 | -0.00 | buy |
| Chevy Chase Trust Holdings, LLC | 991,175 | 1,074,610 | +83,435 | 0.11 | 0.10 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 824,527 | 1,067,460 | +242,933 | 0.01 | 0.01 | +0.00 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 1,030,621 | 1,030,621 | 0 | 2.85 | 2.13 | -0.73 | hold |
| CITADEL ADVISORS LLC | 1,259,292 | 890,784 | -368,508 | 0.04 | 0.02 | -0.02 | sell |
| NORTHERN TRUST CORP | 886,388 | 871,295 | -15,093 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 883,470 | 805,103 | -78,367 | 0.03 | 0.02 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 33,256 | 795,514 | +762,258 | 0.00 | 0.08 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 700,228 | 728,295 | +28,067 | 0.01 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 464,017 | 659,317 | +195,300 | 0.03 | 0.04 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 379,785 | 626,423 | +246,638 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 507,887 | 614,568 | +106,681 | 0.04 | 0.04 | +0.00 | buy |
| NORGES BANK | 536,172 | 614,151 | +77,979 | 0.00 | 0.00 | -0.00 | buy |
| Discovery Value Fund | 561,561 | 561,561 | 0 | 7.82 | 5.35 | -2.46 | hold |
| JPMORGAN CHASE & CO | 636,117 | 543,107 | -93,010 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 382,598 | 432,598 | +50,000 | 2.73 | 1.91 | -0.82 | buy |
| Vestmark Advisory Solutions, Inc. | 265,981 | 420,397 | +154,416 | 0.41 | 0.50 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 432,012 | 379,638 | -52,374 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 393,595 | 362,005 | -31,590 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 167,606 | 342,966 | +175,360 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 890,498 | 335,408 | -555,090 | 0.05 | 0.02 | -0.04 | sell |
| UBS Group AG | 274,524 | 331,586 | +57,062 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 328,998 | 323,561 | -5,437 | 0.04 | 0.03 | -0.01 | sell |
| CAPITAL ADVISORS INC/OK | 284,738 | 300,653 | +15,915 | 0.19 | 0.18 | -0.02 | buy |
| Temasek Holdings (Private) Ltd | 279,693 | 279,693 | 0 | 0.05 | 0.04 | -0.01 | hold |
| AMERICAN CENTURY COMPANIES INC | 248,529 | 266,964 | +18,435 | 0.01 | 0.00 | -0.00 | buy |
| PINNACLE ASSOCIATES LTD | 0 | 255,716 | +255,716 | 0.00 | 0.11 | +0.11 | buy |
| Opaleye Management Inc. | 99,000 | 255,000 | +156,000 | 0.80 | 1.53 | +0.73 | buy |
| Hudson Bay Capital Management LP | 237,500 | 247,300 | +9,800 | 0.06 | 0.06 | -0.00 | buy |
| Squarepoint Ops LLC | 10,037 | 245,776 | +235,739 | 0.00 | 0.03 | +0.03 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 298,000 | 238,000 | -60,000 | 0.03 | 0.02 | -0.01 | sell |
| PDT Partners, LLC | 160,997 | 222,971 | +61,974 | 0.54 | 0.58 | +0.04 | buy |
| Granahan Investment Management, LLC | 257,791 | 220,219 | -37,572 | 0.26 | 0.21 | -0.05 | sell |
| Mirae Asset Global Investments Co., Ltd. | 185,858 | 217,394 | +31,536 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 202,594 | 215,758 | +13,164 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 228,793 | 214,076 | -14,717 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 203,684 | 203,684 | 0 | 0.33 | 0.24 | -0.10 | hold |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.56 | 0.57 | +0.01 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 188,501 | +188,501 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 351,330 | 185,295 | -166,035 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 178,879 | +178,879 | 0.00 | 0.00 | +0.00 | buy |
| Orchard Capital Management, LLC | 170,006 | 172,316 | +2,310 | 1.62 | 1.39 | -0.23 | buy |
| Swiss National Bank | 165,700 | 167,900 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 163,358 | 166,538 | +3,180 | 0.01 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 154,269 | 154,269 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Neuberger Berman Group LLC | 135,637 | 133,787 | -1,850 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 126,624 | 126,624 | 0 | 0.00 | 0.00 | -0.00 | hold |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 117,315 | 117,315 | 0 | 0.45 | 0.94 | +0.49 | hold |
| ROYAL BANK OF CANADA | 153,612 | 115,100 | -38,512 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 111,204 | 110,243 | -961 | 0.01 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 81,382 | 100,799 | +19,417 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 195,499 | 99,524 | -95,975 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 72,644 | 96,695 | +24,051 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 204,285 | 93,832 | -110,453 | 0.01 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 92,578 | +92,578 | 0.00 | 0.03 | +0.03 | buy |
| LAZARD ASSET MANAGEMENT LLC | 102,233 | 90,058 | -12,175 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 87,426 | +87,426 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 88,502 | 86,925 | -1,577 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 80,743 | 86,557 | +5,814 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,400 | 85,531 | -3,869 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 68,523 | 84,092 | +15,569 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 94,720 | 81,041 | -13,679 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 67,252 | 80,752 | +13,500 | 0.03 | 0.03 | +0.00 | buy |
| McGuire Investment Group, LLC | 50,509 | 76,492 | +25,983 | 0.26 | 0.31 | +0.05 | buy |
| Rockefeller Capital Management L.P. | 56,479 | 76,345 | +19,866 | 0.01 | 0.01 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 78,129 | 75,000 | -3,129 | 0.01 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 30,713 | 74,670 | +43,957 | 0.09 | 0.13 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 210,161 | 74,515 | -135,646 | 0.01 | 0.00 | -0.01 | sell |
| Elmwood Wealth Management, Inc. | 67,909 | 67,899 | -10 | 1.45 | 0.80 | -0.65 | sell |
| ALPS ADVISORS INC | 62,295 | 67,782 | +5,487 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,231 | 66,166 | +2,935 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 11,751 | 64,673 | +52,922 | 0.01 | 0.05 | +0.04 | buy |
| GUGGENHEIM CAPITAL LLC | 61,194 | 63,495 | +2,301 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,929 | 58,502 | -7,427 | 0.01 | 0.00 | -0.00 | sell |
| Amundi | 56,508 | 57,328 | +820 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 55,650 | 57,000 | +1,350 | 0.49 | 0.41 | -0.08 | buy |
| Jump Financial, LLC | 0 | 52,560 | +52,560 | 0.00 | 0.04 | +0.04 | buy |
| LPL Financial LLC | 46,536 | 51,591 | +5,055 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 51,438 | +51,438 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 49,256 | 51,292 | +2,036 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 19,384 | 51,250 | +31,866 | 0.11 | 0.18 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 54,492 | 51,225 | -3,267 | 0.00 | 0.00 | -0.00 | sell |
| Krilogy Financial LLC | 22,504 | 50,117 | +27,613 | 0.06 | 0.11 | +0.05 | buy |
| Cetera Investment Advisers | 0 | 48,953 | +48,953 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 50,976 | 48,300 | -2,676 | 0.07 | 0.05 | -0.02 | sell |