| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 14,207,324 | 14,509,247 | +301,923 | 0.85 | 1.45 | +0.60 | buy |
| BlackRock, Inc. | 10,276,849 | 12,155,806 | +1,878,957 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 6,418,836 | 6,922,676 | +503,840 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 5,331,064 | 5,728,177 | +397,113 | 0.04 | 0.06 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,698,738 | 4,705,901 | +2,007,163 | 0.04 | 0.05 | +0.01 | buy |
| REGENERON PHARMACEUTICALS, INC. | 3,702,995 | 3,702,995 | 0 | 98.49 | 99.14 | +0.65 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,696,187 | 2,851,472 | +155,285 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 859,552 | 2,689,486 | +1,829,934 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,931,849 | 2,318,110 | +386,261 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 2,327,852 | 2,081,397 | -246,455 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,759,898 | 2,067,222 | +307,324 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 2,192,461 | 1,973,061 | -219,400 | 0.01 | 0.02 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 2,192,461 | 1,973,061 | -219,400 | 0.23 | 0.36 | +0.13 | sell |
| Contrarius Group Holdings Ltd | 714,480 | 1,911,839 | +1,197,359 | 0.31 | 1.39 | +1.08 | buy |
| JUPITER ASSET MANAGEMENT LTD | 1,037,918 | 1,781,063 | +743,145 | 0.07 | 0.12 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 1,455,619 | 1,628,241 | +172,622 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,737,450 | 1,611,534 | -125,916 | 0.05 | 0.08 | +0.03 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 1,397,243 | +1,397,243 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,242,378 | 1,381,703 | +139,325 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 931,391 | 1,012,706 | +81,315 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 872,579 | 966,293 | +93,714 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 945,756 | 941,285 | -4,471 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 259,709 | 748,636 | +488,927 | 0.01 | 0.02 | +0.02 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 193,026 | 730,122 | +537,096 | 0.02 | 0.08 | +0.07 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 731,421 | 724,286 | -7,135 | 0.45 | 0.71 | +0.25 | sell |
| AQR CAPITAL MANAGEMENT LLC | 313,695 | 630,529 | +316,834 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 623,601 | 623,600 | -1 | 0.06 | 0.08 | +0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 591,277 | 579,430 | -11,847 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 401,661 | 576,930 | +175,269 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 443,927 | 550,144 | +106,217 | 0.05 | 0.08 | +0.02 | buy |
| JPMORGAN CHASE & CO | 743,698 | 548,491 | -195,207 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 608,665 | 521,465 | -87,200 | 0.01 | 0.01 | +0.00 | sell |
| HRT FINANCIAL LP | 764,890 | 502,337 | -262,553 | 0.02 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 39,378 | 465,499 | +426,121 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 950,250 | 458,241 | -492,009 | 0.01 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 315,400 | 445,400 | +130,000 | 1.66 | 3.25 | +1.59 | buy |
| Invesco Ltd. | 433,290 | 434,753 | +1,463 | 0.00 | 0.00 | +0.00 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 578,562 | 429,540 | -149,022 | 0.32 | 0.42 | +0.10 | sell |
| JANE STREET GROUP, LLC | 332,471 | 384,957 | +52,486 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 354,947 | 368,617 | +13,670 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 0 | 355,000 | +355,000 | 0.00 | 0.34 | +0.34 | buy |
| ARMISTICE CAPITAL, LLC | 1,156,000 | 336,000 | -820,000 | 0.25 | 0.14 | -0.11 | sell |
| WELLS FARGO & COMPANY/MN | 433,742 | 333,897 | -99,845 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 314,202 | 328,000 | +13,798 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 239,247 | 283,958 | +44,711 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 270,011 | +270,011 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 313,685 | 261,864 | -51,821 | 0.02 | 0.02 | +0.01 | sell |
| Opaleye Management Inc. | 0 | 245,000 | +245,000 | 0.00 | 0.41 | +0.41 | buy |
| Nuveen, LLC | 232,732 | 240,817 | +8,085 | 0.00 | 0.00 | +0.00 | buy |
| Canal Insurance CO | 100,000 | 230,000 | +130,000 | 0.22 | 0.63 | +0.42 | buy |
| Swiss National Bank | 201,000 | 217,800 | +16,800 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 142,735 | 209,983 | +67,248 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 191,350 | 208,301 | +16,951 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 200,998 | 200,998 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rafferty Asset Management, LLC | 215,428 | 199,758 | -15,670 | 0.01 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 98,597 | 186,781 | +88,184 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 233,080 | 178,301 | -54,779 | 0.18 | 0.14 | -0.04 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 169,286 | +169,286 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 86,573 | 167,807 | +81,234 | 0.04 | 0.05 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 153,497 | 164,186 | +10,689 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 166,721 | 159,803 | -6,918 | 0.05 | 0.07 | +0.02 | sell |
| BARCLAYS PLC | 511,240 | 147,242 | -363,998 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 149,231 | 145,512 | -3,719 | 0.02 | 0.02 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121,988 | 142,798 | +20,810 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 140,218 | 141,523 | +1,305 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 141,081 | +141,081 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 99,006 | 138,259 | +39,253 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 137,425 | +137,425 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 132,465 | 136,588 | +4,123 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 124,493 | 133,974 | +9,481 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 73,526 | 128,209 | +54,683 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 120,297 | 122,861 | +2,564 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 83,051 | 120,356 | +37,305 | 0.01 | 0.02 | +0.01 | buy |
| PDT Partners, LLC | 121,541 | 116,641 | -4,900 | 0.07 | 0.09 | +0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 132,647 | 113,904 | -18,743 | 0.02 | 0.02 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 74,028 | 109,290 | +35,262 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 105,165 | 106,924 | +1,759 | 0.01 | 0.02 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 103,100 | 103,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Elmwood Wealth Management, Inc. | 77,924 | 102,924 | +25,000 | 0.22 | 0.36 | +0.14 | buy |
| Aquatic Capital Management LLC | 73,849 | 95,196 | +21,347 | 0.02 | 0.04 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 93,811 | 94,186 | +375 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 96,936 | 93,645 | -3,291 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 98,764 | 93,620 | -5,144 | 0.00 | 0.00 | +0.00 | sell |
| D.A. DAVIDSON & CO. | 84,000 | 93,260 | +9,260 | 0.00 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 90,685 | 90,049 | -636 | 0.02 | 0.04 | +0.01 | sell |
| SG Americas Securities, LLC | 73,143 | 89,688 | +16,545 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 189,076 | 89,223 | -99,853 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 79,664 | 89,055 | +9,391 | 0.02 | 0.04 | +0.02 | buy |
| BENJAMIN EDWARDS INC | 79,200 | 82,563 | +3,363 | 0.01 | 0.01 | +0.00 | buy |
| Orchard Capital Management, LLC | 82,030 | 82,030 | 0 | 0.64 | 1.38 | +0.74 | hold |
| Quadrature Capital Ltd | 216,041 | 75,032 | -141,009 | 0.02 | 0.01 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avidity Partners Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.19 | +0.19 | buy |
| Brevan Howard Capital Management LP | 15,202 | 73,923 | +58,721 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 73,340 | +73,340 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 126,426 | 70,559 | -55,867 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 63,178 | 69,324 | +6,146 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 64,000 | 64,000 | 0 | 0.02 | 0.02 | +0.01 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 75,167 | 62,509 | -12,658 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 315,000 | 60,000 | -255,000 | 0.02 | 0.00 | -0.01 | sell |