| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 10,989,282 | 11,595,789 | +606,507 | 2.09 | 2.30 | +0.21 | buy |
| VANGUARD GROUP INC | 9,093,712 | 9,100,068 | +6,356 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 4,210,784 | 4,800,000 | +589,216 | 3.33 | 3.21 | -0.12 | buy |
| STATE STREET CORP | 4,597,822 | 4,362,780 | -235,042 | 0.01 | 0.00 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 3,399,318 | 3,257,689 | -141,629 | 0.06 | 0.05 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 3,399,318 | 3,257,689 | -141,629 | 0.93 | 0.84 | -0.09 | sell |
| MORGAN STANLEY | 2,644,851 | 2,337,709 | -307,142 | 0.01 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,929,700 | 2,300,889 | +371,189 | 0.12 | 0.12 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,044,257 | 2,293,943 | +249,686 | 0.01 | 0.00 | -0.00 | buy |
| FMR LLC | 2,206,342 | 2,228,418 | +22,076 | 0.00 | 0.00 | -0.00 | buy |
| Casdin Capital, LLC | 1,875,000 | 2,000,000 | +125,000 | 3.84 | 3.42 | -0.42 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,571,524 | 1,782,884 | +211,360 | 0.02 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,225,696 | 1,324,561 | +98,865 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,067,460 | 1,266,602 | +199,142 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,625,051 | 1,244,959 | -380,092 | 0.01 | 0.00 | -0.00 | sell |
| Rokos Capital Management LLP | 1,463,630 | 1,140,973 | -322,657 | 1.03 | 0.59 | -0.44 | sell |
| Chevy Chase Trust Holdings, LLC | 1,074,610 | 1,042,625 | -31,985 | 0.10 | 0.07 | -0.02 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 1,030,621 | 1,029,982 | -639 | 2.13 | 1.63 | -0.49 | sell |
| NORTHERN TRUST CORP | 871,295 | 835,351 | -35,944 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 614,568 | 829,285 | +214,717 | 0.04 | 0.04 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 728,295 | 789,831 | +61,536 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,162,129 | 781,774 | -3,380,355 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA ADVISERS, LP | 659,317 | 769,917 | +110,600 | 0.04 | 0.04 | -0.00 | buy |
| CITADEL ADVISORS LLC | 890,784 | 762,680 | -128,104 | 0.02 | 0.02 | -0.01 | sell |
| Pictet Asset Management Holding SA | 805,103 | 744,032 | -61,071 | 0.02 | 0.02 | -0.01 | sell |
| JPMORGAN CHASE & CO | 543,107 | 669,105 | +125,998 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 626,423 | 647,734 | +21,311 | 0.00 | 0.00 | -0.00 | buy |
| Discovery Value Fund | 561,561 | 561,561 | 0 | 5.35 | 6.39 | +1.04 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 379,638 | 512,309 | +132,671 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 795,514 | 452,448 | -343,066 | 0.08 | 0.04 | -0.04 | sell |
| MPM BioImpact LLC | 432,598 | 443,503 | +10,905 | 1.91 | 1.54 | -0.37 | buy |
| Bank of New York Mellon Corp | 362,005 | 364,306 | +2,301 | 0.00 | 0.00 | -0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 420,397 | 355,325 | -65,072 | 0.50 | 0.33 | -0.17 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 188,501 | 347,483 | +158,982 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 266,964 | 330,514 | +63,550 | 0.00 | 0.00 | -0.00 | buy |
| CAPITAL ADVISORS INC/OK | 300,653 | 311,045 | +10,392 | 0.18 | 0.14 | -0.03 | buy |
| Temasek Holdings (Private) Ltd | 279,693 | 279,693 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Hudson Bay Capital Management LP | 247,300 | 275,000 | +27,700 | 0.06 | 0.05 | -0.01 | buy |
| UBS Group AG | 331,586 | 255,551 | -76,035 | 0.00 | 0.00 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 255,716 | 251,078 | -4,638 | 0.11 | 0.09 | -0.02 | sell |
| JANE STREET GROUP, LLC | 93,832 | 245,426 | +151,594 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 154,269 | 243,044 | +88,775 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 614,151 | 240,415 | -373,736 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 222,971 | 227,220 | +4,249 | 0.58 | 0.48 | -0.10 | buy |
| Rafferty Asset Management, LLC | 323,561 | 225,212 | -98,349 | 0.03 | 0.02 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,524 | 220,638 | +121,114 | 0.00 | 0.01 | +0.00 | buy |
| Opaleye Management Inc. | 255,000 | 218,000 | -37,000 | 1.53 | 1.11 | -0.41 | sell |
| Granahan Investment Management, LLC | 220,219 | 214,910 | -5,309 | 0.21 | 0.19 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 214,076 | 212,457 | -1,619 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 185,295 | 203,373 | +18,078 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 215,758 | 201,657 | -14,101 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 25,721 | 186,440 | +160,719 | 0.01 | 0.03 | +0.03 | buy |
| Swiss National Bank | 167,900 | 180,300 | +12,400 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 166,538 | 175,335 | +8,797 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 133,787 | 171,362 | +37,575 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 170,828 | +170,828 | 0.00 | 0.06 | +0.06 | buy |
| Orchard Capital Management, LLC | 172,316 | 170,006 | -2,310 | 1.39 | 1.15 | -0.24 | sell |
| Avidity Partners Management LP | 0 | 170,000 | +170,000 | 0.00 | 0.16 | +0.16 | buy |
| Russell Investments Group, Ltd. | 110,243 | 150,578 | +40,335 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 74,670 | 149,630 | +74,960 | 0.13 | 0.14 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 139,419 | +139,419 | 0.00 | 0.51 | +0.51 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 238,000 | 138,468 | -99,532 | 0.02 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 74,515 | 131,011 | +56,496 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 126,624 | 127,435 | +811 | 0.00 | 0.00 | -0.00 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 117,315 | 117,315 | 0 | 0.94 | 1.44 | +0.50 | hold |
| LAZARD ASSET MANAGEMENT LLC | 90,058 | 116,390 | +26,332 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 115,100 | 114,716 | -384 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 342,966 | 108,382 | -234,584 | 0.01 | 0.00 | -0.01 | sell |
| Rockefeller Capital Management L.P. | 76,345 | 100,914 | +24,569 | 0.01 | 0.01 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 99,952 | +99,952 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 96,695 | 96,030 | -665 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 84,092 | 91,508 | +7,416 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,531 | 89,851 | +4,320 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 86,557 | 87,558 | +1,001 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 86,925 | 86,484 | -441 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 100,799 | 85,826 | -14,973 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 178,879 | 75,674 | -103,205 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 67,782 | 75,237 | +7,455 | 0.01 | 0.01 | -0.00 | buy |
| DekaBank Deutsche Girozentrale | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| McGuire Investment Group, LLC | 76,492 | 71,994 | -4,498 | 0.31 | 0.23 | -0.08 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 70,355 | +70,355 | 0.00 | 0.11 | +0.11 | buy |
| ALGERT GLOBAL LLC | 16,800 | 68,372 | +51,572 | 0.02 | 0.05 | +0.03 | buy |
| Elmwood Wealth Management, Inc. | 67,899 | 67,174 | -725 | 0.80 | 0.67 | -0.13 | sell |
| TUDOR INVESTMENT CORP ET AL | 47,475 | 61,783 | +14,308 | 0.02 | 0.02 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 61,528 | +61,528 | 0.00 | 0.03 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 63,495 | 61,266 | -2,229 | 0.01 | 0.01 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 60,298 | +60,298 | 0.00 | 0.03 | +0.03 | buy |
| SIT INVESTMENT ASSOCIATES INC | 37,550 | 59,900 | +22,350 | 0.02 | 0.03 | +0.01 | buy |
| Intellectus Partners, LLC | 57,000 | 58,225 | +1,225 | 0.41 | 0.36 | -0.06 | buy |
| LPL Financial LLC | 51,591 | 57,326 | +5,735 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,502 | 56,181 | -2,321 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 46,496 | 55,696 | +9,200 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 51,292 | 55,556 | +4,264 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 5,508 | 55,155 | +49,647 | 0.00 | 0.01 | +0.01 | buy |
| Krilogy Financial LLC | 50,117 | 54,673 | +4,556 | 0.11 | 0.09 | -0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 66,166 | 54,192 | -11,974 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 29,958 | 52,567 | +22,609 | 0.02 | 0.03 | +0.00 | buy |
| XTX Topco Ltd | 18,263 | 50,464 | +32,201 | 0.07 | 0.10 | +0.03 | buy |
| Scientech Research LLC | 20,217 | 47,101 | +26,884 | 0.29 | 0.22 | -0.08 | buy |
| Lewis Asset Management, LLC | 30,593 | 46,533 | +15,940 | 0.69 | 0.80 | +0.10 | buy |