| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 14,509,247 | 16,875,684 | +2,366,437 | 1.45 | 1.85 | +0.41 | buy |
| BlackRock, Inc. | 12,155,806 | 15,409,023 | +3,253,217 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 6,922,676 | 9,234,987 | +2,312,311 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 5,728,177 | 6,443,323 | +715,146 | 0.06 | 0.07 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,705,901 | 5,235,348 | +529,447 | 0.05 | 0.07 | +0.02 | buy |
| FMR LLC | 2,067,222 | 4,773,034 | +2,705,812 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,526,926 | +4,526,926 | 0.00 | 0.67 | +0.67 | buy |
| REGENERON PHARMACEUTICALS, INC. | 3,702,995 | 3,702,995 | 0 | 99.14 | 35.35 | -63.79 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,851,472 | 3,631,061 | +779,589 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,397,243 | 3,280,760 | +1,883,517 | 0.01 | 0.02 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,973,061 | 2,897,529 | +924,468 | 0.02 | 0.03 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 1,973,061 | 2,897,529 | +924,468 | 0.36 | 0.63 | +0.28 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,318,110 | 2,602,944 | +284,834 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,628,241 | 2,264,471 | +636,230 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 2,689,486 | 2,152,912 | -536,574 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,611,534 | 2,066,356 | +454,822 | 0.08 | 0.15 | +0.07 | buy |
| Contrarius Group Holdings Ltd | 1,911,839 | 1,955,228 | +43,389 | 1.39 | 1.52 | +0.14 | buy |
| JUPITER ASSET MANAGEMENT LTD | 1,781,063 | 1,849,507 | +68,444 | 0.12 | 0.16 | +0.03 | buy |
| MORGAN STANLEY | 2,081,397 | 1,731,905 | -349,492 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 336,000 | 1,500,000 | +1,164,000 | 0.14 | 0.70 | +0.56 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 1,400,004 | +1,400,004 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 966,293 | 1,272,136 | +305,843 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 502,337 | 1,243,317 | +740,980 | 0.02 | 0.04 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,207,941 | +1,207,941 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 941,285 | 1,207,941 | +266,656 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.40 | +0.40 | buy |
| Woodline Partners LP | 200,998 | 1,075,349 | +874,351 | 0.01 | 0.06 | +0.05 | buy |
| STIFEL FINANCIAL CORP | 1,012,706 | 1,014,387 | +1,681 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,381,703 | 976,216 | -405,487 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 0 | 930,232 | +930,232 | 0.00 | 0.08 | +0.08 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 748,636 | 898,963 | +150,327 | 0.02 | 0.03 | +0.01 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 724,286 | 777,948 | +53,662 | 0.71 | 0.84 | +0.13 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 59,983 | 726,057 | +666,074 | 0.00 | 0.04 | +0.04 | buy |
| FEDERATED HERMES, INC. | 368,617 | 725,970 | +357,353 | 0.01 | 0.02 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 576,930 | 699,390 | +122,460 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 465,499 | 673,340 | +207,841 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 521,465 | 647,679 | +126,214 | 0.01 | 0.01 | +0.00 | buy |
| Marex Group plc | 623,600 | 623,600 | 0 | 0.08 | 0.08 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 579,430 | 577,825 | -1,605 | 0.00 | 0.01 | +0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 550,144 | 532,817 | -17,327 | 0.08 | 0.08 | +0.01 | sell |
| JPMORGAN CHASE & CO | 548,491 | 527,662 | -20,829 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 630,529 | 492,954 | -137,575 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 70,559 | 491,226 | +420,667 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 434,753 | 412,010 | -22,743 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 328,000 | 410,654 | +82,654 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 270,011 | 398,463 | +128,452 | 0.01 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 445,400 | 385,400 | -60,000 | 3.25 | 3.05 | -0.20 | sell |
| Nuveen, LLC | 240,817 | 377,646 | +136,829 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 333,897 | 376,980 | +43,083 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 355,000 | 355,000 | 0 | 0.34 | 0.30 | -0.04 | hold |
| FIRST TRUST ADVISORS LP | 0 | 339,807 | +339,807 | 0.00 | 0.00 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 145,512 | 339,024 | +193,512 | 0.02 | 0.06 | +0.04 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 429,540 | 326,893 | -102,647 | 0.42 | 0.34 | -0.08 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 283,958 | 312,809 | +28,851 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 730,122 | 298,380 | -431,742 | 0.08 | 0.04 | -0.05 | sell |
| Trexquant Investment LP | 0 | 298,174 | +298,174 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 217,800 | 257,100 | +39,300 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 245,000 | 250,000 | +5,000 | 0.41 | 0.38 | -0.03 | buy |
| AMERIPRISE FINANCIAL INC | 128,209 | 240,451 | +112,242 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 208,301 | 239,016 | +30,715 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 36,757 | 233,257 | +196,500 | 0.00 | 0.00 | +0.00 | buy |
| Canal Insurance CO | 230,000 | 230,000 | 0 | 0.63 | 0.85 | +0.22 | hold |
| Hennion & Walsh Asset Management, Inc. | 159,803 | 220,523 | +60,720 | 0.07 | 0.11 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 164,186 | 210,550 | +46,364 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 113,904 | 209,461 | +95,557 | 0.02 | 0.06 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 133,974 | 201,803 | +67,829 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 53,982 | 201,436 | +147,454 | 0.01 | 0.04 | +0.03 | buy |
| LPL Financial LLC | 122,861 | 191,480 | +68,619 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 186,781 | 190,673 | +3,892 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 142,798 | 190,611 | +47,813 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 167,807 | 188,207 | +20,400 | 0.05 | 0.06 | +0.01 | buy |
| SECTOR GAMMA AS | 0 | 185,177 | +185,177 | 0.00 | 0.68 | +0.68 | buy |
| RHUMBLINE ADVISERS | 136,588 | 176,725 | +40,137 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 458,241 | 164,712 | -293,529 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 137,425 | 164,078 | +26,653 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 199,758 | 159,581 | -40,177 | 0.01 | 0.01 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 18,210 | 152,612 | +134,402 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,259 | 152,517 | +14,258 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 147,242 | 151,569 | +4,327 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 103,100 | 143,350 | +40,250 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 141,523 | 141,890 | +367 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 261,864 | 127,649 | -134,215 | 0.02 | 0.01 | -0.01 | sell |
| Russell Investments Group, Ltd. | 59,432 | 126,011 | +66,579 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 89,223 | 116,908 | +27,685 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 93,645 | 114,006 | +20,361 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 90,049 | 113,828 | +23,779 | 0.04 | 0.06 | +0.02 | buy |
| OPPENHEIMER & CO INC | 106,924 | 107,453 | +529 | 0.02 | 0.02 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 109,290 | 105,211 | -4,079 | 0.00 | 0.00 | +0.00 | sell |
| Elmwood Wealth Management, Inc. | 102,924 | 102,944 | +20 | 0.36 | 0.44 | +0.07 | buy |
| Deuterium Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 1.83 | +1.83 | buy |
| D.A. DAVIDSON & CO. | 93,260 | 95,540 | +2,280 | 0.01 | 0.01 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 94,250 | +94,250 | 0.00 | 0.17 | +0.17 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 88,257 | +88,257 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 53,781 | 85,122 | +31,341 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 120,356 | 84,728 | -35,628 | 0.02 | 0.02 | -0.00 | sell |
| Caption Management, LLC | 0 | 84,700 | +84,700 | 0.00 | 0.05 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 93,620 | 84,379 | -9,241 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 89,688 | 82,966 | -6,722 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 73,340 | 81,430 | +8,090 | 0.01 | 0.01 | -0.00 | buy |
| BENJAMIN EDWARDS INC | 82,563 | 80,881 | -1,682 | 0.01 | 0.01 | +0.00 | sell |