| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ARK Investment Management LLC | 9,948,629 | 11,412,449 | +1,463,820 | 2.41 | 2.06 | -0.35 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,990 | 507,887 | +343,897 | 0.02 | 0.04 | 0.00 | buy |
| Casdin Capital, LLC | 1,178,075 | 1,450,000 | +271,925 | 4.12 | 4.34 | +0.22 | buy |
| Deep Track Capital, LP | 2,000,000 | 2,250,000 | +250,000 | 2.45 | 2.40 | -0.05 | buy |
| PDT Partners, LLC | 37,077 | 160,997 | +123,920 | 0.15 | 0.54 | +0.39 | buy |
| Rafferty Asset Management, LLC | 251,125 | 328,998 | +77,873 | 0.05 | 0.04 | -0.00 | buy |
| Rokos Capital Management LLP | 1,389,296 | 1,463,630 | +74,334 | 0.32 | 0.39 | +0.07 | buy |
| CAPITAL ADVISORS INC/OK | 211,359 | 284,738 | +73,379 | 0.18 | 0.19 | +0.02 | buy |
| Avidity Partners Management LP | 379,100 | 447,434 | +68,334 | 0.48 | 0.52 | +0.04 | buy |
| Granahan Investment Management, LLC | 205,191 | 257,791 | +52,600 | 0.23 | 0.26 | +0.03 | buy |
| Hudson Bay Capital Management LP | 185,200 | 237,500 | +52,300 | 0.05 | 0.05 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 129,699 | 88,502 | +41,197 | 0.01 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 51,275 | 91,275 | +40,000 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 31,436 | 67,252 | +35,816 | 0.01 | 0.03 | 0.00 | buy |
| Walleye Capital LLC | 183,455 | 203,327 | +19,872 | 0.11 | 0.12 | 0.00 | buy |
| Capital Impact Advisors, LLC | 11,378 | 26,128 | +14,750 | 0.60 | 1.05 | +0.45 | buy |
| Orchard Capital Management, LLC | 159,155 | 170,006 | +10,851 | 1.86 | 1.62 | -0.24 | buy |
| PROFUND ADVISORS LLC | 40,461 | 50,976 | +10,515 | 0.07 | 0.07 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 71,680 | 61,194 | +10,486 | 0.02 | 0.01 | 0.00 | sell |
| Resonant Capital Advisors, LLC | 31,266 | 41,348 | +10,082 | 0.11 | 0.12 | +0.02 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 49,332 | 59,380 | +10,048 | 0.04 | 0.03 | -0.01 | buy |
| Rockefeller Capital Management L.P. | 46,511 | 56,479 | +9,968 | 0.01 | 0.01 | 0.00 | buy |
| LMR Partners LLP | 18,690 | 27,490 | +8,800 | 0.02 | 0.02 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 10,756 | 19,038 | +8,282 | 0.10 | 0.15 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 2,263 | 10,355 | +8,092 | 0.02 | 0.06 | +0.04 | buy |
| Atom Investors LP | 14,035 | 20,282 | +6,247 | 0.10 | 0.11 | +0.01 | buy |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA | 111,440 | 117,315 | +5,875 | 0.45 | 0.45 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 18,899 | 23,848 | +4,949 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 50,750 | 55,650 | +4,900 | 0.51 | 0.49 | -0.02 | buy |
| CIBC WORLD MARKET INC. | 15,399 | 19,878 | +4,479 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 12,075 | 16,551 | +4,476 | 0.03 | 0.03 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 106,150 | 102,233 | +3,917 | 0.00 | 0.00 | 0.00 | sell |
| ProShare Advisors LLC | 17,443 | 20,769 | +3,326 | 0.00 | 0.00 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 16,604 | 19,384 | +2,780 | 0.11 | 0.11 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 53,018 | 54,822 | +1,804 | 0.62 | 0.52 | -0.11 | buy |
| SHELL ASSET MANAGEMENT CO | 24,421 | 22,801 | +1,620 | 0.03 | 0.03 | 0.00 | sell |
| CI INVESTMENTS INC. | 2,631 | 3,835 | +1,204 | 0.00 | 0.00 | 0.00 | buy |
| Cyndeo Wealth Partners, LLC | 7,236 | 8,236 | +1,000 | 0.02 | 0.02 | -0.00 | buy |
| NATIXIS | 3,201 | 2,234 | +967 | 0.00 | 0.00 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,192 | 2,906 | +714 | 0.04 | 0.06 | +0.01 | buy |
| Vident Advisory, LLC | 15,774 | 16,465 | +691 | 0.02 | 0.01 | 0.00 | buy |
| Interchange Capital Partners, LLC | 9,634 | 10,239 | +605 | 0.24 | 0.23 | -0.01 | buy |
| AXXCESS WEALTH MANAGEMENT, LLC | 14,998 | 15,592 | +594 | 0.02 | 0.01 | -0.00 | buy |
| AZZAD ASSET MANAGEMENT INC /ADV | 7,752 | 8,323 | +571 | 0.03 | 0.03 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,273 | 11,695 | +422 | 0.00 | 0.00 | 0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 1,022 | 1,402 | +380 | 0.00 | 0.00 | -0.00 | buy |
| Fort Sheridan Advisors LLC | 7,320 | 7,677 | +357 | 0.05 | 0.05 | -0.01 | buy |
| Arete Wealth Advisors, LLC | 7,038 | 7,220 | +182 | 0.04 | 0.02 | -0.02 | buy |
| Stone House Investment Management, LLC | 52 | 152 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 3,112 | 3,207 | +95 | 0.00 | 0.00 | -0.00 | buy |
| Elmwood Wealth Management, Inc. | 67,899 | 67,909 | +10 | 1.04 | 1.45 | +0.42 | buy |
| Relyea Zuckerberg Hanson LLC | 13,216 | 13,218 | +2 | 0.10 | 0.08 | -0.02 | buy |
| WOLFF WIESE MAGANA LLC | 160 | 130 | -30 | 0.00 | 0.00 | -0.00 | sell |
| C M BIDWELL & ASSOCIATES LTD | 51 | 12 | -39 | 0.00 | 0.00 | -0.00 | sell |
| FDx Advisors, Inc. | 10,576 | 10,321 | -255 | 0.00 | 0.02 | +0.02 | sell |
| BENJAMIN EDWARDS INC | 844 | 527 | -317 | 0.01 | 0.00 | -0.00 | sell |
| Waverly Advisors, LLC | 7,082 | 6,735 | -347 | 0.01 | 0.01 | -0.00 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 15,000 | 14,396 | -604 | 0.01 | 0.01 | -0.00 | sell |
| KRAEMATON INVESTMENT ADVISORS, INC | 11,530 | 10,690 | -840 | 0.45 | 0.36 | -0.09 | sell |
| Corton Capital Inc. | 14,088 | 10,186 | -3,902 | 0.22 | 0.10 | -0.13 | sell |
| Green Alpha Advisors, LLC | 14,777 | 10,103 | -4,674 | 0.36 | 0.22 | -0.14 | sell |
| Chevy Chase Trust Holdings, LLC | 1,002,955 | 991,175 | -11,780 | 0.13 | 0.11 | -0.02 | sell |
| McGuire Investment Group, LLC | 65,984 | 50,509 | -15,475 | 0.40 | 0.26 | -0.15 | sell |
| Nikko Asset Management Americas, Inc. | 3,520,295 | 3,478,562 | -41,733 | 1.33 | 1.02 | -0.31 | sell |
| TWINBEECH CAPITAL LP | 99,280 | 17,014 | -82,266 | 0.06 | 0.01 | -0.05 | sell |
| SECTORAL ASSET MANAGEMENT INC | 112,332 | 9,300 | -103,032 | 0.69 | 0.12 | -0.57 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 1,145,091 | 1,030,621 | -114,470 | 3.72 | 2.85 | -0.86 | sell |
| MPM BioImpact LLC | 544,639 | 382,598 | -162,041 | 4.60 | 2.73 | -1.87 | sell |
| TANG CAPITAL MANAGEMENT LLC | 397,600 | 200,000 | -197,600 | 1.77 | 0.56 | -1.21 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,049,220 | 1,834,143 | -215,077 | 0.01 | 0.01 | -0.00 | sell |