| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 6,726,491 | 6,726,491 | 0 | 7.19 | 7.05 | -0.14 | hold |
| VANGUARD GROUP INC | 4,851,390 | 6,299,556 | +1,448,166 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,832,123 | 4,368,418 | +536,295 | 0.02 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 4,213,483 | 3,297,897 | -915,586 | 2.71 | 2.01 | -0.70 | sell |
| Avidity Partners Management LP | 2,985,117 | 2,985,190 | +73 | 4.70 | 4.38 | -0.32 | buy |
| Paradigm Biocapital Advisors LP | 931,303 | 2,614,935 | +1,683,632 | 1.80 | 3.80 | +2.00 | buy |
| Bellevue Group AG | 2,507,731 | 2,390,800 | -116,931 | 1.58 | 1.51 | -0.07 | sell |
| FMR LLC | 2,244,019 | 2,388,954 | +144,935 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,439,981 | 2,280,613 | -159,368 | 0.10 | 0.09 | -0.01 | sell |
| JPMORGAN CHASE & CO | 2,172,829 | 1,699,843 | -472,986 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 1,186,474 | 1,382,167 | +195,693 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,122,627 | 1,313,316 | +190,689 | 0.00 | 0.01 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,289,521 | 1,289,521 | 0 | 42.75 | 46.59 | +3.84 | hold |
| Commodore Capital LP | 1,000,000 | 1,275,000 | +275,000 | 3.60 | 3.52 | -0.08 | buy |
| PERCEPTIVE ADVISORS LLC | 354,082 | 1,236,603 | +882,521 | 0.33 | 0.90 | +0.57 | buy |
| ArrowMark Colorado Holdings LLC | 1,569,895 | 1,205,568 | -364,327 | 0.71 | 0.56 | -0.15 | sell |
| NORGES BANK | 877,708 | 1,108,768 | +231,060 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 693,479 | 675,509 | -17,970 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 789,485 | 630,000 | -159,485 | 0.07 | 0.05 | -0.02 | sell |
| VR Adviser, LLC | 627,788 | 627,788 | 0 | 1.77 | 1.23 | -0.54 | hold |
| GOLDMAN SACHS GROUP INC | 329,459 | 594,403 | +264,944 | 0.00 | 0.01 | +0.00 | buy |
| Finepoint Capital LP | 504,700 | 539,100 | +34,400 | 7.19 | 5.71 | -1.48 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 469,474 | 528,055 | +58,581 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 491,235 | 509,127 | +17,892 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 487,555 | 462,554 | -25,001 | 0.14 | 0.12 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 491,877 | 434,300 | -57,577 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 387,630 | 422,204 | +34,574 | 0.17 | 0.16 | -0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 421,348 | 421,348 | 0 | 0.27 | 0.22 | -0.05 | hold |
| Aquilo Capital Management, LLC | 489,153 | 405,766 | -83,387 | 14.12 | 12.55 | -1.56 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 309,663 | 379,376 | +69,713 | 0.05 | 0.06 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 237,573 | 361,973 | +124,400 | 0.02 | 0.02 | +0.01 | buy |
| Opaleye Management Inc. | 263,700 | 330,000 | +66,300 | 2.89 | 2.97 | +0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 395,367 | 325,518 | -69,849 | 0.01 | 0.01 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 333,524 | 324,844 | -8,680 | 0.19 | 0.17 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 84,931 | 303,638 | +218,707 | 0.01 | 0.02 | +0.01 | buy |
| UBS Group AG | 256,986 | 294,044 | +37,058 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 285,331 | 285,331 | 0 | 0.63 | 0.50 | -0.13 | hold |
| Schonfeld Strategic Advisors LLC | 245,868 | 281,097 | +35,229 | 0.08 | 0.09 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 278,737 | 276,482 | -2,255 | 0.01 | 0.01 | -0.00 | sell |
| BROWN ADVISORY INC | 265,431 | 274,175 | +8,744 | 0.02 | 0.02 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 15,211 | 268,153 | +252,942 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 358,813 | 243,667 | -115,146 | 0.01 | 0.01 | -0.01 | sell |
| WASATCH ADVISORS LP | 222,942 | 207,426 | -15,516 | 0.05 | 0.04 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 146,948 | 199,348 | +52,400 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 232,617 | 194,496 | -38,121 | 0.00 | 0.00 | -0.00 | sell |
| Amundi | 195,720 | 193,341 | -2,379 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 80,000 | 180,000 | +100,000 | 0.30 | 0.77 | +0.47 | buy |
| Bank of New York Mellon Corp | 187,303 | 177,261 | -10,042 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 138,028 | 171,963 | +33,935 | 0.01 | 0.02 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 134,270 | 170,000 | +35,730 | 0.55 | 0.67 | +0.11 | buy |
| PANAGORA ASSET MANAGEMENT INC | 18,407 | 163,090 | +144,683 | 0.00 | 0.04 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 155,036 | 154,486 | -550 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 197,052 | 147,255 | -49,797 | 0.01 | 0.01 | -0.01 | sell |
| YALE UNIVERSITY | 143,522 | 143,522 | 0 | 5.23 | 14.83 | +9.60 | hold |
| BIT Capital GmbH | 135,722 | 142,706 | +6,984 | 0.60 | 0.52 | -0.08 | buy |
| FIRST TRUST ADVISORS LP | 0 | 139,313 | +139,313 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 85,996 | 134,955 | +48,959 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 167,001 | 124,979 | -42,022 | 0.97 | 0.63 | -0.34 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 89,228 | 119,481 | +30,253 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 10,198 | 114,401 | +104,203 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 89,500 | 114,100 | +24,600 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 97,217 | 109,678 | +12,461 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 105,919 | +105,919 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 61,243 | 102,373 | +41,130 | 0.06 | 0.08 | +0.03 | buy |
| BANQUE PICTET & CIE SA | 92,933 | 84,920 | -8,013 | 0.04 | 0.04 | -0.01 | sell |
| Squarepoint Ops LLC | 6,602 | 81,871 | +75,269 | 0.00 | 0.01 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 71,570 | 76,990 | +5,420 | 0.13 | 0.13 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,163 | 76,637 | +17,474 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 71,695 | 75,821 | +4,126 | 0.04 | 0.03 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 75,551 | +75,551 | 0.00 | 0.03 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 0 | 74,443 | +74,443 | 0.00 | 0.06 | +0.06 | buy |
| AMERIPRISE FINANCIAL INC | 73,975 | 74,393 | +418 | 0.00 | 0.00 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 74,000 | 74,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RHUMBLINE ADVISERS | 68,890 | 71,205 | +2,315 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 234,082 | 71,113 | -162,969 | 1.64 | 0.46 | -1.18 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 67,703 | +67,703 | 0.00 | 0.06 | +0.06 | buy |
| Hennion & Walsh Asset Management, Inc. | 36,084 | 61,862 | +25,778 | 0.08 | 0.14 | +0.05 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 60,873 | 60,873 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 37,291 | 58,519 | +21,228 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 46,726 | 57,688 | +10,962 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 57,500 | 57,500 | 0 | 1.09 | 0.93 | -0.16 | hold |
| State of New Jersey Common Pension Fund D | 0 | 57,145 | +57,145 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,562 | 57,059 | +8,497 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 52,500 | 56,470 | +3,970 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 56,754 | 56,370 | -384 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 38,087 | 56,134 | +18,047 | 0.17 | 0.22 | +0.05 | buy |
| BARCLAYS PLC | 83,621 | 55,474 | -28,147 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,096 | 53,711 | +2,615 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 53,203 | +53,203 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 0 | 51,122 | +51,122 | 0.00 | 0.75 | +0.75 | buy |
| Yelin Lapidot Holdings Management Ltd. | 49,503 | 49,503 | 0 | 0.49 | 0.42 | -0.07 | hold |
| Engineers Gate Manager LP | 10,764 | 49,324 | +38,560 | 0.01 | 0.05 | +0.04 | buy |
| SECTORAL ASSET MANAGEMENT INC | 66,000 | 48,780 | -17,220 | 1.17 | 0.79 | -0.38 | sell |
| ALGERT GLOBAL LLC | 74,571 | 48,195 | -26,376 | 0.12 | 0.08 | -0.05 | sell |
| ALPS ADVISORS INC | 35,397 | 48,023 | +12,626 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 47,400 | +47,400 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 42,000 | 42,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Campbell & CO Investment Adviser LLC | 0 | 40,216 | +40,216 | 0.00 | 0.14 | +0.14 | buy |
| Artia Global Partners LP | 0 | 40,000 | +40,000 | 0.00 | 0.41 | +0.41 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 6,406 | 38,988 | +32,582 | 0.00 | 0.00 | +0.00 | buy |