| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 931,303 | 2,614,935 | +1,683,632 | 1.80 | 3.80 | +2.00 | buy |
| VANGUARD GROUP INC | 4,851,390 | 6,299,556 | +1,448,166 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 354,082 | 1,236,603 | +882,521 | 0.33 | 0.90 | +0.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,832,123 | 4,368,418 | +536,295 | 0.02 | 0.02 | +0.00 | buy |
| Commodore Capital LP | 1,000,000 | 1,275,000 | +275,000 | 3.60 | 3.52 | -0.08 | buy |
| GOLDMAN SACHS GROUP INC | 329,459 | 594,403 | +264,944 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 15,211 | 268,153 | +252,942 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 877,708 | 1,108,768 | +231,060 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 84,931 | 303,638 | +218,707 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 1,186,474 | 1,382,167 | +195,693 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,122,627 | 1,313,316 | +190,689 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 2,244,019 | 2,388,954 | +144,935 | 0.01 | 0.01 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 18,407 | 163,090 | +144,683 | 0.00 | 0.04 | +0.03 | buy |
| FIRST TRUST ADVISORS LP | 0 | 139,313 | +139,313 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 237,573 | 361,973 | +124,400 | 0.02 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 105,919 | +105,919 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 10,198 | 114,401 | +104,203 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 80,000 | 180,000 | +100,000 | 0.30 | 0.77 | +0.47 | buy |
| Verition Fund Management LLC | 0 | 75,551 | +75,551 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 6,602 | 81,871 | +75,269 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 0 | 74,443 | +74,443 | 0.00 | 0.06 | +0.06 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 309,663 | 379,376 | +69,713 | 0.05 | 0.06 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 67,703 | +67,703 | 0.00 | 0.06 | +0.06 | buy |
| Opaleye Management Inc. | 263,700 | 330,000 | +66,300 | 2.89 | 2.97 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 469,474 | 528,055 | +58,581 | 0.00 | 0.01 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 57,145 | +57,145 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 53,203 | +53,203 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 146,948 | 199,348 | +52,400 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 51,122 | +51,122 | 0.00 | 0.75 | +0.75 | buy |
| DEUTSCHE BANK AG\ | 85,996 | 134,955 | +48,959 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 47,400 | +47,400 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 61,243 | 102,373 | +41,130 | 0.06 | 0.08 | +0.03 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 40,216 | +40,216 | 0.00 | 0.14 | +0.14 | buy |
| Artia Global Partners LP | 0 | 40,000 | +40,000 | 0.00 | 0.41 | +0.41 | buy |
| Engineers Gate Manager LP | 10,764 | 49,324 | +38,560 | 0.01 | 0.05 | +0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 37,505 | +37,505 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 256,986 | 294,044 | +37,058 | 0.00 | 0.00 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 134,270 | 170,000 | +35,730 | 0.55 | 0.67 | +0.11 | buy |
| Schonfeld Strategic Advisors LLC | 245,868 | 281,097 | +35,229 | 0.08 | 0.09 | +0.01 | buy |
| Woodline Partners LP | 387,630 | 422,204 | +34,574 | 0.17 | 0.16 | -0.01 | buy |
| Finepoint Capital LP | 504,700 | 539,100 | +34,400 | 7.19 | 5.71 | -1.48 | buy |
| FEDERATED HERMES, INC. | 138,028 | 171,963 | +33,935 | 0.01 | 0.02 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 6,406 | 38,988 | +32,582 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 89,228 | 119,481 | +30,253 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 6,456 | 36,297 | +29,841 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 26,200 | +26,200 | 0.00 | 0.30 | +0.30 | buy |
| Hennion & Walsh Asset Management, Inc. | 36,084 | 61,862 | +25,778 | 0.08 | 0.14 | +0.05 | buy |
| Swiss National Bank | 89,500 | 114,100 | +24,600 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 11,015 | 34,588 | +23,573 | 0.01 | 0.02 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 37,291 | 58,519 | +21,228 | 0.00 | 0.00 | +0.00 | buy |
| Magnetar Financial LLC | 0 | 19,747 | +19,747 | 0.00 | 0.02 | +0.02 | buy |
| PDT Partners, LLC | 38,087 | 56,134 | +18,047 | 0.17 | 0.22 | +0.05 | buy |
| NORTHERN TRUST CORP | 491,235 | 509,127 | +17,892 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,163 | 76,637 | +17,474 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 17,044 | +17,044 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 7,670 | 24,501 | +16,831 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 14,400 | +14,400 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 35,397 | 48,023 | +12,626 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 97,217 | 109,678 | +12,461 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 20,909 | 32,429 | +11,520 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 11,482 | +11,482 | 0.00 | 0.25 | +0.25 | buy |
| Legal & General Group Plc | 46,726 | 57,688 | +10,962 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 9,806 | +9,806 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 265,431 | 274,175 | +8,744 | 0.02 | 0.02 | -0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 8,697 | +8,697 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,562 | 57,059 | +8,497 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 8,085 | +8,085 | 0.00 | 0.00 | +0.00 | buy |
| KPP Advisory Services LLC | 0 | 8,064 | +8,064 | 0.00 | 0.09 | +0.09 | buy |
| Edgestream Partners, L.P. | 0 | 8,006 | +8,006 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 0 | 7,727 | +7,727 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 11,725 | 19,125 | +7,400 | 0.00 | 0.00 | +0.00 | buy |
| COOKSON PEIRCE & CO INC | 0 | 7,000 | +7,000 | 0.00 | 0.02 | +0.02 | buy |
| BIT Capital GmbH | 135,722 | 142,706 | +6,984 | 0.60 | 0.52 | -0.08 | buy |
| China Universal Asset Management Co., Ltd. | 6,370 | 13,064 | +6,694 | 0.05 | 0.07 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 5,349 | 11,638 | +6,289 | 0.00 | 0.00 | +0.00 | buy |
| CULLINAN ASSOCIATES INC | 0 | 6,000 | +6,000 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 5,881 | +5,881 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 5,061 | 10,809 | +5,748 | 0.01 | 0.02 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 71,570 | 76,990 | +5,420 | 0.13 | 0.13 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 0 | 5,000 | +5,000 | 0.00 | 4.99 | +4.99 | buy |
| Centiva Capital, LP | 0 | 4,970 | +4,970 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 4,928 | +4,928 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 18,167 | 22,325 | +4,158 | 0.14 | 0.12 | -0.02 | buy |
| ZACKS INVESTMENT MANAGEMENT | 71,695 | 75,821 | +4,126 | 0.04 | 0.03 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 52,500 | 56,470 | +3,970 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 6,864 | 10,152 | +3,288 | 0.03 | 0.03 | -0.00 | buy |
| Arizona State Retirement System | 12,709 | 15,885 | +3,176 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,096 | 53,711 | +2,615 | 0.01 | 0.01 | -0.00 | buy |
| LPL Financial LLC | 13,274 | 15,886 | +2,612 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,080 | 16,670 | +2,590 | 0.00 | 0.00 | -0.00 | buy |
| WOLVERINE TRADING, LLC | 9,787 | 12,269 | +2,482 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 2,383 | +2,383 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,520 | 12,864 | +2,344 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 68,890 | 71,205 | +2,315 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 11,644 | 13,832 | +2,188 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 27,889 | 29,882 | +1,993 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 0 | 1,630 | +1,630 | 0.00 | 0.00 | +0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 1,074 | +1,074 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 11,510 | 12,570 | +1,060 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 0 | 841 | +841 | 0.00 | 0.00 | +0.00 | buy |