| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 931,303 | 2,614,935 | +1,683,632 | 1.80 | 3.80 | +2.00 | buy |
| PERCEPTIVE ADVISORS LLC | 354,082 | 1,236,603 | +882,521 | 0.33 | 0.89 | +0.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,832,123 | 4,368,418 | +536,295 | 0.02 | 0.02 | +0.00 | buy |
| Commodore Capital LP | 1,000,000 | 1,275,000 | +275,000 | 3.60 | 3.52 | -0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 237,573 | 361,973 | +124,400 | 0.02 | 0.03 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 80,000 | 180,000 | +100,000 | 0.30 | 0.77 | +0.47 | buy |
| Opaleye Management Inc. | 263,700 | 330,000 | +66,300 | 2.89 | 2.97 | +0.08 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 91,132 | 31,501 | +59,631 | 0.27 | 0.09 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 146,948 | 199,348 | +52,400 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 134,270 | 170,000 | +35,730 | 0.55 | 0.67 | +0.11 | buy |
| Woodline Partners LP | 387,630 | 422,204 | +34,574 | 0.17 | 0.16 | -0.01 | buy |
| Finepoint Capital LP | 504,700 | 539,100 | +34,400 | 6.55 | 5.71 | -0.85 | buy |
| ALGERT GLOBAL LLC | 74,571 | 48,195 | +26,376 | 0.12 | 0.08 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 36,084 | 61,862 | +25,778 | 0.08 | 0.14 | +0.05 | buy |
| PDT Partners, LLC | 38,087 | 56,134 | +18,047 | 0.17 | 0.22 | +0.05 | buy |
| ALPS ADVISORS INC | 35,397 | 48,023 | +12,626 | 0.01 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 135,722 | 142,706 | +6,984 | 0.55 | 0.44 | -0.11 | buy |
| China Universal Asset Management Co., Ltd. | 6,370 | 13,064 | +6,694 | 0.05 | 0.07 | +0.02 | buy |
| CASTLEARK MANAGEMENT LLC | 71,570 | 76,990 | +5,420 | 0.13 | 0.13 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 18,167 | 22,325 | +4,158 | 0.14 | 0.12 | -0.02 | buy |
| ZACKS INVESTMENT MANAGEMENT | 71,695 | 75,821 | +4,126 | 0.04 | 0.03 | -0.00 | buy |
| NEOS Investment Management LLC | 6,864 | 10,152 | +3,288 | 0.03 | 0.03 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 27,889 | 29,882 | +1,993 | 0.00 | 0.00 | 0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 6,733 | 6,117 | +616 | 0.01 | 0.01 | 0.00 | sell |
| Bank Julius Baer & Co. Ltd, Zurich | 16,000 | 16,330 | +330 | 0.01 | 0.00 | -0.01 | buy |
| Avidity Partners Management LP | 2,985,117 | 2,985,190 | +73 | 4.70 | 4.38 | -0.32 | buy |
| VIRTUS ADVISERS, LLC | 2,595 | 2,431 | -164 | 0.07 | 0.05 | -0.01 | sell |
| Bank Pictet & Cie (Europe) AG | 7,073 | 6,734 | -339 | 0.01 | 0.01 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 10,759 | 9,198 | -1,561 | 0.11 | 0.08 | -0.03 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 278,737 | 276,482 | -2,255 | 0.01 | 0.01 | -0.00 | sell |
| FORA Capital, LLC | 21,228 | 18,895 | -2,333 | 0.08 | 0.06 | -0.01 | sell |
| E. Ohman J:or Asset Management AB | 27,500 | 20,229 | -7,271 | 0.04 | 0.02 | -0.02 | sell |
| BANQUE PICTET & CIE SA | 92,933 | 84,920 | -8,013 | 0.03 | 0.03 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 333,524 | 324,844 | -8,680 | 0.19 | 0.17 | -0.02 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 15,844 | 5,060 | -10,784 | 0.09 | 0.04 | -0.05 | sell |
| Corton Capital Inc. | 27,199 | 14,935 | -12,264 | 0.36 | 0.23 | -0.13 | sell |
| WASATCH ADVISORS LP | 222,942 | 207,426 | -15,516 | 0.05 | 0.04 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 66,000 | 48,780 | -17,220 | 1.17 | 0.79 | -0.38 | sell |
| Capital Impact Advisors, LLC | 30,531 | 12,710 | -17,821 | 1.65 | 0.68 | -0.97 | sell |
| Candriam S.C.A. | 487,555 | 462,554 | -25,001 | 0.14 | 0.12 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 46,761 | 10,450 | -36,311 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 167,001 | 124,979 | -42,022 | 0.97 | 0.63 | -0.34 | sell |
| Aquilo Capital Management, LLC | 489,153 | 405,766 | -83,387 | 14.12 | 12.55 | -1.56 | sell |
| Bellevue Group AG | 2,507,731 | 2,390,800 | -116,931 | 1.58 | 1.51 | -0.07 | sell |
| CITADEL ADVISORS LLC | 2,439,981 | 2,280,613 | -159,368 | 0.14 | 0.13 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 789,485 | 630,000 | -159,485 | 0.07 | 0.05 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 234,082 | 71,113 | -162,969 | 1.64 | 0.46 | -1.18 | sell |
| ArrowMark Colorado Holdings LLC | 1,569,895 | 1,205,568 | -364,327 | 0.71 | 0.56 | -0.15 | sell |
| RTW INVESTMENTS, LP | 4,213,483 | 3,297,897 | -915,586 | 2.71 | 2.01 | -0.70 | sell |