| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 1,625,000 | 1,975,000 | +350,000 | 5.89 | 3.09 | -2.80 | buy |
| Monaco Asset Management SAM | 25,000 | 315,459 | +290,459 | 0.21 | 1.12 | +0.91 | buy |
| ALGERT GLOBAL LLC | 205,988 | 463,867 | +257,879 | 0.09 | 0.08 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 208,992 | 375,027 | +166,035 | 0.09 | 0.06 | -0.03 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 80,000 | 130,000 | +50,000 | 0.03 | 0.02 | -0.01 | buy |
| Aquilo Capital Management, LLC | 328,766 | 360,766 | +32,000 | 10.79 | 6.83 | -3.96 | buy |
| Rhenman & Partners Asset Management AB | 155,500 | 183,000 | +27,500 | 0.31 | 0.15 | -0.16 | buy |
| NEOS Investment Management LLC | 11,835 | 38,315 | +26,480 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 11,835 | 38,315 | +26,480 | 0.09 | 0.08 | -0.01 | buy |
| PROFUND ADVISORS LLC | 12,052 | 30,629 | +18,577 | 0.01 | 0.01 | +0.00 | buy |
| Birchview Capital, LP | 15,000 | 30,000 | +15,000 | 0.23 | 0.18 | -0.05 | buy |
| Capula Management Ltd | 10,758 | 16,830 | +6,072 | 0.00 | 0.00 | -0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 86,448 | 91,791 | +5,343 | 0.02 | 0.01 | -0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 186,594 | 190,582 | +3,988 | 0.04 | 0.02 | -0.02 | buy |
| Woodline Partners LP | 692,733 | 695,945 | +3,212 | 0.09 | 0.03 | -0.06 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 232,886 | 234,106 | +1,220 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,443 | 1,759 | +316 | 0.00 | 0.00 | -0.00 | buy |
| Yelin Lapidot Holdings Management Ltd. | 46,873 | 46,665 | -208 | 0.16 | 0.06 | -0.09 | sell |
| China Universal Asset Management Co., Ltd. | 14,570 | 13,794 | -776 | 0.03 | 0.01 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 63,477 | 61,877 | -1,600 | 0.06 | 0.02 | -0.04 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 65,400 | 63,740 | -1,660 | 0.11 | 0.05 | -0.06 | sell |
| BANQUE PICTET & CIE SA | 110,619 | 99,287 | -11,332 | 0.01 | 0.01 | -0.01 | sell |
| HighVista Strategies LLC | 58,001 | 41,271 | -16,730 | 0.41 | 0.11 | -0.30 | sell |
| SECTORAL ASSET MANAGEMENT INC | 30,150 | 12,930 | -17,220 | 0.39 | 0.07 | -0.32 | sell |
| Finepoint Capital LP | 713,778 | 694,028 | -19,750 | 0.84 | 0.37 | -0.46 | sell |
| Exome Asset Management LLC | 218,700 | 195,295 | -23,405 | 3.15 | 1.23 | -1.93 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 90,870 | 24,819 | -66,051 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,103,011 | 3,825,064 | -277,947 | 0.01 | 0.00 | -0.01 | sell |
| Avidity Partners Management LP | 1,358,000 | 413,162 | -944,838 | 2.60 | 0.60 | -2.00 | sell |
| T. Rowe Price Investment Management, Inc. | 2,208,234 | 548,104 | -1,660,130 | 0.03 | 0.00 | -0.02 | sell |