| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 1,275,000 | 1,884,361 | +609,361 | 3.52 | 3.42 | -0.10 | buy |
| CITADEL ADVISORS LLC | 2,280,613 | 2,639,499 | +358,886 | 0.13 | 0.10 | -0.03 | buy |
| Opaleye Management Inc. | 330,000 | 555,000 | +225,000 | 2.97 | 3.38 | +0.41 | buy |
| Candriam S.C.A. | 462,554 | 610,458 | +147,904 | 0.12 | 0.10 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 67,703 | 212,354 | +144,651 | 0.06 | 0.12 | +0.06 | buy |
| WASATCH ADVISORS LP | 207,426 | 275,433 | +68,007 | 0.04 | 0.04 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 170,000 | 230,000 | +60,000 | 0.67 | 0.59 | -0.08 | buy |
| Finepoint Capital LP | 539,100 | 574,378 | +35,278 | 5.71 | 4.34 | -1.37 | buy |
| Aquilo Capital Management, LLC | 405,766 | 428,766 | +23,000 | 12.55 | 11.00 | -1.55 | buy |
| Magnetar Financial LLC | 19,747 | 41,992 | +22,245 | 0.02 | 0.02 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 1,205,568 | 1,226,727 | +21,159 | 0.56 | 0.39 | -0.17 | buy |
| NEOS Investment Management LLC | 10,152 | 20,032 | +9,880 | 0.03 | 0.02 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 26,200 | 32,400 | +6,200 | 0.30 | 0.17 | -0.12 | buy |
| ZACKS INVESTMENT MANAGEMENT | 75,821 | 81,798 | +5,977 | 0.03 | 0.02 | -0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 60,873 | 66,647 | +5,774 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 48,023 | 53,365 | +5,342 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 10,809 | 15,954 | +5,145 | 0.02 | 0.02 | 0.00 | buy |
| E. Ohman J:or Asset Management AB | 20,229 | 24,830 | +4,601 | 0.02 | 0.02 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 61,862 | 65,907 | +4,045 | 0.14 | 0.09 | -0.05 | buy |
| ALGERT GLOBAL LLC | 48,195 | 44,448 | +3,747 | 0.08 | 0.04 | 0.00 | sell |
| Avidity Partners Management LP | 2,985,190 | 2,987,845 | +2,655 | 4.38 | 3.38 | -1.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,074 | 2,901 | +1,827 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 29,882 | 28,422 | +1,460 | 0.00 | 0.00 | 0.00 | sell |
| Edgestream Partners, L.P. | 8,006 | 9,311 | +1,305 | 0.02 | 0.01 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 31,501 | 30,301 | +1,200 | 0.09 | 0.05 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,431 | 3,423 | +992 | 0.05 | 0.04 | -0.01 | buy |
| Woodline Partners LP | 422,204 | 423,124 | +920 | 0.16 | 0.11 | -0.05 | buy |
| Parkman Healthcare Partners LLC | 124,979 | 125,161 | +182 | 0.63 | 0.45 | -0.18 | buy |
| BANQUE PICTET & CIE SA | 84,920 | 82,369 | -2,551 | 0.03 | 0.02 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 13,064 | 8,040 | -5,024 | 0.07 | 0.03 | -0.04 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 74,000 | 60,500 | -13,500 | 0.01 | 0.00 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 48,780 | 34,830 | -13,950 | 0.79 | 0.38 | -0.41 | sell |
| GILDER GAGNON HOWE & CO LLC | 324,844 | 285,099 | -39,745 | 0.17 | 0.10 | -0.07 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 276,482 | 236,174 | -40,308 | 0.01 | 0.01 | -0.01 | sell |
| BIT Capital GmbH | 142,706 | 80,972 | -61,734 | 0.44 | 0.17 | -0.27 | sell |
| TD ASSET MANAGEMENT INC | 199,348 | 91,548 | -107,800 | 0.01 | 0.00 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 2,614,935 | 2,438,149 | -176,786 | 3.80 | 2.48 | -1.32 | sell |
| PERCEPTIVE ADVISORS LLC | 1,236,603 | 1,027,749 | -208,854 | 0.89 | 0.66 | -0.23 | sell |
| RTW INVESTMENTS, LP | 3,297,897 | 2,967,897 | -330,000 | 2.01 | 1.22 | -0.79 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,368,418 | 3,988,869 | -379,549 | 0.02 | 0.01 | -0.01 | sell |