| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 1,275,000 | 1,884,361 | +609,361 | 3.52 | 3.42 | -0.10 | buy |
| BRAIDWELL LP | 0 | 517,230 | +517,230 | 0.00 | 0.43 | +0.43 | buy |
| VANGUARD GROUP INC | 6,299,556 | 6,671,821 | +372,265 | 0.01 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,280,613 | 2,639,499 | +358,886 | 0.09 | 0.07 | -0.02 | buy |
| STATE STREET CORP | 1,382,167 | 1,699,688 | +317,521 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 2,388,954 | 2,679,287 | +290,333 | 0.01 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,699,843 | 1,961,960 | +262,117 | 0.01 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 194,496 | 431,176 | +236,680 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,313,316 | 1,541,737 | +228,421 | 0.01 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 330,000 | 555,000 | +225,000 | 2.97 | 3.38 | +0.41 | buy |
| Qube Research & Technologies Ltd | 114,401 | 299,745 | +185,344 | 0.01 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 153,448 | +153,448 | 0.00 | 0.03 | +0.03 | buy |
| Candriam S.C.A. | 462,554 | 610,458 | +147,904 | 0.12 | 0.10 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 67,703 | 212,354 | +144,651 | 0.06 | 0.12 | +0.06 | buy |
| MORGAN STANLEY | 675,509 | 779,791 | +104,282 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 56,370 | 151,245 | +94,875 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 163,090 | 256,658 | +93,568 | 0.04 | 0.03 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 17,000 | 108,444 | +91,444 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 82,400 | +82,400 | 0.00 | 1.95 | +1.95 | buy |
| TWO SIGMA INVESTMENTS, LP | 105,919 | 178,326 | +72,407 | 0.01 | 0.01 | +0.00 | buy |
| WASATCH ADVISORS LP | 207,426 | 275,433 | +68,007 | 0.04 | 0.04 | -0.01 | buy |
| Aberdeen Group plc | 0 | 61,492 | +61,492 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 170,000 | 230,000 | +60,000 | 0.67 | 0.59 | -0.08 | buy |
| Bank of New York Mellon Corp | 177,261 | 235,096 | +57,835 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 17,169 | 73,382 | +56,213 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 134,955 | 186,407 | +51,452 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 36,297 | 86,096 | +49,799 | 0.01 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 17,044 | 64,106 | +47,062 | 0.02 | 0.06 | +0.04 | buy |
| BROWN ADVISORY INC | 274,175 | 316,138 | +41,963 | 0.02 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 81,871 | 118,899 | +37,028 | 0.01 | 0.01 | -0.00 | buy |
| Finepoint Capital LP | 539,100 | 574,378 | +35,278 | 5.71 | 4.34 | -1.37 | buy |
| Jump Financial, LLC | 0 | 31,762 | +31,762 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 434,300 | 463,935 | +29,635 | 0.00 | 0.00 | -0.00 | buy |
| Capula Management Ltd | 0 | 24,752 | +24,752 | 0.00 | 0.01 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 24,565 | +24,565 | 0.00 | 0.01 | +0.01 | buy |
| Aquilo Capital Management, LLC | 405,766 | 428,766 | +23,000 | 12.55 | 11.00 | -1.55 | buy |
| Magnetar Financial LLC | 19,747 | 41,992 | +22,245 | 0.02 | 0.02 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 1,205,568 | 1,226,727 | +21,159 | 0.56 | 0.39 | -0.17 | buy |
| AMERIPRISE FINANCIAL INC | 74,393 | 94,658 | +20,265 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 20,200 | +20,200 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 19,607 | +19,607 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 109,678 | 129,248 | +19,570 | 0.01 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 19,550 | +19,550 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 71,205 | 90,229 | +19,024 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 56,470 | 73,720 | +17,250 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 16,837 | +16,837 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 528,055 | 544,503 | +16,448 | 0.01 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 53,711 | 69,842 | +16,131 | 0.01 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 75,551 | 91,351 | +15,800 | 0.03 | 0.02 | -0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 38,988 | 53,912 | +14,924 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 11,969 | +11,969 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 26,183 | 37,180 | +10,997 | 0.01 | 0.01 | -0.00 | buy |
| NEOS Investment Management LLC | 10,152 | 20,032 | +9,880 | 0.03 | 0.02 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 40,216 | 48,271 | +8,055 | 0.14 | 0.11 | -0.03 | buy |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 0 | 6,938 | +6,938 | 0.00 | 0.04 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,188 | 26,425 | +6,237 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 26,200 | 32,400 | +6,200 | 0.30 | 0.17 | -0.12 | buy |
| ZACKS INVESTMENT MANAGEMENT | 75,821 | 81,798 | +5,977 | 0.03 | 0.02 | -0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 60,873 | 66,647 | +5,774 | 0.01 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 7,727 | 13,238 | +5,511 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 49,324 | 54,759 | +5,435 | 0.05 | 0.03 | -0.02 | buy |
| WELLS FARGO & COMPANY/MN | 76,637 | 82,058 | +5,421 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 48,023 | 53,365 | +5,342 | 0.01 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 1,680 | 6,913 | +5,233 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 10,809 | 15,954 | +5,145 | 0.02 | 0.02 | -0.00 | buy |
| Rafferty Asset Management, LLC | 8,085 | 13,078 | +4,993 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 867 | 5,713 | +4,846 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 21,702 | 26,459 | +4,757 | 0.00 | 0.00 | -0.00 | buy |
| E. Ohman J:or Asset Management AB | 20,229 | 24,830 | +4,601 | 0.02 | 0.02 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 4,449 | +4,449 | 0.00 | 0.06 | +0.06 | buy |
| FEDERATED HERMES, INC. | 171,963 | 176,352 | +4,389 | 0.02 | 0.01 | -0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 61,862 | 65,907 | +4,045 | 0.14 | 0.09 | -0.05 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,741 | +2,741 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 2,985,190 | 2,987,845 | +2,655 | 4.38 | 3.38 | -1.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,699 | 10,062 | +2,363 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 24,501 | 26,594 | +2,093 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 57,688 | 59,546 | +1,858 | 0.00 | 0.00 | -0.00 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 1,074 | 2,901 | +1,827 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 15,874 | 17,675 | +1,801 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 1,766 | +1,766 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 12,570 | 14,298 | +1,728 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 0 | 1,574 | +1,574 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 34,606 | 36,129 | +1,523 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,879 | 6,294 | +1,415 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 8,006 | 9,311 | +1,305 | 0.02 | 0.01 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 58,519 | 59,517 | +998 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,431 | 3,423 | +992 | 0.05 | 0.04 | -0.01 | buy |
| Woodline Partners LP | 422,204 | 423,124 | +920 | 0.16 | 0.11 | -0.05 | buy |
| AMALGAMATED BANK | 1,715 | 2,223 | +508 | 0.00 | 0.00 | -0.00 | buy |
| Amundi | 193,341 | 193,665 | +324 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16,670 | 16,930 | +260 | 0.00 | 0.00 | -0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 0 | 199 | +199 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 124,979 | 125,161 | +182 | 0.63 | 0.45 | -0.18 | buy |
| CWM, LLC | 143 | 245 | +102 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 325,518 | 325,590 | +72 | 0.01 | 0.01 | -0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,535 | 1,587 | +52 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |