| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 4,017,788 | 5,467,063 | +1,449,275 | 2.63 | 3.66 | +1.03 | buy |
| ArrowMark Colorado Holdings LLC | 1,802,284 | 2,087,292 | +285,008 | 0.49 | 0.50 | +0.01 | buy |
| Finepoint Capital LP | 411,500 | 504,700 | +93,200 | 3.53 | 4.94 | +1.40 | buy |
| Woodline Partners LP | 112,600 | 172,600 | +60,000 | 0.03 | 0.04 | +0.01 | buy |
| ALGERT GLOBAL LLC | 119,189 | 173,418 | +54,229 | 0.13 | 0.16 | 0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 90,875 | 120,115 | +29,240 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 93,182 | 110,182 | +17,000 | 0.09 | 0.05 | 0.00 | buy |
| Corton Capital Inc. | 9,339 | 21,750 | +12,411 | 0.11 | 0.22 | +0.11 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 104,117 | +4,117 | 0.43 | 0.37 | -0.06 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 14,474 | 16,928 | +2,454 | 0.07 | 0.07 | -0.00 | buy |
| BIT Capital GmbH | 26,304 | 27,804 | +1,500 | 0.08 | 0.07 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 6,175 | 7,010 | +835 | 0.03 | 0.03 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 700 | 1,374 | +674 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 39,253 | 39,466 | +213 | 0.01 | 0.01 | -0.00 | buy |
| PDT Partners, LLC | 64,982 | 65,116 | +134 | 0.22 | 0.16 | -0.06 | buy |
| VIRTUS ADVISERS, LLC | 3,699 | 3,361 | -338 | 0.05 | 0.04 | -0.01 | sell |
| Bellevue Group AG | 2,127,000 | 2,125,200 | -1,800 | 0.75 | 0.67 | -0.08 | sell |
| Joel Isaacson & Co., LLC | 23,500 | 20,000 | -3,500 | 0.04 | 0.03 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,694,036 | 2,688,671 | -5,365 | 0.01 | 0.01 | -0.00 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 291,361 | 285,054 | -6,307 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 467,553 | 447,551 | -20,002 | 0.08 | 0.06 | -0.02 | sell |
| WASATCH ADVISORS LP | 271,060 | 206,709 | -64,351 | 0.04 | 0.03 | -0.02 | sell |
| Numerai GP LLC | 130,008 | 12,395 | -117,613 | 0.66 | 0.08 | -0.58 | sell |
| Aquilo Capital Management, LLC | 623,941 | 489,153 | -134,788 | 10.16 | 8.71 | -1.46 | sell |
| Avidity Partners Management LP | 2,773,189 | 2,614,960 | -158,229 | 2.40 | 2.07 | -0.34 | sell |
| GILDER GAGNON HOWE & CO LLC | 395,233 | 170,850 | -224,383 | 0.13 | 0.05 | -0.08 | sell |