| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 517,230 | 1,284,472 | +767,242 | 0.43 | 0.90 | +0.46 | buy |
| Opaleye Management Inc. | 555,000 | 1,255,000 | +700,000 | 3.38 | 5.16 | +1.78 | buy |
| WASATCH ADVISORS LP | 275,433 | 435,943 | +160,510 | 0.04 | 0.05 | +0.01 | buy |
| New Leaf Venture Partners, L.L.C. | 1,289,521 | 1,434,721 | +145,200 | 41.74 | 36.32 | -5.42 | buy |
| ALGERT GLOBAL LLC | 44,448 | 168,061 | +123,613 | 0.04 | 0.11 | 0.00 | buy |
| Woodline Partners LP | 423,124 | 497,737 | +74,613 | 0.11 | 0.10 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,639,499 | 2,707,551 | +68,052 | 0.10 | 0.10 | +0.01 | buy |
| BANQUE PICTET & CIE SA | 82,369 | 120,824 | +38,455 | 0.02 | 0.02 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 66,647 | 90,870 | +24,223 | 0.01 | 0.01 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 1,226,727 | 1,244,450 | +17,723 | 0.39 | 0.39 | +0.00 | buy |
| Aberdeen Group plc | 61,492 | 78,585 | +17,093 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 4,449 | 21,458 | +17,009 | 0.17 | 0.30 | +0.13 | buy |
| SECTORAL ASSET MANAGEMENT INC | 34,830 | 45,830 | +11,000 | 0.38 | 0.67 | +0.29 | buy |
| ZACKS INVESTMENT MANAGEMENT | 81,798 | 89,827 | +8,029 | 0.02 | 0.02 | -0.01 | buy |
| HighVista Strategies LLC | 51,122 | 58,001 | +6,879 | 0.50 | 0.49 | -0.00 | buy |
| Capula Management Ltd | 24,752 | 31,552 | +6,800 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,040 | 13,203 | +5,163 | 0.03 | 0.04 | +0.01 | buy |
| E. Ohman J:or Asset Management AB | 24,830 | 29,830 | +5,000 | 0.02 | 0.02 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 30,301 | 27,403 | +2,898 | 0.05 | 0.05 | 0.00 | sell |
| PROFUND ADVISORS LLC | 15,954 | 14,711 | +1,243 | 0.02 | 0.01 | 0.00 | sell |
| SHELL ASSET MANAGEMENT CO | 6,117 | 5,988 | +129 | 0.01 | 0.01 | 0.00 | sell |
| J.Safra Asset Management Corp | 12 | 80 | +68 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,423 | 3,486 | +63 | 0.04 | 0.04 | -0.00 | buy |
| ALPS ADVISORS INC | 53,365 | 53,421 | +56 | 0.01 | 0.01 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 65,907 | 64,125 | -1,782 | 0.09 | 0.07 | -0.02 | sell |
| NEOS Investment Management LLC | 20,032 | 16,750 | -3,282 | 0.02 | 0.01 | -0.01 | sell |
| Bellevue Group AG | 2,390,800 | 2,386,600 | -4,200 | 1.03 | 0.95 | -0.08 | sell |
| ADAR1 Capital Management, LLC | 32,400 | 20,400 | -12,000 | 0.17 | 0.08 | -0.09 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 236,174 | 223,690 | -12,484 | 0.01 | 0.01 | -0.00 | sell |
| BIT Capital GmbH | 80,972 | 67,281 | -13,691 | 0.17 | 0.15 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 125,161 | 96,183 | -28,978 | 0.45 | 0.30 | -0.14 | sell |
| Aquilo Capital Management, LLC | 428,766 | 388,766 | -40,000 | 11.00 | 10.78 | -0.23 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 212,354 | 147,190 | -65,164 | 0.12 | 0.08 | -0.04 | sell |
| Candriam S.C.A. | 610,458 | 524,781 | -85,677 | 0.10 | 0.07 | -0.02 | sell |
| GILDER GAGNON HOWE & CO LLC | 285,099 | 194,343 | -90,756 | 0.10 | 0.06 | -0.04 | sell |
| Paradigm Biocapital Advisors LP | 2,438,149 | 2,339,961 | -98,188 | 2.48 | 2.02 | -0.47 | sell |
| Rhenman & Partners Asset Management AB | 230,000 | 130,500 | -99,500 | 0.59 | 0.26 | -0.33 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,988,869 | 3,853,716 | -135,153 | 0.01 | 0.01 | -0.00 | sell |
| VR Adviser, LLC | 627,788 | 454,450 | -173,338 | 1.06 | 0.59 | -0.48 | sell |
| RTW INVESTMENTS, LP | 2,967,897 | 2,782,329 | -185,568 | 1.22 | 0.99 | -0.23 | sell |
| Commodore Capital LP | 1,884,361 | 1,200,000 | -684,361 | 3.42 | 1.85 | -1.58 | sell |
| Avidity Partners Management LP | 2,987,845 | 1,497,000 | -1,490,845 | 3.38 | 1.88 | -1.50 | sell |