| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 517,230 | 1,284,472 | +767,242 | 0.43 | 0.90 | +0.46 | buy |
| Opaleye Management Inc. | 555,000 | 1,255,000 | +700,000 | 3.38 | 5.16 | +1.78 | buy |
| BAKER BROS. ADVISORS LP | 0 | 405,576 | +405,576 | 0.00 | 0.10 | +0.10 | buy |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 1.10 | +1.10 | buy |
| JPMORGAN CHASE & CO | 1,961,960 | 2,329,303 | +367,343 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 6,671,821 | 7,006,000 | +334,179 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 142,375 | 444,053 | +301,678 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 1,078,246 | 1,323,433 | +245,187 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 228,800 | +228,800 | 0.00 | 0.47 | +0.47 | buy |
| Affinity Asset Advisors, LLC | 0 | 225,000 | +225,000 | 0.00 | 0.86 | +0.86 | buy |
| UBS Group AG | 256,359 | 471,578 | +215,219 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 178,326 | 386,269 | +207,943 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 2,679,287 | 2,883,604 | +204,317 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 463,935 | 657,176 | +193,241 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 41,700 | 227,600 | +185,900 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 275,433 | 435,943 | +160,510 | 0.04 | 0.05 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 594,425 | 754,126 | +159,701 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 20,200 | 170,350 | +150,150 | 0.00 | 0.01 | +0.00 | buy |
| New Leaf Venture Partners, L.L.C. | 1,289,521 | 1,434,721 | +145,200 | 41.74 | 36.32 | -5.42 | buy |
| Assenagon Asset Management S.A. | 0 | 139,741 | +139,741 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 44,448 | 168,061 | +123,613 | 0.04 | 0.11 | +0.07 | buy |
| Schonfeld Strategic Advisors LLC | 237,724 | 355,805 | +118,081 | 0.05 | 0.07 | +0.02 | buy |
| NORTHERN TRUST CORP | 495,845 | 588,493 | +92,648 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 40,715 | 121,699 | +80,984 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 423,124 | 497,737 | +74,613 | 0.11 | 0.10 | -0.00 | buy |
| CITADEL ADVISORS LLC | 2,639,499 | 2,707,551 | +68,052 | 0.07 | 0.07 | +0.00 | buy |
| Squarepoint Ops LLC | 118,899 | 169,848 | +50,949 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 186,407 | 230,386 | +43,979 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 43,445 | +43,445 | 0.00 | 0.01 | +0.01 | buy |
| BANQUE PICTET & CIE SA | 82,369 | 120,824 | +38,455 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 38,363 | +38,363 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 34,901 | +34,901 | 0.00 | 0.02 | +0.02 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 66,647 | 90,870 | +24,223 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,401 | +18,401 | 0.00 | 0.03 | +0.03 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 18,158 | +18,158 | 0.00 | 0.10 | +0.10 | buy |
| ArrowMark Colorado Holdings LLC | 1,226,727 | 1,244,450 | +17,723 | 0.39 | 0.39 | +0.00 | buy |
| Aberdeen Group plc | 61,492 | 78,585 | +17,093 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 4,449 | 21,458 | +17,009 | 0.06 | 0.30 | +0.25 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,226 | +14,226 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 12,645 | +12,645 | 0.00 | 0.02 | +0.02 | buy |
| Corton Capital Inc. | 0 | 11,691 | +11,691 | 0.00 | 0.14 | +0.14 | buy |
| SECTORAL ASSET MANAGEMENT INC | 34,830 | 45,830 | +11,000 | 0.38 | 0.67 | +0.29 | buy |
| DnB Asset Management AS | 0 | 10,365 | +10,365 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 10,149 | +10,149 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 17,675 | 27,137 | +9,462 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,032 | 35,161 | +9,129 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 8,809 | +8,809 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 8,443 | +8,443 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 200,199 | 208,625 | +8,426 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 129,248 | 137,295 | +8,047 | 0.00 | 0.01 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 81,798 | 89,827 | +8,029 | 0.02 | 0.02 | -0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,984 | +7,984 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 151,245 | 158,630 | +7,385 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 62,024 | 69,190 | +7,166 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 51,122 | 58,001 | +6,879 | 0.50 | 0.49 | -0.00 | buy |
| Capula Management Ltd | 24,752 | 31,552 | +6,800 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 26,459 | 32,789 | +6,330 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,848 | 10,691 | +5,843 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,980 | 16,196 | +5,216 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,040 | 13,203 | +5,163 | 0.03 | 0.04 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 256,658 | 261,711 | +5,053 | 0.03 | 0.03 | -0.00 | buy |
| E. Ohman J:or Asset Management AB | 24,830 | 29,830 | +5,000 | 0.02 | 0.02 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,201 | +3,201 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 16,625 | 19,525 | +2,900 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,713 | 8,564 | +2,851 | 0.00 | 0.01 | +0.00 | buy |
| Quantbot Technologies LP | 1,766 | 4,367 | +2,601 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 16,837 | 19,345 | +2,508 | 0.05 | 0.05 | +0.01 | buy |
| HSBC HOLDINGS PLC | 13,238 | 15,669 | +2,431 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 94,658 | 97,008 | +2,350 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 25,157 | 27,245 | +2,088 | 0.01 | 0.01 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 4,861 | 6,659 | +1,798 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 14,807 | 16,592 | +1,785 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,741 | 4,443 | +1,702 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 1,600 | +1,600 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 10,533 | 12,015 | +1,482 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 31,762 | 32,570 | +808 | 0.02 | 0.02 | -0.00 | buy |
| Atlantic Private Wealth, LLC | 0 | 577 | +577 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 36,129 | 36,673 | +544 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 6,913 | 7,416 | +503 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,043 | 2,483 | +440 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,386 | 13,793 | +407 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 52 | 339 | +287 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 24,770 | 24,920 | +150 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 16 | 110 | +94 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,587 | 1,662 | +75 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 12 | 80 | +68 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,423 | 3,486 | +63 | 0.04 | 0.04 | -0.00 | buy |
| ALPS ADVISORS INC | 53,365 | 53,421 | +56 | 0.01 | 0.01 | -0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 199 | 240 | +41 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 50 | +35 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 294 | 314 | +20 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CAROLINAS WEALTH CONSULTING LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 14,524 | 14,524 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,294 | 6,294 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 73,720 | 73,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 28,422 | 28,422 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 1,027,749 | 1,027,749 | 0 | 0.66 | 0.54 | -0.12 | hold |
| TANG CAPITAL MANAGEMENT LLC | 180,000 | 180,000 | 0 | 0.49 | 0.32 | -0.17 | hold |