| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 6,671,821 | 7,006,000 | +334,179 | 0.00 | 0.00 | -0.00 | buy |
| EcoR1 Capital, LLC | 6,726,491 | 6,726,491 | 0 | 5.48 | 5.67 | +0.20 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,988,869 | 3,853,716 | -135,153 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 2,679,287 | 2,883,604 | +204,317 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 2,967,897 | 2,782,329 | -185,568 | 1.22 | 0.99 | -0.23 | sell |
| CITADEL ADVISORS LLC | 2,639,499 | 2,707,551 | +68,052 | 0.07 | 0.07 | +0.00 | buy |
| Bellevue Group AG | 2,390,800 | 2,386,600 | -4,200 | 1.03 | 0.95 | -0.08 | sell |
| Paradigm Biocapital Advisors LP | 2,438,149 | 2,339,961 | -98,188 | 2.48 | 2.02 | -0.47 | sell |
| JPMORGAN CHASE & CO | 1,961,960 | 2,329,303 | +367,343 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,699,688 | 1,643,727 | -55,961 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,541,737 | 1,519,334 | -22,403 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 2,987,845 | 1,497,000 | -1,490,845 | 3.38 | 1.88 | -1.50 | sell |
| New Leaf Venture Partners, L.L.C. | 1,289,521 | 1,434,721 | +145,200 | 41.74 | 36.32 | -5.42 | buy |
| NORGES BANK | 1,078,246 | 1,323,433 | +245,187 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 517,230 | 1,284,472 | +767,242 | 0.43 | 0.90 | +0.46 | buy |
| Opaleye Management Inc. | 555,000 | 1,255,000 | +700,000 | 3.38 | 5.16 | +1.78 | buy |
| ArrowMark Colorado Holdings LLC | 1,226,727 | 1,244,450 | +17,723 | 0.39 | 0.39 | +0.00 | buy |
| Commodore Capital LP | 1,884,361 | 1,200,000 | -684,361 | 3.42 | 1.85 | -1.58 | sell |
| PERCEPTIVE ADVISORS LLC | 1,027,749 | 1,027,749 | 0 | 0.66 | 0.54 | -0.12 | hold |
| GOLDMAN SACHS GROUP INC | 594,425 | 754,126 | +159,701 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 463,935 | 657,176 | +193,241 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 495,845 | 588,493 | +92,648 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 574,378 | 574,378 | 0 | 4.34 | 1.72 | -2.62 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 544,503 | 530,669 | -13,834 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 610,458 | 524,781 | -85,677 | 0.10 | 0.07 | -0.02 | sell |
| MORGAN STANLEY | 779,791 | 522,593 | -257,198 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 423,124 | 497,737 | +74,613 | 0.11 | 0.10 | -0.00 | buy |
| UBS Group AG | 256,359 | 471,578 | +215,219 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 627,788 | 454,450 | -173,338 | 1.06 | 0.59 | -0.48 | sell |
| BANK OF AMERICA CORP /DE/ | 142,375 | 444,053 | +301,678 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 275,433 | 435,943 | +160,510 | 0.04 | 0.05 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 431,176 | 430,484 | -692 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 421,348 | 421,348 | 0 | 0.15 | 0.12 | -0.03 | hold |
| BAKER BROS. ADVISORS LP | 0 | 405,576 | +405,576 | 0.00 | 0.10 | +0.10 | buy |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 1.10 | +1.10 | buy |
| Aquilo Capital Management, LLC | 428,766 | 388,766 | -40,000 | 11.00 | 10.78 | -0.23 | sell |
| TWO SIGMA INVESTMENTS, LP | 178,326 | 386,269 | +207,943 | 0.01 | 0.02 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 237,724 | 355,805 | +118,081 | 0.05 | 0.07 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 325,590 | 311,473 | -14,117 | 0.01 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 285,331 | 285,331 | 0 | 0.36 | 0.28 | -0.07 | hold |
| PANAGORA ASSET MANAGEMENT INC | 256,658 | 261,711 | +5,053 | 0.03 | 0.03 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 186,407 | 230,386 | +43,979 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 228,800 | +228,800 | 0.00 | 0.47 | +0.47 | buy |
| TWO SIGMA ADVISERS, LP | 41,700 | 227,600 | +185,900 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 225,000 | +225,000 | 0.00 | 0.86 | +0.86 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 236,174 | 223,690 | -12,484 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 299,745 | 209,909 | -89,836 | 0.01 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 200,199 | 208,625 | +8,426 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 285,099 | 194,343 | -90,756 | 0.10 | 0.06 | -0.04 | sell |
| Bank of New York Mellon Corp | 235,096 | 189,804 | -45,292 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 180,000 | 180,000 | 0 | 0.49 | 0.32 | -0.17 | hold |
| MARSHALL WACE, LLP | 20,200 | 170,350 | +150,150 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 118,899 | 169,848 | +50,949 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 44,448 | 168,061 | +123,613 | 0.04 | 0.11 | +0.07 | buy |
| Neuberger Berman Group LLC | 151,245 | 158,630 | +7,385 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 212,354 | 147,190 | -65,164 | 0.12 | 0.08 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 275,400 | 144,400 | -131,000 | 0.01 | 0.01 | -0.01 | sell |
| Assenagon Asset Management S.A. | 0 | 139,741 | +139,741 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 129,248 | 137,295 | +8,047 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 176,352 | 134,210 | -42,142 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 230,000 | 130,500 | -99,500 | 0.59 | 0.26 | -0.33 | sell |
| BARCLAYS PLC | 40,715 | 121,699 | +80,984 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 82,369 | 120,824 | +38,455 | 0.02 | 0.03 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 94,658 | 97,008 | +2,350 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 125,161 | 96,183 | -28,978 | 0.45 | 0.30 | -0.15 | sell |
| Swiss National Bank | 94,000 | 94,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 66,647 | 90,870 | +24,223 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 95,105 | 90,406 | -4,699 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 81,798 | 89,827 | +8,029 | 0.02 | 0.02 | -0.01 | buy |
| RHUMBLINE ADVISERS | 90,229 | 87,123 | -3,106 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 61,492 | 78,585 | +17,093 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 73,720 | 73,720 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 91,548 | 73,548 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 62,024 | 69,190 | +7,166 | 0.00 | 0.00 | -0.00 | buy |
| BIT Capital GmbH | 80,972 | 67,281 | -13,691 | 0.20 | 0.16 | -0.04 | sell |
| Hennion & Walsh Asset Management, Inc. | 65,907 | 64,125 | -1,782 | 0.09 | 0.07 | -0.02 | sell |
| Graham Capital Management, L.P. | 64,106 | 63,576 | -530 | 0.06 | 0.05 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 82,058 | 60,399 | -21,659 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 59,517 | 58,990 | -527 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 73,382 | 58,264 | -15,118 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 51,122 | 58,001 | +6,879 | 0.50 | 0.49 | -0.00 | buy |
| Legal & General Group Plc | 59,546 | 57,599 | -1,947 | 0.00 | 0.00 | -0.00 | sell |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 57,500 | 57,500 | 0 | 0.60 | 0.60 | +0.00 | hold |
| ALPS ADVISORS INC | 53,365 | 53,421 | +56 | 0.01 | 0.01 | -0.00 | buy |
| Yelin Lapidot Holdings Management Ltd. | 49,503 | 49,503 | 0 | 0.23 | 0.20 | -0.03 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 53,912 | 46,520 | -7,392 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,907 | 46,516 | -1,391 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 34,830 | 45,830 | +11,000 | 0.38 | 0.67 | +0.29 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,842 | 45,042 | -24,800 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 43,445 | +43,445 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 42,000 | 42,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Verition Fund Management LLC | 91,351 | 38,631 | -52,720 | 0.02 | 0.01 | -0.01 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 38,363 | +38,363 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 84,692 | 37,349 | -47,343 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 37,180 | 37,180 | 0 | 0.01 | 0.01 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 224,351 | 37,124 | -187,227 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 36,129 | 36,673 | +544 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,032 | 35,161 | +9,129 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 34,901 | +34,901 | 0.00 | 0.02 | +0.02 | buy |
| Corebridge Financial, Inc. | 34,562 | 34,351 | -211 | 0.01 | 0.00 | -0.00 | sell |