| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9,393,161 | 8,561,232 | -831,929 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 6,889,452 | 6,802,938 | -86,514 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 3,300,000 | 5,575,000 | +2,275,000 | 3.24 | 4.69 | +1.45 | buy |
| PFIZER INC | 3,457,815 | 3,457,815 | 0 | 4.42 | 6.73 | +2.32 | hold |
| D. E. Shaw & Co., Inc. | 2,150,730 | 3,347,163 | +1,196,433 | 0.02 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,898,072 | 2,131,555 | +233,483 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,732,323 | 1,873,086 | +140,763 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,585,092 | 1,670,179 | +85,087 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,583,729 | 1,662,221 | +78,492 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 1,617,365 | +1,617,365 | 0.00 | 0.68 | +0.68 | buy |
| New Leaf Venture Partners, L.L.C. | 1,585,721 | 1,585,721 | 0 | 22.04 | 31.38 | +9.34 | hold |
| Qube Research & Technologies Ltd | 583,527 | 1,486,864 | +903,337 | 0.01 | 0.02 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,427,832 | 1,464,413 | +36,581 | 0.02 | 0.02 | +0.00 | buy |
| Nextech Invest, Ltd. | 1,408,394 | 1,408,394 | 0 | 1.96 | 1.83 | -0.14 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,393,800 | 1,393,800 | 0 | 0.52 | 0.46 | -0.06 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 212,142 | 1,207,267 | +995,125 | 0.00 | 0.02 | +0.02 | buy |
| ARMISTICE CAPITAL, LLC | 560,000 | 1,200,000 | +640,000 | 0.16 | 0.32 | +0.16 | buy |
| Opaleye Management Inc. | 1,680,000 | 987,818 | -692,182 | 2.50 | 1.19 | -1.31 | sell |
| GOLDMAN SACHS GROUP INC | 825,688 | 736,563 | -89,125 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 900,936 | 710,936 | -190,000 | 2.51 | 2.26 | -0.26 | sell |
| Avidity Partners Management LP | 243,162 | 698,363 | +455,201 | 0.36 | 1.35 | +1.00 | buy |
| Rangeley Capital, LLC | 694,800 | 695,400 | +600 | 6.42 | 5.56 | -0.85 | buy |
| FEDERATED HERMES, INC. | 686,912 | 680,885 | -6,027 | 0.01 | 0.01 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,214,355 | 669,655 | -544,700 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 668,118 | 665,752 | -2,366 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 529,418 | 609,773 | +80,355 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON ASSOCIATES LLP | 298,062 | 604,785 | +306,723 | 0.06 | 0.14 | +0.08 | buy |
| NORTHERN TRUST CORP | 560,553 | 599,219 | +38,666 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 885,843 | 561,431 | -324,412 | 0.05 | 0.03 | -0.02 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 433,488 | 557,742 | +124,254 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 452,424 | 506,867 | +54,443 | 0.02 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 463,348 | +463,348 | 0.00 | 0.00 | +0.00 | buy |
| Arbiter Partners Capital Management LLC | 0 | 452,789 | +452,789 | 0.00 | 2.64 | +2.64 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 382,365 | 442,703 | +60,338 | 0.07 | 0.08 | +0.02 | buy |
| UBS Group AG | 1,021,653 | 400,136 | -621,517 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 142,950 | 396,868 | +253,918 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 145,745 | 283,539 | +137,794 | 0.03 | 0.06 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 273,695 | +273,695 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 260,818 | 257,775 | -3,043 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 424,795 | 254,401 | -170,394 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 892,941 | 243,326 | -649,615 | 0.14 | 0.03 | -0.10 | sell |
| ExodusPoint Capital Management, LP | 0 | 241,498 | +241,498 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 162,928 | 238,056 | +75,128 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 166,679 | 237,903 | +71,224 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 850,000 | 226,257 | -623,743 | 2.07 | 0.39 | -1.68 | sell |
| AQR CAPITAL MANAGEMENT LLC | 614,457 | 223,822 | -390,635 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 54,832 | 223,576 | +168,744 | 0.03 | 0.14 | +0.12 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 176,242 | 222,480 | +46,238 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 37,319 | 214,779 | +177,460 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 199,925 | 205,687 | +5,762 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 222,397 | 192,544 | -29,853 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 4,050 | 187,643 | +183,593 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 406,384 | 187,570 | -218,814 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 63,131 | 182,159 | +119,028 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 180,000 | 180,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 220,833 | 169,969 | -50,864 | 0.00 | 0.00 | -0.00 | sell |
| ZACKS INVESTMENT MANAGEMENT | 90,859 | 158,080 | +67,221 | 0.01 | 0.01 | +0.01 | buy |
| Voleon Capital Management LP | 0 | 152,056 | +152,056 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 3,674,314 | 151,465 | -3,522,849 | 0.02 | 0.00 | -0.02 | sell |
| Nuveen, LLC | 142,782 | 142,782 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 135,233 | +135,233 | 0.00 | 0.02 | +0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 130,000 | 130,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| XTX Topco Ltd | 67,389 | 128,548 | +61,159 | 0.02 | 0.06 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 182,611 | 125,112 | -57,499 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 92,895 | 119,744 | +26,849 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 94,000 | 113,200 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 16,705 | 111,008 | +94,303 | 0.04 | 0.31 | +0.27 | buy |
| RHUMBLINE ADVISERS | 102,077 | 99,374 | -2,703 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 98,263 | +98,263 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 234,628 | 87,409 | -147,219 | 0.05 | 0.03 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,333,972 | 87,316 | -1,246,656 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 86,930 | +86,930 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 80,879 | 83,666 | +2,787 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 128,767 | 82,591 | -46,176 | 0.15 | 0.07 | -0.08 | sell |
| Verition Fund Management LLC | 37,633 | 79,951 | +42,318 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 73,720 | 73,720 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Numerai GP LLC | 0 | 67,919 | +67,919 | 0.00 | 0.08 | +0.08 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 154,089 | 66,343 | -87,746 | 0.91 | 0.42 | -0.49 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 283,425 | 64,914 | -218,511 | 0.06 | 0.01 | -0.05 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 86,964 | 63,773 | -23,191 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 65,624 | 62,107 | -3,517 | 0.00 | 0.00 | -0.00 | sell |
| Quinn Opportunity Partners LLC | 71,263 | 61,263 | -10,000 | 0.05 | 0.04 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,111 | 61,182 | +15,071 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 59,174 | +59,174 | 0.00 | 0.08 | +0.08 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 57,500 | 57,500 | 0 | 0.27 | 0.29 | +0.02 | hold |
| GROUP ONE TRADING LLC | 215,079 | 55,030 | -160,049 | 0.05 | 0.01 | -0.04 | sell |
| Quadrature Capital Ltd | 35,746 | 53,499 | +17,753 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 51,806 | 51,806 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantinno Capital Management LP | 30,605 | 51,776 | +21,171 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 60,966 | 51,383 | -9,583 | 0.02 | 0.02 | -0.00 | sell |
| Man Group plc | 53,748 | 51,341 | -2,407 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.39 | +0.39 | buy |
| Yelin Lapidot Holdings Management Ltd. | 46,665 | 46,665 | 0 | 0.06 | 0.08 | +0.02 | hold |
| Creative Planning | 30,773 | 44,835 | +14,062 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 42,921 | 42,500 | -421 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 42,000 | 42,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 153,074 | 41,918 | -111,156 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 0 | 39,687 | +39,687 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 50,366 | 39,395 | -10,971 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 108,800 | 38,530 | -70,270 | 0.02 | 0.01 | -0.01 | sell |