| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 5,467,063 | 6,726,491 | +1,259,428 | 3.62 | 7.19 | +3.57 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,688,671 | 3,832,123 | +1,143,452 | 0.01 | 0.02 | +0.01 | buy |
| Bellevue Group AG | 2,125,200 | 2,507,731 | +382,531 | 0.67 | 1.58 | +0.91 | buy |
| Avidity Partners Management LP | 2,614,960 | 2,985,117 | +370,157 | 2.07 | 4.70 | +2.63 | buy |
| Woodline Partners LP | 172,600 | 387,630 | +215,030 | 0.04 | 0.17 | +0.13 | buy |
| GILDER GAGNON HOWE & CO LLC | 170,850 | 333,524 | +162,674 | 0.05 | 0.19 | +0.14 | buy |
| BIT Capital GmbH | 27,804 | 135,722 | +107,918 | 0.06 | 0.55 | +0.49 | buy |
| ALGERT GLOBAL LLC | 173,418 | 74,571 | +98,847 | 0.16 | 0.12 | 0.00 | sell |
| Parkman Healthcare Partners LLC | 104,117 | 167,001 | +62,884 | 0.37 | 0.97 | +0.60 | buy |
| SECTORAL ASSET MANAGEMENT INC | 7,010 | 66,000 | +58,990 | 0.03 | 1.17 | +1.14 | buy |
| TD ASSET MANAGEMENT INC | 94,872 | 146,948 | +52,076 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 85,000 | 134,270 | +49,270 | 0.18 | 0.55 | +0.37 | buy |
| Candriam S.C.A. | 447,551 | 487,555 | +40,004 | 0.06 | 0.14 | +0.08 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 110,182 | 91,132 | +19,050 | 0.05 | 0.27 | 0.00 | sell |
| WASATCH ADVISORS LP | 206,709 | 222,942 | +16,233 | 0.03 | 0.05 | +0.02 | buy |
| Corton Capital Inc. | 21,750 | 27,199 | +5,449 | 0.22 | 0.36 | +0.14 | buy |
| China Universal Asset Management Co., Ltd. | 1,374 | 6,370 | +4,996 | 0.01 | 0.05 | +0.04 | buy |
| Headlands Technologies LLC | 484 | 2,388 | +1,904 | 0.00 | 0.03 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 16,928 | 18,167 | +1,239 | 0.07 | 0.14 | +0.07 | buy |
| MACROVIEW INVESTMENT MANAGEMENT LLC | 331 | 119 | -212 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,361 | 2,595 | -766 | 0.04 | 0.07 | +0.03 | sell |
| ALPS ADVISORS INC | 39,466 | 35,397 | -4,069 | 0.01 | 0.01 | +0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 285,054 | 278,737 | -6,317 | 0.01 | 0.01 | +0.01 | sell |
| Joel Isaacson & Co., LLC | 20,000 | 11,000 | -9,000 | 0.03 | 0.03 | +0.00 | sell |
| PDT Partners, LLC | 65,116 | 38,087 | -27,029 | 0.16 | 0.17 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 120,115 | 46,761 | -73,354 | 0.01 | 0.01 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 2,087,292 | 1,569,895 | -517,397 | 0.50 | 0.71 | +0.21 | sell |