| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 4,213,483 | +4,213,483 | 0.00 | 2.71 | +2.71 | buy |
| CITADEL ADVISORS LLC | 624,578 | 2,439,981 | +1,815,403 | 0.01 | 0.10 | +0.09 | buy |
| EcoR1 Capital, LLC | 5,467,063 | 6,726,491 | +1,259,428 | 3.66 | 7.19 | +3.53 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,688,671 | 3,832,123 | +1,143,452 | 0.01 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 3.60 | +3.60 | buy |
| Paradigm Biocapital Advisors LP | 0 | 931,303 | +931,303 | 0.00 | 1.80 | +1.80 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 789,485 | +789,485 | 0.00 | 0.07 | +0.07 | buy |
| Holocene Advisors, LP | 0 | 744,465 | +744,465 | 0.00 | 0.12 | +0.12 | buy |
| VR Adviser, LLC | 0 | 627,788 | +627,788 | 0.00 | 1.77 | +1.77 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 421,348 | +421,348 | 0.00 | 0.27 | +0.27 | buy |
| Bellevue Group AG | 2,125,200 | 2,507,731 | +382,531 | 0.67 | 1.58 | +0.91 | buy |
| NORGES BANK | 505,462 | 877,708 | +372,246 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 2,614,960 | 2,985,117 | +370,157 | 2.07 | 4.70 | +2.63 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 354,082 | +354,082 | 0.00 | 0.33 | +0.33 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 309,663 | +309,663 | 0.00 | 0.05 | +0.05 | buy |
| MORGAN STANLEY | 404,322 | 693,479 | +289,157 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 263,700 | +263,700 | 0.00 | 2.89 | +2.89 | buy |
| VANGUARD GROUP INC | 4,608,223 | 4,851,390 | +243,167 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 234,082 | +234,082 | 0.00 | 1.64 | +1.64 | buy |
| Woodline Partners LP | 172,600 | 387,630 | +215,030 | 0.04 | 0.17 | +0.13 | buy |
| JPMORGAN CHASE & CO | 1,989,247 | 2,172,829 | +183,582 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 63,994 | 245,868 | +181,874 | 0.01 | 0.08 | +0.07 | buy |
| Integral Health Asset Management, LLC | 0 | 175,000 | +175,000 | 0.00 | 1.04 | +1.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 170,850 | 333,524 | +162,674 | 0.05 | 0.19 | +0.14 | buy |
| YALE UNIVERSITY | 0 | 143,522 | +143,522 | 0.00 | 5.23 | +5.23 | buy |
| GOLDMAN SACHS GROUP INC | 194,650 | 329,459 | +134,809 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,690 | 138,656 | +133,966 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 45,602 | 172,437 | +126,835 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 113,700 | 237,573 | +123,873 | 0.00 | 0.02 | +0.01 | buy |
| BIT Capital GmbH | 27,804 | 135,722 | +107,918 | 0.07 | 0.60 | +0.53 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 99,391 | 197,052 | +97,661 | 0.00 | 0.01 | +0.01 | buy |
| BANQUE PICTET & CIE SA | 0 | 92,933 | +92,933 | 0.00 | 0.04 | +0.04 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 74,000 | +74,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 160,706 | 232,617 | +71,911 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 71,695 | +71,695 | 0.00 | 0.04 | +0.04 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 71,570 | +71,570 | 0.00 | 0.13 | +0.13 | buy |
| Vontobel Holding Ltd. | 0 | 66,000 | +66,000 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,057,390 | 1,122,627 | +65,237 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 20,800 | 84,931 | +64,131 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 104,117 | 167,001 | +62,884 | 0.37 | 0.97 | +0.60 | buy |
| Trexquant Investment LP | 0 | 61,243 | +61,243 | 0.00 | 0.06 | +0.06 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 60,873 | +60,873 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 7,010 | 66,000 | +58,990 | 0.03 | 1.17 | +1.14 | buy |
| Jefferies Financial Group Inc. | 0 | 58,790 | +58,790 | 0.00 | 0.04 | +0.04 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 53,508 | +53,508 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 94,872 | 146,948 | +52,076 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 33,797 | 83,621 | +49,824 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 85,000 | 134,270 | +49,270 | 0.18 | 0.55 | +0.37 | buy |
| MARSHALL WACE, LLP | 0 | 47,066 | +47,066 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 50,323 | 97,217 | +46,894 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 108,489 | 155,036 | +46,547 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 447,551 | 487,555 | +40,004 | 0.06 | 0.14 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 429,990 | 469,474 | +39,484 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 36,084 | +36,084 | 0.00 | 0.08 | +0.08 | buy |
| FEDERATED HERMES, INC. | 104,258 | 138,028 | +33,770 | 0.01 | 0.01 | +0.01 | buy |
| Altium Capital Management LLC | 0 | 31,210 | +31,210 | 0.00 | 0.89 | +0.89 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 27,889 | +27,889 | 0.00 | 0.00 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 0 | 27,500 | +27,500 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 1,159,452 | 1,186,474 | +27,022 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 469,398 | 491,877 | +22,479 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 63,715 | 85,996 | +22,281 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 20,000 | 42,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,317 | 89,228 | +21,911 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 21,607 | +21,607 | 0.00 | 0.03 | +0.03 | buy |
| FORA Capital, LLC | 0 | 21,228 | +21,228 | 0.00 | 0.08 | +0.08 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 18,407 | +18,407 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,273 | +18,273 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,028 | +17,028 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 206,709 | 222,942 | +16,233 | 0.03 | 0.05 | +0.02 | buy |
| Bank Julius Baer & Co. Ltd, Zurich | 0 | 16,000 | +16,000 | 0.00 | 0.01 | +0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 15,844 | +15,844 | 0.00 | 0.09 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 0 | 15,211 | +15,211 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 58,785 | 73,975 | +15,190 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 477,597 | 491,235 | +13,638 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 13,274 | +13,274 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 11,725 | +11,725 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,644 | +11,644 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 11,015 | +11,015 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,759 | +10,759 | 0.00 | 0.11 | +0.11 | buy |
| Qube Research & Technologies Ltd | 0 | 10,198 | +10,198 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 177,244 | 187,303 | +10,059 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 9,787 | +9,787 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,110 | 16,538 | +9,428 | 0.00 | 0.00 | +0.00 | buy |
| Oliver Luxxe Assets LLC | 0 | 7,742 | +7,742 | 0.00 | 0.07 | +0.07 | buy |
| SEI INVESTMENTS CO | 0 | 7,670 | +7,670 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,313 | 26,625 | +7,312 | 0.00 | 0.00 | +0.00 | buy |
| Bank Pictet & Cie (Europe) AG | 0 | 7,073 | +7,073 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,113 | 51,096 | +6,983 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 6,864 | +6,864 | 0.00 | 0.03 | +0.03 | buy |
| Petrus Trust Company, LTA | 0 | 6,823 | +6,823 | 0.00 | 0.03 | +0.03 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 6,733 | +6,733 | 0.00 | 0.01 | +0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 6,727 | +6,727 | 0.00 | 0.05 | +0.05 | buy |
| Allianz Asset Management GmbH | 0 | 6,700 | +6,700 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 6,474 | +6,474 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 6,423 | +6,423 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 6,419 | +6,419 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 6,406 | +6,406 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 21,750 | 27,199 | +5,449 | 0.22 | 0.36 | +0.14 | buy |
| LEVEL FOUR ADVISORY SERVICES, LLC | 0 | 5,400 | +5,400 | 0.00 | 0.01 | +0.01 | buy |