| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,782,329 | 3,334,308 | +551,979 | 0.99 | 0.97 | -0.02 | buy |
| ArrowMark Colorado Holdings LLC | 1,244,450 | 1,776,555 | +532,105 | 0.39 | 0.46 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 225,000 | 630,000 | +405,000 | 0.76 | 1.62 | +0.86 | buy |
| Opaleye Management Inc. | 1,255,000 | 1,625,000 | +370,000 | 5.16 | 5.89 | +0.73 | buy |
| Logos Global Management LP | 400,000 | 700,000 | +300,000 | 1.06 | 1.57 | +0.51 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,853,716 | 4,103,011 | +249,295 | 0.01 | 0.01 | -0.00 | buy |
| BIT Capital GmbH | 67,281 | 263,527 | +196,246 | 0.15 | 0.40 | +0.25 | buy |
| Woodline Partners LP | 497,737 | 692,733 | +194,996 | 0.10 | 0.09 | -0.01 | buy |
| New Leaf Venture Partners, L.L.C. | 1,434,721 | 1,585,721 | +151,000 | 36.32 | 40.64 | +4.32 | buy |
| Finepoint Capital LP | 574,378 | 713,778 | +139,400 | 1.03 | 0.84 | -0.19 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 147,190 | 208,992 | +61,802 | 0.08 | 0.09 | +0.01 | buy |
| ALGERT GLOBAL LLC | 168,061 | 205,988 | +37,927 | 0.11 | 0.09 | 0.00 | buy |
| Rhenman & Partners Asset Management AB | 130,500 | 155,500 | +25,000 | 0.26 | 0.31 | +0.05 | buy |
| SIT INVESTMENT ASSOCIATES INC | 34,901 | 51,594 | +16,693 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 386,269 | 397,502 | +11,233 | 0.02 | 0.02 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 96,183 | 106,871 | +10,688 | 0.30 | 0.27 | -0.03 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 223,690 | 232,886 | +9,196 | 0.01 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 12,645 | 19,249 | +6,604 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 2,386,600 | 2,389,600 | +3,000 | 0.95 | 0.88 | -0.07 | buy |
| PROFUND ADVISORS LLC | 14,711 | 12,052 | +2,659 | 0.01 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,203 | 14,570 | +1,367 | 0.04 | 0.03 | -0.01 | buy |
| WASATCH ADVISORS LP | 435,943 | 436,241 | +298 | 0.05 | 0.04 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 3,486 | 3,601 | +115 | 0.04 | 0.03 | -0.01 | buy |
| DnB Asset Management AS | 10,365 | 10,234 | -131 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 64,125 | 63,477 | -648 | 0.07 | 0.06 | -0.02 | sell |
| Yelin Lapidot Holdings Management Ltd. | 49,503 | 46,873 | -2,630 | 0.20 | 0.16 | -0.04 | sell |
| ZACKS INVESTMENT MANAGEMENT | 89,827 | 86,448 | -3,379 | 0.02 | 0.02 | -0.00 | sell |
| NEOS Investment Management LLC | 16,750 | 11,835 | -4,915 | 0.01 | 0.01 | -0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 194,343 | 186,594 | -7,749 | 0.06 | 0.04 | -0.02 | sell |
| BANQUE PICTET & CIE SA | 120,824 | 110,619 | -10,205 | 0.02 | 0.01 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 45,830 | 30,150 | -15,680 | 0.67 | 0.39 | -0.28 | sell |
| Capula Management Ltd | 31,552 | 10,758 | -20,794 | 0.01 | 0.00 | -0.01 | sell |
| Aquilo Capital Management, LLC | 388,766 | 328,766 | -60,000 | 10.78 | 10.79 | +0.02 | sell |
| Candriam S.C.A. | 610,458 | 503,936 | -106,522 | 0.10 | 0.06 | -0.04 | sell |
| Avidity Partners Management LP | 1,497,000 | 1,358,000 | -139,000 | 1.88 | 2.56 | +0.68 | sell |
| PERCEPTIVE ADVISORS LLC | 1,027,749 | 740,749 | -287,000 | 0.54 | 0.39 | -0.14 | sell |