| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 2,208,234 | +2,208,234 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 471,578 | 2,038,459 | +1,566,881 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 2,782,329 | 3,334,308 | +551,979 | 0.99 | 0.97 | -0.02 | buy |
| ArrowMark Colorado Holdings LLC | 1,244,450 | 1,776,555 | +532,105 | 0.39 | 0.46 | +0.07 | buy |
| MORGAN STANLEY | 522,593 | 1,000,181 | +477,588 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 225,000 | 630,000 | +405,000 | 0.86 | 1.89 | +1.03 | buy |
| Opaleye Management Inc. | 1,255,000 | 1,625,000 | +370,000 | 5.16 | 5.89 | +0.73 | buy |
| CITADEL ADVISORS LLC | 2,707,551 | 3,072,668 | +365,117 | 0.07 | 0.05 | -0.02 | buy |
| Schonfeld Strategic Advisors LLC | 355,805 | 656,100 | +300,295 | 0.07 | 0.08 | +0.01 | buy |
| Logos Global Management LP | 400,000 | 700,000 | +300,000 | 1.10 | 1.57 | +0.47 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,853,716 | 4,103,011 | +249,295 | 0.01 | 0.01 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 218,700 | +218,700 | 0.00 | 3.15 | +3.15 | buy |
| Caption Management, LLC | 0 | 206,915 | +206,915 | 0.00 | 0.16 | +0.16 | buy |
| BIT Capital GmbH | 67,281 | 263,527 | +196,246 | 0.16 | 0.44 | +0.28 | buy |
| Woodline Partners LP | 497,737 | 692,733 | +194,996 | 0.10 | 0.09 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 657,176 | 843,430 | +186,254 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 164,112 | +164,112 | 0.00 | 0.05 | +0.05 | buy |
| New Leaf Venture Partners, L.L.C. | 1,434,721 | 1,585,721 | +151,000 | 36.32 | 40.64 | +4.32 | buy |
| Finepoint Capital LP | 574,378 | 713,778 | +139,400 | 1.72 | 1.58 | -0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 208,625 | 314,843 | +106,218 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 170,350 | 268,026 | +97,676 | 0.01 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 0 | 86,627 | +86,627 | 0.00 | 0.62 | +0.62 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 0 | 80,000 | +80,000 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 6,496,086 | 6,566,145 | +70,059 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 65,400 | +65,400 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 65,209 | +65,209 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 147,190 | 208,992 | +61,802 | 0.08 | 0.09 | +0.01 | buy |
| VANGUARD GROUP INC | 7,006,000 | 7,062,561 | +56,561 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 227,600 | 282,600 | +55,000 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 121,699 | 175,019 | +53,320 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 73,548 | 122,348 | +48,800 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 29,732 | 74,651 | +44,919 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 588,493 | 631,131 | +42,638 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 39,063 | +39,063 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,984 | 46,907 | +38,923 | 0.01 | 0.03 | +0.02 | buy |
| ALGERT GLOBAL LLC | 168,061 | 205,988 | +37,927 | 0.11 | 0.09 | -0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 261,711 | 297,186 | +35,475 | 0.03 | 0.03 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 23,769 | 58,052 | +34,283 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 130,500 | 155,500 | +25,000 | 0.26 | 0.31 | +0.05 | buy |
| Monaco Asset Management SAM | 0 | 25,000 | +25,000 | 0.00 | 0.21 | +0.21 | buy |
| Graham Capital Management, L.P. | 63,576 | 87,879 | +24,303 | 0.05 | 0.05 | +0.00 | buy |
| SG Americas Securities, LLC | 9,860 | 32,424 | +22,564 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 38,631 | 60,529 | +21,898 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 97,008 | 116,513 | +19,505 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 17,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 34,901 | 51,594 | +16,693 | 0.02 | 0.02 | +0.00 | buy |
| Centiva Capital, LP | 0 | 12,989 | +12,989 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 386,269 | 397,502 | +11,233 | 0.02 | 0.02 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 96,183 | 106,871 | +10,688 | 0.30 | 0.27 | -0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,226 | 24,152 | +9,926 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 223,690 | 232,886 | +9,196 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 18,401 | 26,599 | +8,198 | 0.03 | 0.04 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 37,349 | 44,592 | +7,243 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 12,645 | 19,249 | +6,604 | 0.02 | 0.01 | -0.01 | buy |
| CITIGROUP INC | 58,264 | 64,526 | +6,262 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 158,630 | 164,392 | +5,762 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 530,669 | 536,112 | +5,443 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 16,196 | 21,349 | +5,153 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,062 | 15,025 | +4,963 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 24,920 | 29,770 | +4,850 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 45,042 | 49,749 | +4,707 | 0.00 | 0.00 | -0.00 | buy |
| M&T BANK CORP | 27,137 | 31,673 | +4,536 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 15,669 | 19,220 | +3,551 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 19,525 | 22,825 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 430,484 | 433,531 | +3,047 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 2,386,600 | 2,389,600 | +3,000 | 0.95 | 0.88 | -0.07 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,015 | 14,295 | +2,280 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 37,180 | 39,437 | +2,257 | 0.01 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 16,592 | 18,669 | +2,077 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,203 | 14,570 | +1,367 | 0.04 | 0.03 | -0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,161 | 36,514 | +1,353 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 1,630 | 2,885 | +1,255 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 38,363 | 39,407 | +1,044 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 797 | +797 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 139,741 | 140,518 | +777 | 0.01 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 87,123 | 87,877 | +754 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 674 | +674 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 36,673 | 37,254 | +581 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 488 | +488 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 8,809 | 9,268 | +459 | 0.01 | 0.01 | -0.00 | buy |
| AlphaQuest LLC | 10 | 439 | +429 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 435,943 | 436,241 | +298 | 0.05 | 0.04 | -0.01 | buy |
| Venturi Wealth Management, LLC | 0 | 242 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,793 | 13,946 | +153 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 197 | 315 | +118 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 314 | 432 | +118 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,486 | 3,601 | +115 | 0.04 | 0.03 | -0.01 | buy |
| Smartleaf Asset Management LLC | 110 | 213 | +103 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,662 | 1,733 | +71 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 240 | 281 | +41 | 0.00 | 0.00 | -0.00 | buy |
| Global Retirement Partners, LLC | 22 | 57 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 7,477 | 7,507 | +30 | 0.00 | 0.00 | -0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 22 | 37 | +15 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 12 | 13 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 3 | 4 | +1 | 0.00 | 0.00 | 0.00 | buy |
| CANADA LIFE ASSURANCE Co | 14,524 | 14,524 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 90,870 | 90,870 | 0 | 0.01 | 0.01 | -0.00 | hold |