| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 2,561,950 | 2,895,467 | +333,517 | 1.85 | 1.89 | +0.04 | buy |
| CITADEL ADVISORS LLC | 89,589 | 97,546 | +7,957 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,886 | 18,832 | +2,946 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 4 | 47 | +43 | 0.00 | 0.00 | +0.00 | buy |
| VILLERE ST DENIS J & CO LLC | 71,158 | 71,158 | 0 | 0.04 | 0.06 | +0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 11,992 | 11,992 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 365,000 | 365,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AWM Investment Company, Inc. | 1,672,168 | 1,672,168 | 0 | 1.02 | 1.05 | +0.03 | hold |
| Allworth Financial LP | 750 | 750 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aristides Capital LLC | 218,510 | 218,510 | 0 | 0.40 | 0.40 | +0.01 | hold |
| Solas Capital Management, LLC | 1,924,617 | 1,924,617 | 0 | 6.08 | 7.45 | +1.37 | hold |
| Cable Car Capital, LP | 1,382,339 | 1,382,339 | 0 | 2.62 | 0.21 | -2.41 | hold |
| Steward Partners Investment Advisory, LLC | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 61,596 | 61,596 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 5,292 | 5,292 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 19,824 | 19,824 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 567,616 | 545,816 | -21,800 | 0.54 | 0.56 | +0.03 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 256,393 | 189,148 | -67,245 | 0.03 | 0.03 | -0.01 | sell |
| CANTOR FITZGERALD, L. P. | 188,631 | 108,918 | -79,713 | 0.04 | 0.02 | -0.02 | sell |
| Ikarian Capital, LLC | 1,056,259 | 836,259 | -220,000 | 0.83 | 0.99 | +0.16 | sell |