| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 115,142 | 2,070,784 | +1,955,642 | 0.11 | 1.78 | +1.67 | buy |
| Solas Capital Management, LLC | 1,282,192 | 1,968,052 | +685,860 | 5.09 | 7.26 | +2.16 | buy |
| AWM Investment Company, Inc. | 1,095,652 | 1,672,168 | +576,516 | 0.67 | 1.05 | +0.38 | buy |
| Alyeska Investment Group, L.P. | 0 | 365,000 | +365,000 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 338,752 | 567,616 | +228,864 | 0.52 | 0.77 | +0.25 | buy |
| Cable Car Capital, LP | 869,002 | 1,060,212 | +191,210 | 2.42 | 0.43 | -2.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 163,431 | +163,431 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 0 | 118,421 | +118,421 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 946,259 | 1,056,259 | +110,000 | 1.25 | 0.89 | -0.36 | buy |
| Aristides Capital LLC | 165,458 | 215,458 | +50,000 | 0.32 | 0.48 | +0.17 | buy |
| TWO SIGMA INVESTMENTS, LP | 22,728 | 57,572 | +34,844 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 34,706 | +34,706 | 0.00 | 0.00 | +0.00 | buy |
| Green Alpha Advisors, LLC | 0 | 11,126 | +11,126 | 0.00 | 0.07 | +0.07 | buy |
| VILLERE ST DENIS J & CO LLC | 65,258 | 73,875 | +8,617 | 0.04 | 0.05 | +0.01 | buy |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 17,824 | 19,824 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| Allworth Financial LP | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,992 | 11,992 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 61,596 | 61,596 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 5,292 | 5,292 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 13,642 | 12,501 | -1,141 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,648 | 0 | -1,648 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 17,250 | 0 | -17,250 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 72,212 | 53,203 | -19,009 | 0.00 | 0.00 | -0.00 | sell |
| Zullo Investment Group, Inc. | 19,500 | 0 | -19,500 | 0.05 | 0.00 | -0.05 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 291,868 | 256,393 | -35,475 | 0.05 | 0.04 | -0.01 | sell |
| SALEM INVESTMENT COUNSELORS INC | 45,402 | 0 | -45,402 | 0.01 | 0.00 | -0.01 | sell |
| Connective Capital Management, LLC | 47,931 | 0 | -47,931 | 0.29 | 0.00 | -0.29 | sell |
| CORSAIR CAPITAL MANAGEMENT, L.P. | 134,898 | 0 | -134,898 | 0.16 | 0.00 | -0.16 | sell |