| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,012,517 | 4,155,375 | +2,142,858 | 1.86 | 4.92 | +3.06 | buy |
| Paradigm Biocapital Advisors LP | 2,312,919 | 3,124,749 | +811,830 | 3.86 | 5.15 | +1.29 | buy |
| STEMPOINT CAPITAL LP | 249,575 | 619,789 | +370,214 | 2.39 | 7.75 | +5.36 | buy |
| JENNISON ASSOCIATES LLC | 2,547,683 | 2,817,854 | +270,171 | 0.07 | 0.09 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 2,417,493 | 2,654,729 | +237,236 | 0.06 | 0.08 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,255,512 | 1,476,203 | +220,691 | 1.00 | 1.21 | +0.21 | buy |
| LORD, ABBETT & CO. LLC | 777,288 | 964,568 | +187,280 | 0.10 | 0.15 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,039,957 | 5,226,297 | +186,340 | 2.16 | 2.44 | +0.28 | buy |
| Integral Health Asset Management, LLC | 200,000 | 325,000 | +125,000 | 1.03 | 1.49 | +0.47 | buy |
| Laurion Capital Management LP | 568,982 | 630,182 | +61,200 | 0.17 | 0.25 | +0.08 | buy |
| NEOS Investment Management LLC | 13,481 | 40,449 | +26,968 | 0.05 | 0.12 | +0.07 | buy |
| Affinity Asset Advisors, LLC | 447,095 | 470,000 | +22,905 | 3.17 | 3.58 | +0.41 | buy |
| HighMark Wealth Management LLC | 4,250 | 17,215 | +12,965 | 0.11 | 0.50 | +0.39 | buy |
| ALPS ADVISORS INC | 46,025 | 54,969 | +8,944 | 0.01 | 0.02 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 7,721 | 13,364 | +5,643 | 0.05 | 0.08 | +0.03 | buy |
| AWM Investment Company, Inc. | 50,000 | 55,000 | +5,000 | 0.23 | 0.34 | +0.10 | buy |
| Woodline Partners LP | 150,000 | 153,395 | +3,395 | 0.06 | 0.07 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 7,900 | 11,100 | +3,200 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 478,234 | 480,588 | +2,354 | 3.98 | 3.62 | -0.36 | buy |
| Informed Momentum Co LLC | 105,005 | 106,614 | +1,609 | 0.66 | 0.78 | +0.11 | buy |
| Hennion & Walsh Asset Management, Inc. | 37,160 | 38,087 | +927 | 0.08 | 0.10 | +0.02 | buy |
| Pier Capital, LLC | 116,603 | 116,570 | -33 | 0.59 | 0.75 | +0.16 | sell |
| VIRTUS ADVISERS, LLC | 2,654 | 2,479 | -175 | 0.06 | 0.06 | +0.00 | sell |
| Novo Holdings A/S | 1,100,000 | 1,098,600 | -1,400 | 2.42 | 3.55 | +1.13 | sell |
| E Fund Management Co., Ltd. | 13,069 | 10,248 | -2,821 | 0.03 | 0.03 | +0.00 | sell |
| Fisher Asset Management, LLC | 441,295 | 436,023 | -5,272 | 0.01 | 0.01 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 87,500 | 78,403 | -9,097 | 1.75 | 2.38 | +0.63 | sell |
| Parkman Healthcare Partners LLC | 120,652 | 101,119 | -19,533 | 0.61 | 0.58 | -0.03 | sell |
| Entropy Technologies, LP | 38,384 | 10,878 | -27,506 | 0.25 | 0.05 | -0.20 | sell |
| Lisanti Capital Growth, LLC | 100,245 | 69,225 | -31,020 | 0.84 | 0.79 | -0.05 | sell |
| Ikarian Capital, LLC | 680,370 | 643,751 | -36,619 | 6.62 | 8.20 | +1.57 | sell |
| GW&K Investment Management, LLC | 479,063 | 388,066 | -90,997 | 0.16 | 0.16 | +0.00 | sell |
| Opaleye Management Inc. | 307,500 | 210,000 | -97,500 | 2.91 | 2.14 | -0.77 | sell |
| BNP Paribas Asset Management Holding S.A. | 658,289 | 542,708 | -115,581 | 0.07 | 0.07 | +0.00 | sell |
| Saturn V Capital Management LP | 787,132 | 660,143 | -126,989 | 10.72 | 12.39 | +1.67 | sell |
| Candriam S.C.A. | 288,011 | 88,005 | -200,006 | 0.07 | 0.03 | -0.04 | sell |
| ORBIMED ADVISORS LLC | 1,667,360 | 1,385,000 | -282,360 | 1.19 | 1.19 | +0.00 | sell |
| First Light Asset Management, LLC | 1,987,772 | 1,690,177 | -297,595 | 5.69 | 6.06 | +0.37 | sell |