| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 2,012,517 | 4,155,375 | +2,142,858 | 1.86 | 4.94 | +3.08 | buy |
| Point72 Asset Management, L.P. | 3,416,900 | 4,949,486 | +1,532,586 | 0.37 | 0.67 | +0.30 | buy |
| JANUS HENDERSON GROUP PLC | 543,263 | 1,978,172 | +1,434,909 | 0.01 | 0.05 | +0.04 | buy |
| Artal Group S.A. | 0 | 1,390,477 | +1,390,477 | 0.00 | 1.68 | +1.68 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,008,858 | 3,823,218 | +814,360 | 0.01 | 0.02 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 2,312,919 | 3,124,749 | +811,830 | 3.86 | 5.15 | +1.29 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 632,133 | +632,133 | 0.00 | 0.06 | +0.06 | buy |
| Fiera Capital Corp | 0 | 475,510 | +475,510 | 0.00 | 0.06 | +0.06 | buy |
| FMR LLC | 4,043,865 | 4,463,676 | +419,811 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 249,575 | 619,789 | +370,214 | 2.39 | 7.75 | +5.36 | buy |
| Duquesne Family Office LLC | 0 | 309,000 | +309,000 | 0.00 | 0.39 | +0.39 | buy |
| Rock Springs Capital Management LP | 0 | 289,400 | +289,400 | 0.00 | 0.34 | +0.34 | buy |
| JPMORGAN CHASE & CO | 93,104 | 375,986 | +282,882 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 2,547,683 | 2,817,854 | +270,171 | 0.07 | 0.09 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 2,417,493 | 2,654,729 | +237,236 | 0.06 | 0.08 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,255,512 | 1,476,203 | +220,691 | 1.00 | 1.22 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 650,173 | 864,107 | +213,934 | 0.00 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 777,288 | 964,568 | +187,280 | 0.10 | 0.15 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,039,957 | 5,226,297 | +186,340 | 2.16 | 2.44 | +0.28 | buy |
| Ensign Peak Advisors, Inc | 435,685 | 621,507 | +185,822 | 0.03 | 0.05 | +0.02 | buy |
| Decheng Capital LLC | 0 | 157,958 | +157,958 | 0.00 | 0.99 | +0.99 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 63,175 | 211,820 | +148,645 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 22,792 | 171,424 | +148,632 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 102,311 | 248,050 | +145,739 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 127,835 | +127,835 | 0.00 | 1.68 | +1.68 | buy |
| Integral Health Asset Management, LLC | 200,000 | 325,000 | +125,000 | 1.03 | 1.49 | +0.47 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,725 | 152,492 | +124,767 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 138,465 | 247,803 | +109,338 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 85,765 | +85,765 | 0.00 | 0.98 | +0.98 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 184,107 | 257,145 | +73,038 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 3,502,452 | 3,575,076 | +72,624 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 72,100 | +72,100 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 67,293 | 135,293 | +68,000 | 0.02 | 0.05 | +0.03 | buy |
| Laurion Capital Management LP | 568,982 | 630,182 | +61,200 | 0.73 | 0.82 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 176,426 | 235,198 | +58,772 | 0.01 | 0.01 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 56,402 | +56,402 | 0.00 | 0.45 | +0.45 | buy |
| Russell Investments Group, Ltd. | 14 | 51,334 | +51,320 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,352,672 | 1,401,403 | +48,731 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,942 | 68,840 | +47,898 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 41,932 | +41,932 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 57,715 | 94,867 | +37,152 | 0.00 | 0.01 | +0.00 | buy |
| Calamos Advisors LLC | 0 | 29,000 | +29,000 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 73,457 | 101,737 | +28,280 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 13,481 | 40,449 | +26,968 | 0.05 | 0.12 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,966 | 107,665 | +26,699 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,682 | 50,282 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 447,095 | 470,000 | +22,905 | 3.17 | 3.58 | +0.41 | buy |
| Swiss National Bank | 104,200 | 126,500 | +22,300 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.49 | +0.49 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 144,911 | 162,526 | +17,615 | 0.17 | 0.21 | +0.03 | buy |
| ALGERT GLOBAL LLC | 17,680 | 35,040 | +17,360 | 0.03 | 0.06 | +0.04 | buy |
| Orion Porfolio Solutions, LLC | 0 | 15,559 | +15,559 | 0.00 | 0.01 | +0.01 | buy |
| HighMark Wealth Management LLC | 4,250 | 17,215 | +12,965 | 0.11 | 0.50 | +0.39 | buy |
| SEI INVESTMENTS CO | 16,865 | 29,669 | +12,804 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 344,413 | 357,142 | +12,729 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 10,786 | +10,786 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 10,773 | +10,773 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 10,663 | +10,663 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 10,212 | +10,212 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 54,105 | 63,952 | +9,847 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 46,025 | 54,969 | +8,944 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 470,373 | 478,532 | +8,159 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 7,841 | +7,841 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 136,945 | 144,634 | +7,689 | 0.01 | 0.01 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 7,100 | +7,100 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 6,876 | +6,876 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 57,871 | 64,292 | +6,421 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,967 | +5,967 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,721 | 13,364 | +5,643 | 0.05 | 0.08 | +0.03 | buy |
| Snowden Capital Advisors LLC | 0 | 5,135 | +5,135 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 171,837 | 176,943 | +5,106 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 0 | 5,088 | +5,088 | 0.00 | 0.06 | +0.06 | buy |
| Jefferies Financial Group Inc. | 0 | 5,020 | +5,020 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 50,000 | 55,000 | +5,000 | 0.23 | 0.34 | +0.10 | buy |
| Atom Investors LP | 0 | 4,887 | +4,887 | 0.00 | 0.03 | +0.03 | buy |
| OPPENHEIMER & CO INC | 0 | 4,674 | +4,674 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 4,418 | +4,418 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 4,276 | +4,276 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 21,015 | 25,025 | +4,010 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 205 | 4,163 | +3,958 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 18 | 3,477 | +3,459 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 150,000 | 153,395 | +3,395 | 0.06 | 0.07 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 7,900 | 11,100 | +3,200 | 0.00 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 14,789 | 17,585 | +2,796 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 6,631 | 9,367 | +2,736 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 478,234 | 480,588 | +2,354 | 3.98 | 3.62 | -0.36 | buy |
| Belvedere Trading LLC | 0 | 2,114 | +2,114 | 0.00 | 0.01 | +0.01 | buy |
| NATIXIS ADVISORS, LLC | 25,541 | 27,424 | +1,883 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,198 | 14,001 | +1,803 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,786 | +1,786 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,076 | 16,731 | +1,655 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 105,005 | 106,614 | +1,609 | 0.66 | 0.78 | +0.11 | buy |
| IFP Advisors, Inc | 0 | 1,490 | +1,490 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 107,215 | 108,693 | +1,478 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 439 | 1,552 | +1,113 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,011 | +1,011 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 37,160 | 38,087 | +927 | 0.08 | 0.10 | +0.02 | buy |
| Handelsbanken Fonder AB | 12,500 | 13,300 | +800 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 705 | +705 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8,674 | 9,183 | +509 | 0.00 | 0.00 | +0.00 | buy |