| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Novo Holdings A/S | 960,215 | 1,275,000 | +314,785 | 2.97 | 3.25 | +0.28 | buy |
| Fisher Asset Management, LLC | 559,287 | 773,347 | +214,060 | 0.01 | 0.01 | -0.00 | buy |
| Aberdeen Group plc | 43,389 | 208,059 | +164,670 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,141,014 | 6,239,902 | +98,888 | 2.59 | 2.02 | -0.57 | buy |
| Siren, L.L.C. | 1,609,652 | 1,688,611 | +78,959 | 3.64 | 3.19 | -0.44 | buy |
| AWM Investment Company, Inc. | 55,000 | 95,000 | +40,000 | 0.34 | 0.44 | +0.10 | buy |
| Paradigm Biocapital Advisors LP | 1,910,761 | 1,946,168 | +35,407 | 3.40 | 3.00 | -0.39 | buy |
| BNP Paribas Asset Management Holding S.A. | 576,068 | 610,839 | +34,771 | 0.07 | 0.05 | -0.02 | buy |
| Hood River Capital Management LLC | 851,400 | 872,635 | +21,235 | 0.64 | 0.50 | -0.14 | buy |
| MPM BioImpact LLC | 617,035 | 631,964 | +14,929 | 4.48 | 3.64 | -0.84 | buy |
| Parkman Healthcare Partners LLC | 51,133 | 63,940 | +12,807 | 0.35 | 0.25 | -0.09 | buy |
| Lewis Asset Management, LLC | 9,780 | 20,000 | +10,220 | 0.38 | 0.55 | +0.17 | buy |
| Decheng Capital LLC | 167,958 | 177,958 | +10,000 | 1.84 | 1.67 | -0.17 | buy |
| Ikarian Capital, LLC | 516,431 | 523,431 | +7,000 | 7.54 | 5.72 | -1.82 | buy |
| PROFUND ADVISORS LLC | 16,885 | 21,917 | +5,032 | 0.03 | 0.03 | +0.00 | buy |
| E Fund Management Co., Ltd. | 5,775 | 9,545 | +3,770 | 0.01 | 0.02 | +0.00 | buy |
| Pier Capital, LLC | 111,999 | 113,412 | +1,413 | 0.82 | 0.64 | -0.18 | buy |
| SECTORAL ASSET MANAGEMENT INC | 4,400 | 5,710 | +1,310 | 0.15 | 0.15 | -0.00 | buy |
| NEOS Investment Management LLC | 57,933 | 58,807 | +874 | 0.07 | 0.04 | -0.03 | buy |
| TEMA ETFS LLC | 57,933 | 58,807 | +874 | 1.23 | 0.59 | -0.64 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,947 | 2,375 | +428 | 0.00 | 0.00 | -0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 293 | 604 | +311 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 7 | 72 | +65 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 81 | 64 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 59,125 | 59,017 | -108 | 1.18 | 1.00 | -0.18 | sell |
| GILDER GAGNON HOWE & CO LLC | 25,044 | 24,470 | -574 | 0.01 | 0.01 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 19,664 | 18,664 | -1,000 | 0.09 | 0.06 | -0.04 | sell |
| SEGALL BRYANT & HAMILL, LLC | 150,398 | 146,274 | -4,124 | 0.11 | 0.08 | -0.03 | sell |
| MOODY ALDRICH PARTNERS LLC | 144,366 | 139,905 | -4,461 | 1.37 | 0.98 | -0.38 | sell |
| Bryce Point Capital, LLC | 22,686 | 17,371 | -5,315 | 0.34 | 0.46 | +0.12 | sell |
| Hennion & Walsh Asset Management, Inc. | 40,090 | 32,580 | -7,510 | 0.09 | 0.05 | -0.04 | sell |
| ALPS ADVISORS INC | 74,985 | 67,303 | -7,682 | 0.02 | 0.01 | -0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 22,484 | 6,701 | -15,783 | 0.03 | 0.01 | -0.02 | sell |
| Fiera Capital Corp | 454,982 | 438,337 | -16,645 | 0.07 | 0.05 | -0.02 | sell |
| First Light Asset Management, LLC | 885,453 | 855,419 | -30,034 | 4.33 | 3.28 | -1.06 | sell |
| Integral Health Asset Management, LLC | 300,000 | 125,000 | -175,000 | 1.36 | 0.46 | -0.89 | sell |
| Affinity Asset Advisors, LLC | 460,000 | 152,252 | -307,748 | 3.67 | 0.80 | -2.87 | sell |
| T. Rowe Price Investment Management, Inc. | 1,002,882 | 689,265 | -313,617 | 0.03 | 0.02 | -0.02 | sell |
| Cormorant Asset Management, LP | 1,000,000 | 600,000 | -400,000 | 2.81 | 1.51 | -1.29 | sell |
| JENNISON ASSOCIATES LLC | 2,708,351 | 2,119,767 | -588,584 | 0.08 | 0.05 | -0.03 | sell |