| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,928,086 | 14,031,269 | +5,103,183 | 0.03 | 0.03 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 1,500,000 | +1,500,000 | 0.00 | 3.59 | +3.59 | buy |
| JANUS HENDERSON GROUP PLC | 2,795,441 | 3,424,442 | +629,001 | 0.07 | 0.07 | -0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,075,098 | 4,605,098 | +530,000 | 1.10 | 0.83 | -0.27 | buy |
| Candriam S.C.A. | 0 | 488,911 | +488,911 | 0.00 | 0.10 | +0.10 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 2.09 | +2.09 | buy |
| Novo Holdings A/S | 960,215 | 1,275,000 | +314,785 | 2.97 | 3.25 | +0.28 | buy |
| STATE STREET CORP | 2,990,838 | 3,283,275 | +292,437 | 0.01 | 0.00 | -0.00 | buy |
| M&G Plc | 0 | 281,822 | +281,822 | 0.00 | 0.05 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 477,298 | 719,578 | +242,280 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 679,123 | 920,020 | +240,897 | 0.30 | 0.29 | -0.01 | buy |
| VANGUARD GROUP INC | 9,089,391 | 9,311,600 | +222,209 | 0.01 | 0.01 | -0.00 | buy |
| Fisher Asset Management, LLC | 559,287 | 773,347 | +214,060 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 219,524 | 429,063 | +209,539 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 848,050 | 1,047,015 | +198,965 | 0.05 | 0.04 | -0.01 | buy |
| Aberdeen Group plc | 43,389 | 208,059 | +164,670 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 7,515,193 | 7,656,569 | +141,376 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 139,492 | +139,492 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 34,200 | 166,338 | +132,138 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,141,014 | 6,239,902 | +98,888 | 2.59 | 2.02 | -0.57 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,098,841 | 2,190,932 | +92,091 | 0.01 | 0.01 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,251 | 138,035 | +87,784 | 0.00 | 0.01 | +0.00 | buy |
| Caption Management, LLC | 0 | 86,713 | +86,713 | 0.00 | 0.13 | +0.13 | buy |
| Siren, L.L.C. | 1,609,652 | 1,688,611 | +78,959 | 3.64 | 3.19 | -0.44 | buy |
| BANK OF AMERICA CORP /DE/ | 235,281 | 304,926 | +69,645 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 51,295 | +51,295 | 0.00 | 1.54 | +1.54 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,361 | 77,461 | +48,100 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 43,613 | +43,613 | 0.00 | 1.74 | +1.74 | buy |
| AWM Investment Company, Inc. | 55,000 | 95,000 | +40,000 | 0.34 | 0.44 | +0.10 | buy |
| Paradigm Biocapital Advisors LP | 1,910,761 | 1,946,168 | +35,407 | 3.40 | 3.00 | -0.39 | buy |
| BNP Paribas Asset Management Holding S.A. | 576,068 | 610,839 | +34,771 | 0.07 | 0.05 | -0.02 | buy |
| CITADEL ADVISORS LLC | 4,722 | 38,551 | +33,829 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 120,759 | 150,050 | +29,291 | 0.01 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 325,276 | 347,581 | +22,305 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 851,400 | 872,635 | +21,235 | 0.64 | 0.50 | -0.14 | buy |
| Rafferty Asset Management, LLC | 81,257 | 102,131 | +20,874 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 19,723 | +19,723 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 18,800 | +18,800 | 0.00 | 0.01 | +0.01 | buy |
| State of New Jersey Common Pension Fund D | 38,049 | 55,878 | +17,829 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 617,035 | 631,964 | +14,929 | 4.48 | 3.64 | -0.84 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 43,105 | 56,950 | +13,845 | 0.02 | 0.02 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,959 | +12,959 | 0.00 | 0.04 | +0.04 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 27,687 | 40,613 | +12,926 | 0.04 | 0.03 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 51,133 | 63,940 | +12,807 | 0.35 | 0.25 | -0.09 | buy |
| CIBC WORLD MARKETS CORP | 8,206 | 20,335 | +12,129 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 502,690 | 514,809 | +12,119 | 0.05 | 0.03 | -0.01 | buy |
| Lewis Asset Management, LLC | 9,780 | 20,000 | +10,220 | 0.38 | 0.55 | +0.17 | buy |
| Decheng Capital LLC | 167,958 | 177,958 | +10,000 | 1.84 | 1.67 | -0.17 | buy |
| MORGAN STANLEY | 505,040 | 514,684 | +9,644 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 9,388 | +9,388 | 0.00 | 0.14 | +0.14 | buy |
| Verition Fund Management LLC | 17,217 | 26,458 | +9,241 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 9,182 | +9,182 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 101,720 | 110,674 | +8,954 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 334,783 | 342,734 | +7,951 | 0.03 | 0.02 | -0.01 | buy |
| Pathstone Holdings, LLC | 20,428 | 28,315 | +7,887 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 124,078 | 131,950 | +7,872 | 0.01 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 7,224 | 14,898 | +7,674 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 7,431 | +7,431 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 7,048 | +7,048 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 516,431 | 523,431 | +7,000 | 7.54 | 5.72 | -1.82 | buy |
| FIDUCIARY TRUST CO | 0 | 6,895 | +6,895 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 6,688 | +6,688 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,163 | 59,311 | +6,148 | 0.01 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 16,885 | 21,917 | +5,032 | 0.03 | 0.03 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 26,143 | 30,841 | +4,698 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 5,775 | 9,545 | +3,770 | 0.01 | 0.02 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 3,237 | +3,237 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 26,836 | 29,914 | +3,078 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,953 | +2,953 | 0.00 | 0.03 | +0.03 | buy |
| Kestra Investment Management, LLC | 0 | 2,839 | +2,839 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 159,400 | 161,800 | +2,400 | 0.01 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 137,752 | 139,973 | +2,221 | 0.21 | 0.16 | -0.05 | buy |
| COMMERCE BANK | 4,125 | 6,320 | +2,195 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 4,913 | 6,674 | +1,761 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,588 | +1,588 | 0.00 | 0.00 | +0.00 | buy |
| Pier Capital, LLC | 111,999 | 113,412 | +1,413 | 0.82 | 0.64 | -0.18 | buy |
| SECTORAL ASSET MANAGEMENT INC | 4,400 | 5,710 | +1,310 | 0.15 | 0.15 | -0.00 | buy |
| Corebridge Financial, Inc. | 43,599 | 44,896 | +1,297 | 0.01 | 0.01 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 16,721 | 17,680 | +959 | 0.01 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 12,552 | 13,489 | +937 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 57,933 | 58,807 | +874 | 0.07 | 0.04 | -0.03 | buy |
| TEMA ETFS LLC | 57,933 | 58,807 | +874 | 1.23 | 0.59 | -0.64 | buy |
| NATIXIS ADVISORS, LLC | 45,683 | 46,509 | +826 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,920 | 19,679 | +759 | 0.01 | 0.01 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,559 | 3,247 | +688 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 6,284 | 6,857 | +573 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 2,692 | 3,159 | +467 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 23,469 | 23,899 | +430 | 0.01 | 0.01 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,947 | 2,375 | +428 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 53,020 | 53,414 | +394 | 0.01 | 0.01 | -0.01 | buy |
| KBC Group NV | 3,712 | 4,082 | +370 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 82 | 423 | +341 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 293 | 604 | +311 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 191 | +191 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 177 | +177 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 106 | 202 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 985 | 1,070 | +85 | 0.01 | 0.00 | -0.00 | buy |
| MATHER GROUP, LLC. | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 7 | 72 | +65 | 0.00 | 0.00 | +0.00 | buy |