| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,293,775 | 15,759,799 | +1,466,024 | 0.03 | 0.03 | -0.00 | buy |
| BlackRock, Inc. | 7,988,548 | 8,478,815 | +490,267 | 0.01 | 0.01 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 6,933,098 | 8,338,098 | +1,405,000 | 1.68 | 1.80 | +0.12 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,037,889 | 8,157,204 | +119,315 | 0.07 | 0.06 | -0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,387,740 | 6,395,922 | +8,182 | 2.02 | 1.71 | -0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,224,387 | 5,355,496 | +131,109 | 0.03 | 0.02 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,440,691 | 4,520,251 | +79,560 | 0.09 | 0.08 | -0.01 | buy |
| EcoR1 Capital, LLC | 4,288,120 | 4,288,120 | 0 | 9.11 | 6.66 | -2.46 | hold |
| Bellevue Group AG | 4,040 | 3,280,000 | +3,275,960 | 0.00 | 2.84 | +2.83 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,242,631 | 2,480,763 | +238,132 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,161,378 | 2,403,046 | +241,668 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,648,869 | 2,351,465 | +702,596 | 0.45 | 0.49 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 59,121 | 1,940,622 | +1,881,501 | 0.00 | 0.05 | +0.05 | buy |
| Siren, L.L.C. | 1,507,636 | 1,903,636 | +396,000 | 2.09 | 1.92 | -0.18 | buy |
| Pictet Asset Management Holding SA | 1,560,300 | 1,884,281 | +323,981 | 0.07 | 0.07 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,327,382 | 1,716,445 | +389,063 | 0.07 | 0.07 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,476,325 | 1,618,686 | +142,361 | 0.59 | 0.52 | -0.08 | buy |
| Novo Holdings A/S | 1,625,000 | 1,550,000 | -75,000 | 5.87 | 4.56 | -1.31 | sell |
| RTW INVESTMENTS, LP | 1,351,326 | 1,451,326 | +100,000 | 0.63 | 0.52 | -0.11 | buy |
| JPMORGAN CHASE & CO | 1,154,710 | 1,324,668 | +169,958 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 309,368 | 1,139,331 | +829,963 | 1.08 | 2.49 | +1.41 | buy |
| First Light Asset Management, LLC | 1,194,263 | 1,089,670 | -104,593 | 4.25 | 3.55 | -0.70 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,068,878 | 1,052,858 | -16,020 | 0.03 | 0.02 | -0.01 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,043,879 | +1,043,879 | 0.00 | 1.03 | +1.03 | buy |
| ORBIMED ADVISORS LLC | 999,000 | 999,000 | 0 | 0.95 | 0.79 | -0.16 | hold |
| MORGAN STANLEY | 768,826 | 919,686 | +150,860 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 897,403 | 907,412 | +10,009 | 0.46 | 0.33 | -0.13 | buy |
| JENNISON ASSOCIATES LLC | 1,281,601 | 904,672 | -376,929 | 0.04 | 0.02 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 548,977 | 852,258 | +303,281 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 769,823 | 841,301 | +71,478 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 781,981 | 833,418 | +51,437 | 0.01 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 830,961 | 830,961 | 0 | 0.19 | 0.16 | -0.04 | hold |
| Aberdeen Group plc | 674,533 | 820,395 | +145,862 | 0.05 | 0.05 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 601,190 | 798,334 | +197,144 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 758,659 | 762,702 | +4,043 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 801,314 | 716,125 | -85,189 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 684,108 | +684,108 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 567,127 | 628,155 | +61,028 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 578,455 | 589,654 | +11,199 | 0.09 | 0.07 | -0.01 | buy |
| UBS Group AG | 908,192 | 571,899 | -336,293 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 522,466 | 551,464 | +28,998 | 0.01 | 0.01 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 408,312 | 425,616 | +17,304 | 0.03 | 0.03 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 187,433 | 382,363 | +194,930 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 405,010 | 358,719 | -46,291 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 262,904 | 350,000 | +87,096 | 2.53 | 2.08 | -0.44 | buy |
| Impax Asset Management Group plc | 275,000 | 350,000 | +75,000 | 0.08 | 0.09 | +0.01 | buy |
| BRAUN STACEY ASSOCIATES INC | 0 | 324,808 | +324,808 | 0.00 | 0.39 | +0.39 | buy |
| CITADEL ADVISORS LLC | 254,720 | 317,934 | +63,214 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 302,001 | 306,039 | +4,038 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 235,018 | 257,525 | +22,507 | 0.00 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 300,000 | 250,000 | -50,000 | 0.79 | 0.46 | -0.33 | sell |
| Sio Capital Management, LLC | 124,841 | 249,887 | +125,046 | 0.96 | 1.31 | +0.34 | buy |
| TD ASSET MANAGEMENT INC | 190,478 | 234,892 | +44,414 | 0.01 | 0.01 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 225,842 | 230,128 | +4,286 | 0.00 | 0.00 | -0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 212,010 | +212,010 | 0.00 | 1.67 | +1.67 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 171,830 | 195,701 | +23,871 | 0.44 | 0.40 | -0.04 | buy |
| MOODY ALDRICH PARTNERS LLC | 110,415 | 183,438 | +73,023 | 0.96 | 1.20 | +0.24 | buy |
| SEGALL BRYANT & HAMILL, LLC | 189,477 | 180,112 | -9,365 | 0.12 | 0.07 | -0.05 | sell |
| Swiss National Bank | 176,500 | 176,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 93,020 | 170,949 | +77,929 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 144,239 | 163,633 | +19,394 | 0.05 | 0.04 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 130,363 | 150,659 | +20,296 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 148,489 | 147,680 | -809 | 0.01 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 146,123 | 141,618 | -4,505 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 158,089 | 133,466 | -24,623 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 115,752 | 118,420 | +2,668 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 119,905 | 107,875 | -12,030 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 185,677 | 106,734 | -78,943 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,568 | 105,563 | +19,995 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 100,000 | 100,000 | 0 | 0.45 | 0.40 | -0.05 | hold |
| Burkehill Global Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.18 | +0.18 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 138,685 | 99,364 | -39,321 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 97,802 | +97,802 | 0.00 | 0.05 | +0.05 | buy |
| XTX Topco Ltd | 0 | 97,166 | +97,166 | 0.00 | 0.06 | +0.06 | buy |
| SECTOR GAMMA AS | 115,000 | 94,195 | -20,805 | 1.22 | 0.81 | -0.41 | sell |
| TWO SIGMA INVESTMENTS, LP | 49,699 | 87,299 | +37,600 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 77,765 | 85,232 | +7,467 | 0.02 | 0.01 | -0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 83,617 | +83,617 | 0.00 | 0.17 | +0.17 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 100,567 | 79,755 | -20,812 | 0.01 | 0.01 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 275,616 | 75,424 | -200,192 | 0.02 | 0.01 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.25 | 0.16 | -0.09 | hold |
| Legal & General Group Plc | 87,802 | 74,355 | -13,447 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 72,045 | 73,961 | +1,916 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 139,461 | 73,652 | -65,809 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 55,561 | 65,232 | +9,671 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 300,335 | 62,368 | -237,967 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 49,818 | 54,326 | +4,508 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 47,321 | 53,637 | +6,316 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 33,150 | 51,365 | +18,215 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 47,295 | 49,778 | +2,483 | 0.00 | 0.00 | -0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 46,552 | 48,724 | +2,172 | 0.03 | 0.02 | -0.01 | buy |
| Man Group plc | 62,560 | 47,580 | -14,980 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,511 | 46,253 | +12,742 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,021 | +46,021 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,002 | 45,847 | +3,845 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,533 | 45,269 | +17,736 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 33,354 | 45,192 | +11,838 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 40,230 | +40,230 | 0.00 | 0.52 | +0.52 | buy |
| Walleye Capital LLC | 4,931 | 38,042 | +33,111 | 0.00 | 0.01 | +0.01 | buy |
| Orion Porfolio Solutions, LLC | 30,495 | 37,499 | +7,004 | 0.01 | 0.01 | +0.00 | buy |