| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,226,297 | 6,112,173 | +885,876 | 2.44 | 2.65 | +0.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,971,582 | 4,620,413 | +1,648,831 | 0.02 | 0.04 | +0.01 | buy |
| VANGUARD GROUP INC | 3,575,076 | 4,514,478 | +939,402 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,823,218 | 4,406,456 | +583,238 | 0.02 | 0.02 | +0.00 | buy |
| EcoR1 Capital, LLC | 4,155,375 | 4,155,375 | 0 | 4.94 | 5.69 | +0.75 | hold |
| FMR LLC | 4,463,676 | 4,096,795 | -366,881 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 3,255,253 | 2,812,923 | -442,330 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 4,949,486 | 2,780,856 | -2,168,630 | 0.67 | 0.40 | -0.27 | sell |
| JENNISON ASSOCIATES LLC | 2,817,854 | 2,780,144 | -37,710 | 0.09 | 0.08 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 3,124,749 | 2,513,302 | -611,447 | 5.15 | 4.31 | -0.84 | sell |
| JANUS HENDERSON GROUP PLC | 1,978,172 | 2,455,661 | +477,489 | 0.05 | 0.06 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,401,403 | 1,678,387 | +276,984 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,476,203 | 1,476,203 | 0 | 1.22 | 1.60 | +0.38 | hold |
| Cormorant Asset Management, LP | 1,150,000 | 1,350,000 | +200,000 | 2.37 | 3.52 | +1.15 | buy |
| T. Rowe Price Investment Management, Inc. | 2,654,729 | 1,347,210 | -1,307,519 | 0.08 | 0.04 | -0.04 | sell |
| ORBIMED ADVISORS LLC | 1,385,000 | 1,280,800 | -104,200 | 1.19 | 1.14 | -0.05 | sell |
| First Light Asset Management, LLC | 1,690,177 | 1,200,508 | -489,669 | 6.06 | 4.71 | -1.34 | sell |
| Artal Group S.A. | 1,390,477 | 1,066,064 | -324,413 | 1.68 | 1.23 | -0.45 | sell |
| Novo Holdings A/S | 1,098,600 | 1,000,000 | -98,600 | 3.55 | 2.41 | -1.13 | sell |
| LORD, ABBETT & CO. LLC | 964,568 | 887,921 | -76,647 | 0.15 | 0.13 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 413,209 | 861,422 | +448,213 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 612,200 | 838,625 | +226,425 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,059,633 | 735,088 | -324,545 | 0.78 | 0.56 | -0.21 | sell |
| Schonfeld Strategic Advisors LLC | 135,293 | 653,557 | +518,264 | 0.05 | 0.23 | +0.18 | buy |
| GOLDMAN SACHS GROUP INC | 864,107 | 649,190 | -214,917 | 0.01 | 0.01 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 621,507 | 616,227 | -5,280 | 0.05 | 0.05 | -0.00 | sell |
| NORTHERN TRUST CORP | 601,384 | 606,037 | +4,653 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 478,532 | 597,049 | +118,517 | 0.01 | 0.01 | -0.00 | buy |
| Ikarian Capital, LLC | 643,751 | 588,818 | -54,933 | 8.20 | 8.23 | +0.03 | sell |
| MPM BioImpact LLC | 480,588 | 557,184 | +76,596 | 3.62 | 3.88 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 619,789 | 551,095 | -68,694 | 7.75 | 7.26 | -0.49 | sell |
| DIMENSIONAL FUND ADVISORS LP | 640,802 | 546,759 | -94,043 | 0.01 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 542,708 | 546,234 | +3,526 | 0.07 | 0.06 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 470,000 | 515,000 | +45,000 | 3.58 | 3.63 | +0.06 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,000 | 497,000 | +492,000 | 0.00 | 0.13 | +0.13 | buy |
| Fiera Capital Corp | 475,510 | 480,409 | +4,899 | 0.06 | 0.07 | +0.00 | buy |
| Saturn V Capital Management LP | 660,143 | 479,681 | -180,462 | 12.39 | 8.12 | -4.27 | sell |
| Fisher Asset Management, LLC | 436,023 | 444,670 | +8,647 | 0.01 | 0.01 | -0.00 | buy |
| Hood River Capital Management LLC | 0 | 410,342 | +410,342 | 0.00 | 0.38 | +0.38 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 1.49 | 1.78 | +0.29 | buy |
| Qube Research & Technologies Ltd | 94,867 | 390,941 | +296,074 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 296,478 | 386,450 | +89,972 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 388,066 | 377,663 | -10,403 | 0.16 | 0.15 | -0.01 | sell |
| First Turn Management, LLC | 0 | 369,302 | +369,302 | 0.00 | 2.69 | +2.69 | buy |
| Laurion Capital Management LP | 630,182 | 350,766 | -279,416 | 0.82 | 0.51 | -0.31 | sell |
| Walleye Capital LLC | 241,362 | 315,220 | +73,858 | 0.12 | 0.15 | +0.03 | buy |
| Duquesne Family Office LLC | 309,000 | 309,000 | 0 | 0.39 | 0.49 | +0.10 | hold |
| BANK OF AMERICA CORP /DE/ | 357,142 | 305,169 | -51,973 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 9,367 | 300,868 | +291,501 | 0.00 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 289,400 | 289,400 | 0 | 0.34 | 0.39 | +0.05 | hold |
| JPMORGAN CHASE & CO | 375,986 | 285,062 | -90,924 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 211,820 | 260,980 | +49,160 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 49,258 | 236,773 | +187,515 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 257,145 | 226,687 | -30,458 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 235,198 | 204,998 | -30,200 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 69,607 | 203,889 | +134,282 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 632,133 | 201,048 | -431,085 | 0.06 | 0.02 | -0.04 | sell |
| FIRST TRUST ADVISORS LP | 101,737 | 196,961 | +95,224 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 144,634 | 185,755 | +41,121 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 247,803 | 182,942 | -64,861 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 176,943 | 181,599 | +4,656 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 152,492 | 166,742 | +14,250 | 0.01 | 0.01 | +0.00 | buy |
| MAPLELANE CAPITAL, LLC | 0 | 160,000 | +160,000 | 0.00 | 0.54 | +0.54 | buy |
| Decheng Capital LLC | 157,958 | 157,958 | 0 | 0.99 | 2.17 | +1.18 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 162,526 | 150,924 | -11,602 | 0.21 | 0.20 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 56,402 | 150,183 | +93,781 | 0.45 | 1.31 | +0.86 | buy |
| Parkman Healthcare Partners LLC | 101,119 | 141,375 | +40,256 | 0.58 | 0.86 | +0.28 | buy |
| MARSHALL WACE, LLP | 0 | 141,204 | +141,204 | 0.00 | 0.01 | +0.01 | buy |
| New Leaf Venture Partners, L.L.C. | 141,000 | 141,000 | 0 | 5.78 | 7.68 | +1.90 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 78,403 | 135,141 | +56,738 | 2.38 | 5.10 | +2.72 | buy |
| Senator Investment Group LP | 0 | 135,000 | +135,000 | 0.00 | 0.29 | +0.29 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 107,665 | 131,063 | +23,398 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 126,500 | 130,300 | +3,800 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 125,714 | +125,714 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 171,424 | 121,879 | -49,545 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 36,924 | 119,880 | +82,956 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 74,895 | 118,354 | +43,459 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 29,119 | 116,322 | +87,203 | 0.02 | 0.06 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 114,637 | +114,637 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 108,693 | 112,319 | +3,626 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 216,849 | 112,169 | -104,680 | 0.04 | 0.02 | -0.02 | sell |
| Pier Capital, LLC | 116,570 | 108,545 | -8,025 | 0.75 | 0.72 | -0.03 | sell |
| BAKER BROS. ADVISORS LP | 0 | 103,927 | +103,927 | 0.00 | 0.06 | +0.06 | buy |
| Russell Investments Group, Ltd. | 51,334 | 102,394 | +51,060 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,270 | 92,530 | +25,260 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 85,765 | 85,765 | 0 | 0.98 | 0.99 | +0.00 | hold |
| Lisanti Capital Growth, LLC | 69,225 | 83,380 | +14,155 | 0.79 | 0.90 | +0.11 | buy |
| SG Americas Securities, LLC | 5,967 | 79,051 | +73,084 | 0.00 | 0.02 | +0.02 | buy |
| Jefferies Financial Group Inc. | 5,020 | 77,500 | +72,480 | 0.00 | 0.07 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 0 | 74,850 | +74,850 | 0.00 | 0.68 | +0.68 | buy |
| WELLS FARGO & COMPANY/MN | 68,840 | 72,920 | +4,080 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 63,952 | 68,758 | +4,806 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 101,196 | 66,196 | -35,000 | 0.01 | 0.01 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,292 | 65,536 | +1,244 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 54,969 | 61,525 | +6,556 | 0.02 | 0.02 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,111 | 60,416 | +10,305 | 0.01 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 106,614 | 57,179 | -49,435 | 0.78 | 0.42 | -0.36 | sell |
| AWM Investment Company, Inc. | 55,000 | 55,000 | 0 | 0.34 | 0.33 | -0.00 | hold |
| NEOS Investment Management LLC | 40,449 | 53,570 | +13,121 | 0.12 | 0.10 | -0.02 | buy |
| Nicholas Investment Partners, LP | 0 | 53,012 | +53,012 | 0.00 | 0.25 | +0.25 | buy |