| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,226,297 | 6,112,173 | +885,876 | 2.44 | 2.65 | +0.21 | buy |
| Cormorant Asset Management, LP | 1,150,000 | 1,350,000 | +200,000 | 2.36 | 3.49 | +1.13 | buy |
| MOODY ALDRICH PARTNERS LLC | 56,402 | 150,183 | +93,781 | 0.45 | 1.31 | +0.86 | buy |
| MPM BioImpact LLC | 480,588 | 557,184 | +76,596 | 3.62 | 3.88 | +0.26 | buy |
| Integral Health Asset Management, LLC | 325,000 | 400,000 | +75,000 | 1.49 | 1.78 | +0.29 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 78,403 | 135,141 | +56,738 | 2.38 | 5.10 | +2.71 | buy |
| Affinity Asset Advisors, LLC | 470,000 | 515,000 | +45,000 | 3.58 | 3.63 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 101,119 | 141,375 | +40,256 | 0.58 | 0.86 | +0.28 | buy |
| HighVista Strategies LLC | 15,899 | 35,237 | +19,338 | 0.27 | 0.58 | +0.31 | buy |
| Lisanti Capital Growth, LLC | 69,225 | 83,380 | +14,155 | 0.79 | 0.90 | +0.11 | buy |
| Calamos Advisors LLC | 29,000 | 42,336 | +13,336 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 40,449 | 53,570 | +13,121 | 0.12 | 0.10 | -0.02 | buy |
| Resolute Capital Asset Partners LLC | 20,000 | 30,000 | +10,000 | 0.49 | 0.77 | +0.28 | buy |
| Fisher Asset Management, LLC | 436,023 | 444,670 | +8,647 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 54,969 | 61,525 | +6,556 | 0.02 | 0.02 | +0.00 | buy |
| Fiera Capital Corp | 475,510 | 480,409 | +4,899 | 0.06 | 0.07 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 542,708 | 546,234 | +3,526 | 0.07 | 0.06 | -0.00 | buy |
| INCEPTIONR LLC | 5,088 | 8,547 | +3,459 | 0.06 | 0.11 | +0.05 | buy |
| Hennion & Walsh Asset Management, Inc. | 38,087 | 41,344 | +3,257 | 0.10 | 0.10 | -0.00 | buy |
| HighMark Wealth Management LLC | 17,215 | 19,995 | +2,780 | 0.50 | 0.54 | +0.04 | buy |
| VIRTUS ADVISERS, LLC | 2,479 | 1,931 | -548 | 0.06 | 0.04 | -0.02 | sell |
| Entropy Technologies, LP | 10,878 | 9,782 | -1,096 | 0.05 | 0.05 | -0.01 | sell |
| E Fund Management Co., Ltd. | 10,248 | 6,813 | -3,435 | 0.03 | 0.02 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 13,364 | 9,265 | -4,099 | 0.08 | 0.06 | -0.02 | sell |
| Pier Capital, LLC | 116,570 | 108,545 | -8,025 | 0.75 | 0.72 | -0.03 | sell |
| GW&K Investment Management, LLC | 388,066 | 377,663 | -10,403 | 0.16 | 0.15 | -0.01 | sell |
| Aberdeen Group plc | 101,196 | 66,196 | -35,000 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 2,817,854 | 2,780,144 | -37,710 | 0.09 | 0.08 | -0.01 | sell |
| Informed Momentum Co LLC | 106,614 | 57,179 | -49,435 | 0.78 | 0.42 | -0.36 | sell |
| Ikarian Capital, LLC | 643,751 | 588,818 | -54,933 | 8.20 | 8.23 | +0.03 | sell |
| STEMPOINT CAPITAL LP | 619,789 | 551,095 | -68,694 | 7.75 | 7.26 | -0.49 | sell |
| LORD, ABBETT & CO. LLC | 964,568 | 887,921 | -76,647 | 0.15 | 0.13 | -0.02 | sell |
| Novo Holdings A/S | 1,098,600 | 1,000,000 | -98,600 | 3.55 | 2.41 | -1.13 | sell |
| ORBIMED ADVISORS LLC | 1,385,000 | 1,280,800 | -104,200 | 1.19 | 1.14 | -0.05 | sell |
| Saturn V Capital Management LP | 660,143 | 479,681 | -180,462 | 12.39 | 8.12 | -4.27 | sell |
| Laurion Capital Management LP | 630,182 | 350,766 | -279,416 | 0.25 | 0.19 | -0.06 | sell |
| Artal Group S.A. | 1,390,477 | 1,066,064 | -324,413 | 1.66 | 1.22 | -0.44 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,059,633 | 735,088 | -324,545 | 0.78 | 0.56 | -0.21 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 632,133 | 201,048 | -431,085 | 0.06 | 0.02 | -0.04 | sell |
| First Light Asset Management, LLC | 1,690,177 | 1,200,508 | -489,669 | 6.06 | 4.71 | -1.34 | sell |
| Paradigm Biocapital Advisors LP | 3,124,749 | 2,513,302 | -611,447 | 5.15 | 4.31 | -0.84 | sell |
| T. Rowe Price Investment Management, Inc. | 2,654,729 | 1,347,210 | -1,307,519 | 0.08 | 0.04 | -0.04 | sell |