| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 778,398 | 1,998,161 | +1,219,763 | 0.07 | 0.14 | +0.06 | buy |
| CITADEL ADVISORS LLC | 38,551 | 653,635 | +615,084 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,112,360 | 5,590,504 | +478,144 | 0.02 | 0.02 | -0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 467,000 | +467,000 | 0.00 | 0.19 | +0.19 | buy |
| GOLDMAN SACHS GROUP INC | 499,594 | 900,887 | +401,293 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 1,946,168 | 2,343,553 | +397,385 | 3.00 | 2.88 | -0.13 | buy |
| MILLENNIUM MANAGEMENT LLC | 6,688 | 357,677 | +350,989 | 0.00 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 0 | 298,123 | +298,123 | 0.00 | 2.09 | +2.09 | buy |
| BAKER BROS. ADVISORS LP | 0 | 280,000 | +280,000 | 0.00 | 0.08 | +0.08 | buy |
| Novo Holdings A/S | 1,275,000 | 1,550,000 | +275,000 | 3.25 | 3.15 | -0.11 | buy |
| BANK OF AMERICA CORP /DE/ | 304,926 | 573,282 | +268,356 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 514,684 | 760,022 | +245,338 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 488,911 | 693,869 | +204,958 | 0.10 | 0.12 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,239,902 | 6,400,025 | +160,123 | 2.02 | 1.47 | -0.54 | buy |
| DIMENSIONAL FUND ADVISORS LP | 19,723 | 175,257 | +155,534 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,047,015 | 1,200,477 | +153,462 | 0.04 | 0.04 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 999,000 | 1,149,000 | +150,000 | 0.80 | 0.83 | +0.03 | buy |
| ROYAL BANK OF CANADA | 26,736 | 172,479 | +145,743 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 719,578 | 848,638 | +129,060 | 0.01 | 0.01 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 19,192 | 147,923 | +128,731 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 165,911 | 292,047 | +126,136 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 103,296 | +103,296 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 610,839 | 712,719 | +101,880 | 0.05 | 0.05 | -0.00 | buy |
| FMR LLC | 14,031,269 | 14,125,999 | +94,730 | 0.03 | 0.02 | -0.01 | buy |
| Aberdeen Group plc | 208,059 | 280,347 | +72,288 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 26,458 | 95,333 | +68,875 | 0.01 | 0.02 | +0.01 | buy |
| Nuveen, LLC | 456,633 | 524,951 | +68,318 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 265,495 | 331,957 | +66,462 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 123,982 | 190,373 | +66,391 | 0.05 | 0.05 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 77,461 | 140,978 | +63,517 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 6,300 | 67,300 | +61,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 52,779 | +52,779 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 920,020 | 970,810 | +50,790 | 0.29 | 0.25 | -0.04 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,605,098 | 4,646,098 | +41,000 | 0.83 | 0.61 | -0.22 | buy |
| XTX Topco Ltd | 0 | 34,013 | +34,013 | 0.00 | 0.04 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 205,054 | 238,610 | +33,556 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 146,274 | 176,517 | +30,243 | 0.08 | 0.07 | -0.00 | buy |
| Pier Capital, LLC | 113,412 | 142,611 | +29,199 | 0.64 | 0.63 | -0.01 | buy |
| AlphaQuest LLC | 0 | 27,795 | +27,795 | 0.00 | 0.08 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 174,694 | 202,482 | +27,788 | 0.01 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 689,265 | 716,172 | +26,907 | 0.02 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,190,932 | 2,213,325 | +22,393 | 0.01 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,793 | 154,980 | +20,187 | 0.00 | 0.00 | -0.00 | buy |
| Hood River Capital Management LLC | 872,635 | 888,470 | +15,835 | 0.50 | 0.36 | -0.14 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 14,741 | +14,741 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 753,527 | 766,228 | +12,701 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 8,998 | 21,456 | +12,458 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 12,434 | +12,434 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 533 | 12,768 | +12,235 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 51,295 | 62,700 | +11,405 | 1.54 | 1.49 | -0.05 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 251,331 | 261,531 | +10,200 | 0.01 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 63,940 | 73,412 | +9,472 | 0.25 | 0.24 | -0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 9,433 | +9,433 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 9,164 | +9,164 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 88,627 | 97,532 | +8,905 | 0.00 | 0.00 | -0.00 | buy |
| First Light Asset Management, LLC | 855,419 | 864,136 | +8,717 | 3.28 | 3.22 | -0.05 | buy |
| Invesco Ltd. | 69,959 | 78,140 | +8,181 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,990 | +7,990 | 0.00 | 0.07 | +0.07 | buy |
| Point72 Hong Kong Ltd | 0 | 7,790 | +7,790 | 0.00 | 0.02 | +0.02 | buy |
| ALTFEST L J & CO INC | 0 | 7,453 | +7,453 | 0.00 | 0.03 | +0.03 | buy |
| Quantinno Capital Management LP | 0 | 7,300 | +7,300 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 161,800 | 168,800 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| State of New Jersey Common Pension Fund D | 55,878 | 62,552 | +6,674 | 0.01 | 0.01 | -0.00 | buy |
| Fiera Capital Corp | 438,337 | 444,330 | +5,993 | 0.05 | 0.04 | -0.01 | buy |
| SEI INVESTMENTS CO | 54,714 | 60,180 | +5,466 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,959 | 18,328 | +5,369 | 0.04 | 0.05 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,468 | 15,755 | +5,287 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 174 | 5,341 | +5,167 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 5,150 | +5,150 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 315,659 | 320,545 | +4,886 | 0.00 | 0.00 | -0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 3,481 | +3,481 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 131,950 | 135,307 | +3,357 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 137,918 | 140,918 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 16,000 | 18,800 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 7,431 | 10,211 | +2,780 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 21,800 | 24,500 | +2,700 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,247 | 5,532 | +2,285 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 23,899 | 25,796 | +1,897 | 0.01 | 0.00 | -0.00 | buy |
| Penserra Capital Management LLC | 0 | 1,676 | +1,676 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 6,320 | 7,985 | +1,665 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,692 | 16,081 | +1,389 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 1,096 | 2,478 | +1,382 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 344,579 | 345,928 | +1,349 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,442 | 23,781 | +1,339 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 90 | 1,328 | +1,238 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 0 | 1,055 | +1,055 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 63,555 | 64,587 | +1,032 | 0.01 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,679 | 20,688 | +1,009 | 0.01 | 0.01 | -0.00 | buy |
| NATIXIS ADVISORS, LLC | 46,509 | 47,115 | +606 | 0.00 | 0.00 | -0.00 | buy |
| ASSETMARK, INC | 18,064 | 18,667 | +603 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 9,545 | 10,131 | +586 | 0.02 | 0.01 | -0.00 | buy |
| FIDUCIARY TRUST CO | 6,895 | 7,420 | +525 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,114 | 3,619 | +505 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 74,997 | 75,484 | +487 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 18 | 482 | +464 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 260 | +260 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 245 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 177 | 368 | +191 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 176 | +176 | 0.00 | 0.00 | +0.00 | buy |