| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,946,168 | 2,343,553 | +397,385 | 3.00 | 2.88 | -0.13 | buy |
| Novo Holdings A/S | 1,275,000 | 1,550,000 | +275,000 | 3.25 | 3.15 | -0.11 | buy |
| Candriam S.C.A. | 488,911 | 693,869 | +204,958 | 0.10 | 0.12 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,239,902 | 6,400,025 | +160,123 | 2.02 | 1.47 | -0.54 | buy |
| ORBIMED ADVISORS LLC | 999,000 | 1,149,000 | +150,000 | 0.80 | 0.83 | +0.03 | buy |
| Aberdeen Group plc | 208,059 | 280,347 | +72,288 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 920,020 | 970,810 | +50,790 | 0.29 | 0.25 | -0.04 | buy |
| SEGALL BRYANT & HAMILL, LLC | 146,274 | 176,517 | +30,243 | 0.08 | 0.07 | -0.00 | buy |
| Pier Capital, LLC | 113,412 | 142,611 | +29,199 | 0.64 | 0.63 | -0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 689,265 | 716,172 | +26,907 | 0.02 | 0.01 | -0.00 | buy |
| Hood River Capital Management LLC | 872,635 | 888,470 | +15,835 | 0.50 | 0.36 | -0.14 | buy |
| Exome Asset Management LLC | 51,295 | 62,700 | +11,405 | 1.54 | 1.49 | -0.05 | buy |
| Parkman Healthcare Partners LLC | 63,940 | 73,412 | +9,472 | 0.25 | 0.24 | -0.01 | buy |
| First Light Asset Management, LLC | 855,419 | 864,136 | +8,717 | 3.28 | 3.22 | -0.05 | buy |
| Fiera Capital Corp | 438,337 | 444,330 | +5,993 | 0.05 | 0.04 | -0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,959 | 18,328 | +5,369 | 0.03 | 0.05 | +0.02 | buy |
| DnB Asset Management AS | 7,431 | 10,211 | +2,780 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 9,545 | 10,131 | +586 | 0.02 | 0.01 | -0.00 | buy |
| FIDUCIARY TRUST CO | 6,895 | 7,420 | +525 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 18,664 | 18,815 | +151 | 0.06 | 0.05 | -0.01 | buy |
| M&G Plc | 281,822 | 281,896 | +74 | 0.05 | 0.05 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 64 | 98 | +34 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 72 | 92 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 2,953 | 2,923 | -30 | 0.03 | 0.03 | +0.00 | sell |
| NEOS Investment Management LLC | 58,807 | 58,101 | -706 | 0.04 | 0.02 | -0.02 | sell |
| TEMA ETFS LLC | 58,807 | 58,101 | -706 | 0.59 | 0.44 | -0.15 | sell |
| Lewis Asset Management, LLC | 20,000 | 18,400 | -1,600 | 0.55 | 0.25 | -0.31 | sell |
| MOODY ALDRICH PARTNERS LLC | 139,905 | 137,796 | -2,109 | 0.98 | 0.77 | -0.22 | sell |
| PROFUND ADVISORS LLC | 21,917 | 19,697 | -2,220 | 0.03 | 0.02 | -0.01 | sell |
| Kestra Investment Management, LLC | 2,839 | 293 | -2,546 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 177,958 | 143,000 | -34,958 | 1.67 | 1.04 | -0.64 | sell |
| Fisher Asset Management, LLC | 773,347 | 737,084 | -36,263 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 523,431 | 433,431 | -90,000 | 2.16 | 2.39 | +0.23 | sell |
| JENNISON ASSOCIATES LLC | 2,119,767 | 1,987,118 | -132,649 | 0.05 | 0.03 | -0.02 | sell |
| Cormorant Asset Management, LP | 600,000 | 400,000 | -200,000 | 1.51 | 0.86 | -0.66 | sell |
| MPM BioImpact LLC | 631,964 | 428,975 | -202,989 | 3.64 | 2.14 | -1.51 | sell |