| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 15,759,799 | 15,840,219 | +80,420 | 0.03 | 0.03 | -0.00 | buy |
| BlackRock, Inc. | 8,478,815 | 9,758,938 | +1,280,123 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 8,338,098 | 8,989,098 | +651,000 | 1.80 | 1.97 | +0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,157,204 | 7,131,084 | -1,026,120 | 0.06 | 0.05 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,395,922 | 6,463,551 | +67,629 | 1.71 | 1.40 | -0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,355,496 | 6,212,681 | +857,185 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,480,763 | 2,727,633 | +246,870 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 2,403,046 | 2,689,350 | +286,304 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 3,280,000 | 2,620,000 | -660,000 | 2.84 | 2.06 | -0.77 | sell |
| BAKER BROS. ADVISORS LP | 2,351,465 | 2,351,465 | 0 | 0.49 | 0.44 | -0.05 | hold |
| Polar Capital Holdings Plc | 0 | 2,274,411 | +2,274,411 | 0.00 | 0.24 | +0.24 | buy |
| Pictet Asset Management Holding SA | 1,884,281 | 2,075,375 | +191,094 | 0.07 | 0.07 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,940,622 | 2,010,288 | +69,666 | 0.05 | 0.05 | +0.00 | buy |
| GW&K Investment Management, LLC | 1,618,686 | 1,731,140 | +112,454 | 0.52 | 0.51 | -0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,716,445 | 1,678,490 | -37,955 | 0.07 | 0.06 | -0.01 | sell |
| Siren, L.L.C. | 1,903,636 | 1,420,788 | -482,848 | 1.92 | 1.08 | -0.84 | sell |
| JPMORGAN CHASE & CO | 1,324,668 | 1,365,030 | +40,362 | 0.00 | 0.00 | -0.00 | buy |
| First Light Asset Management, LLC | 1,089,670 | 1,360,866 | +271,196 | 3.55 | 3.10 | -0.45 | buy |
| MORGAN STANLEY | 919,686 | 1,338,531 | +418,845 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 716,125 | 1,333,071 | +616,946 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,550,000 | 1,320,000 | -230,000 | 4.56 | 2.87 | -1.69 | sell |
| DIMENSIONAL FUND ADVISORS LP | 852,258 | 1,270,531 | +418,273 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,052,858 | 1,262,562 | +209,704 | 0.02 | 0.02 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,139,331 | 1,222,080 | +82,749 | 2.49 | 2.15 | -0.34 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,043,879 | 1,186,279 | +142,400 | 1.03 | 0.93 | -0.10 | buy |
| MARSHALL WACE, LLP | 684,108 | 1,126,639 | +442,531 | 0.03 | 0.04 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 628,155 | 1,104,998 | +476,843 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 999,000 | 999,000 | 0 | 0.79 | 0.71 | -0.08 | hold |
| NORTHERN TRUST CORP | 841,301 | 974,781 | +133,480 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 907,412 | 968,996 | +61,584 | 0.33 | 0.26 | -0.07 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 877,643 | +877,643 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 833,418 | 877,643 | +44,225 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 820,395 | 820,395 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Candriam S.C.A. | 830,961 | 819,032 | -11,929 | 0.16 | 0.14 | -0.02 | sell |
| Fisher Asset Management, LLC | 762,702 | 741,553 | -21,149 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 571,899 | 561,165 | -10,734 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 551,464 | 555,381 | +3,917 | 0.01 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 798,334 | 497,205 | -301,129 | 0.01 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 382,363 | 480,504 | +98,141 | 0.01 | 0.01 | +0.00 | buy |
| Impax Asset Management Group plc | 350,000 | 435,000 | +85,000 | 0.09 | 0.11 | +0.02 | buy |
| Bank of New York Mellon Corp | 358,719 | 393,688 | +34,969 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 350,000 | 374,666 | +24,666 | 2.08 | 2.42 | +0.33 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 425,616 | 373,910 | -51,706 | 0.03 | 0.02 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 365,714 | +365,714 | 0.00 | 0.24 | +0.24 | buy |
| BRAUN STACEY ASSOCIATES INC | 324,808 | 348,143 | +23,335 | 0.39 | 0.37 | -0.02 | buy |
| Fiera Capital Corp | 589,654 | 338,841 | -250,813 | 0.07 | 0.05 | -0.03 | sell |
| DEUTSCHE BANK AG\ | 257,525 | 283,727 | +26,202 | 0.00 | 0.00 | -0.00 | buy |
| Foresite Capital Management VI LLC | 212,010 | 212,010 | 0 | 1.67 | 1.23 | -0.44 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 230,128 | 202,395 | -27,733 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 195,701 | 196,318 | +617 | 0.40 | 0.36 | -0.04 | buy |
| TD ASSET MANAGEMENT INC | 234,892 | 191,142 | -43,750 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 176,500 | 183,800 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 180,112 | 183,199 | +3,087 | 0.07 | 0.08 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 904,672 | 161,861 | -742,811 | 0.02 | 0.00 | -0.02 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 163,633 | 156,738 | -6,895 | 0.04 | 0.04 | -0.00 | sell |
| Foresite Capital Management IV, LLC | 0 | 150,000 | +150,000 | 0.00 | 1.93 | +1.93 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 141,618 | 147,218 | +5,600 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 150,659 | 146,216 | -4,443 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 183,438 | 146,077 | -37,361 | 1.20 | 0.98 | -0.22 | sell |
| CITADEL ADVISORS LLC | 317,934 | 138,329 | -179,605 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 73,652 | 137,576 | +63,924 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 170,949 | 131,680 | -39,269 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 118,420 | 129,908 | +11,488 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 147,680 | 125,948 | -21,732 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 250,000 | 125,000 | -125,000 | 0.46 | 0.24 | -0.22 | sell |
| BARCLAYS PLC | 106,734 | 122,451 | +15,717 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 133,466 | 116,460 | -17,006 | 0.00 | 0.00 | -0.00 | sell |
| SECTOR GAMMA AS | 94,195 | 114,628 | +20,433 | 0.81 | 0.93 | +0.12 | buy |
| XTX Topco Ltd | 97,166 | 111,292 | +14,126 | 0.06 | 0.05 | -0.01 | buy |
| ALPS ADVISORS INC | 85,232 | 106,409 | +21,177 | 0.01 | 0.02 | +0.00 | buy |
| FEDERATED HERMES, INC. | 16,248 | 105,756 | +89,508 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 105,563 | 102,229 | -3,334 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.18 | 0.14 | -0.04 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 99,364 | 93,112 | -6,252 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 87,299 | 87,299 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AWM Investment Company, Inc. | 100,000 | 85,000 | -15,000 | 0.40 | 0.28 | -0.13 | sell |
| SEI INVESTMENTS CO | 73,961 | 83,225 | +9,264 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 74,355 | 77,569 | +3,214 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.16 | 0.14 | -0.02 | hold |
| ALGERT GLOBAL LLC | 97,802 | 72,532 | -25,270 | 0.05 | 0.03 | -0.02 | sell |
| ExodusPoint Capital Management, LP | 0 | 70,882 | +70,882 | 0.00 | 0.02 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 75,424 | 67,004 | -8,420 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 25,087 | 66,603 | +41,516 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 51,365 | 63,352 | +11,987 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 107,875 | 63,147 | -44,728 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 47,580 | 61,043 | +13,463 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 54,326 | 60,361 | +6,035 | 0.01 | 0.01 | +0.00 | buy |
| Swedbank AB | 0 | 59,600 | +59,600 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 58,388 | +58,388 | 0.00 | 0.06 | +0.06 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 65,232 | 55,265 | -9,967 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 16,000 | 51,400 | +35,400 | 0.01 | 0.02 | +0.01 | buy |
| ROYAL BANK OF CANADA | 49,778 | 50,880 | +1,102 | 0.00 | 0.00 | -0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| Vestmark Advisory Solutions, Inc. | 48,724 | 48,724 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,847 | 47,762 | +1,915 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 46,381 | +46,381 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 45,269 | 45,334 | +65 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 45,192 | 43,632 | -1,560 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 53,637 | 40,476 | -13,161 | 0.00 | 0.00 | -0.00 | sell |
| HighMark Wealth Management LLC | 20,495 | 38,595 | +18,100 | 0.30 | 0.48 | +0.18 | buy |