| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 461,497 | 1,433,691 | +972,194 | 0.01 | 0.04 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 1,395,002 | 2,178,737 | +783,735 | 2.03 | 4.42 | +2.39 | buy |
| T. Rowe Price Investment Management, Inc. | 964,005 | 1,640,692 | +676,687 | 0.01 | 0.03 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 434,768 | 1,018,782 | +584,014 | 0.13 | 0.54 | +0.41 | buy |
| Ikarian Capital, LLC | 475,000 | 792,920 | +317,920 | 3.02 | 8.75 | +5.74 | buy |
| EcoR1 Capital, LLC | 1,330,263 | 1,530,263 | +200,000 | 0.63 | 1.55 | +0.92 | buy |
| Saturn V Capital Management LP | 938,677 | 1,126,579 | +187,902 | 9.38 | 14.02 | +4.64 | buy |
| Frazier Life Sciences Management, L.P. | 1,414,823 | 1,589,931 | +175,108 | 1.52 | 3.14 | +1.62 | buy |
| Altium Capital Management LLC | 135,000 | 262,000 | +127,000 | 1.90 | 4.51 | +2.61 | buy |
| Campbell & CO Investment Adviser LLC | 21,594 | 63,917 | +42,323 | 0.07 | 0.23 | +0.16 | buy |
| First Light Asset Management, LLC | 1,557,222 | 1,583,329 | +26,107 | 2.20 | 4.47 | +2.27 | buy |
| Hennion & Walsh Asset Management, Inc. | 18,236 | 34,563 | +16,327 | 0.02 | 0.07 | +0.05 | buy |
| PROFUND ADVISORS LLC | 25,596 | 33,826 | +8,230 | 0.02 | 0.06 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 708 | 1,403 | +695 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 39,710 | 40,328 | +618 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,333 | 4,849 | -484 | 0.06 | 0.09 | +0.03 | sell |
| West Tower Group, LLC | 792 | 140 | -652 | 0.01 | 0.00 | -0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 48,180 | 44,377 | -3,803 | 0.02 | 0.03 | +0.01 | sell |
| MBB PUBLIC MARKETS I LLC | 12,802 | 8,702 | -4,100 | 0.01 | 0.02 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 641,345 | 633,364 | -7,981 | 0.04 | 0.06 | +0.02 | sell |
| BIT Capital GmbH | 45,359 | 23,082 | -22,277 | 0.10 | 0.09 | -0.00 | sell |
| GW&K Investment Management, LLC | 585,740 | 482,942 | -102,798 | 0.10 | 0.14 | +0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,298,088 | 5,132,287 | -165,801 | 1.21 | 1.98 | +0.78 | sell |
| 5AM Venture Management, LLC | 862,286 | 462,286 | -400,000 | 3.87 | 3.96 | +0.09 | sell |
| Opaleye Management Inc. | 845,000 | 370,000 | -475,000 | 3.64 | 3.58 | -0.06 | sell |
| PERCEPTIVE ADVISORS LLC | 1,946,937 | 1,263,732 | -683,205 | 1.02 | 1.26 | +0.24 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,305,558 | 1,275,552 | -1,030,006 | 4.28 | 4.24 | -0.04 | sell |
| ORBIMED ADVISORS LLC | 3,950,796 | 2,896,074 | -1,054,722 | 1.30 | 1.85 | +0.55 | sell |