| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 4,514,478 | 6,287,655 | +1,773,177 | 0.00 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 497,000 | 1,162,000 | +665,000 | 0.13 | 0.33 | +0.19 | buy |
| Pictet Asset Management Holding SA | 300,868 | 908,149 | +607,281 | 0.02 | 0.05 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,406,456 | 4,944,757 | +538,301 | 0.02 | 0.03 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 861,422 | 1,390,110 | +528,688 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 410,342 | 834,912 | +424,570 | 0.38 | 0.69 | +0.31 | buy |
| AMERICAN CENTURY COMPANIES INC | 11,178 | 386,886 | +375,708 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 4,096,795 | 4,455,770 | +358,975 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 377,663 | 732,892 | +355,229 | 0.15 | 0.32 | +0.17 | buy |
| Vestal Point Capital, LP | 0 | 205,000 | +205,000 | 0.00 | 0.83 | +0.83 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,678,387 | 1,848,133 | +169,746 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 236,773 | 388,638 | +151,865 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 24,798 | 168,493 | +143,695 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 649,190 | 787,028 | +137,838 | 0.01 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 4,155,375 | 4,288,120 | +132,745 | 5.69 | 7.50 | +1.81 | buy |
| NORTHERN TRUST CORP | 606,037 | 730,516 | +124,479 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 226,687 | 343,344 | +116,657 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 118,354 | 207,712 | +89,358 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 181,599 | 255,300 | +73,701 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 73,340 | +73,340 | 0.00 | 0.15 | +0.15 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 13,205 | 77,709 | +64,504 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 597,049 | 655,418 | +58,369 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 49,445 | +49,445 | 0.00 | 0.14 | +0.14 | buy |
| MACQUARIE GROUP LTD | 0 | 45,612 | +45,612 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 53,012 | 93,860 | +40,848 | 0.25 | 0.44 | +0.19 | buy |
| Trexquant Investment LP | 22,538 | 62,679 | +40,141 | 0.02 | 0.04 | +0.03 | buy |
| Fisher Asset Management, LLC | 444,670 | 482,099 | +37,429 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 31,070 | 64,825 | +33,755 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 39,566 | 65,689 | +26,123 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,812,923 | 2,838,484 | +25,561 | 0.01 | 0.01 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 83,380 | 108,575 | +25,195 | 0.90 | 1.41 | +0.51 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 22,348 | +22,348 | 0.00 | 0.01 | +0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 22,074 | +22,074 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 36,973 | 56,156 | +19,183 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,860 | 49,815 | +13,955 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 74,850 | 88,425 | +13,575 | 0.68 | 0.76 | +0.08 | buy |
| JENNISON ASSOCIATES LLC | 2,780,144 | 2,793,614 | +13,470 | 0.08 | 0.09 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 196,961 | 210,391 | +13,430 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 121,879 | 135,134 | +13,255 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 203,889 | 216,117 | +12,228 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,942 | 20,942 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 72,920 | 84,891 | +11,971 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 32,476 | 44,346 | +11,870 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 260,980 | 271,747 | +10,767 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 119,880 | 129,592 | +9,712 | 0.01 | 0.01 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 8,640 | +8,640 | 0.00 | 0.10 | +0.10 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,390 | 46,444 | +8,054 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 27,004 | 34,646 | +7,642 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 12,997 | 19,808 | +6,811 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 6,727 | +6,727 | 0.00 | 0.04 | +0.04 | buy |
| Valence8 US LP | 0 | 6,684 | +6,684 | 0.00 | 0.15 | +0.15 | buy |
| Allianz Asset Management GmbH | 7,900 | 14,200 | +6,300 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,265 | 15,393 | +6,128 | 0.06 | 0.09 | +0.03 | buy |
| ProShare Advisors LLC | 13,704 | 19,434 | +5,730 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 204,998 | 210,122 | +5,124 | 0.01 | 0.01 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 4,982 | +4,982 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 60,416 | 65,394 | +4,978 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 0 | 4,909 | +4,909 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,717 | +4,717 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 4,375 | +4,375 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 0 | 4,216 | +4,216 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 0 | 4,155 | +4,155 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 53,570 | 57,389 | +3,819 | 0.10 | 0.09 | -0.01 | buy |
| ROYAL BANK OF CANADA | 31,666 | 35,083 | +3,417 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,513,302 | 2,516,686 | +3,384 | 4.31 | 4.50 | +0.19 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 131,063 | 134,087 | +3,024 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 16,400 | 19,000 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 51,791 | 54,326 | +2,535 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,520 | +2,520 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14,547 | 16,811 | +2,264 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 15,117 | 17,147 | +2,030 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 1,786 | +1,786 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 68,758 | 70,496 | +1,738 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 1,644 | +1,644 | 0.00 | 0.05 | +0.05 | buy |
| ALGERT GLOBAL LLC | 41,707 | 42,777 | +1,070 | 0.06 | 0.06 | -0.00 | buy |
| Advisors Asset Management, Inc. | 1,798 | 2,806 | +1,008 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 285,062 | 285,956 | +894 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 4,699 | 5,469 | +770 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 18,543 | 19,301 | +758 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 616,227 | 616,837 | +610 | 0.05 | 0.06 | +0.00 | buy |
| Swiss National Bank | 130,300 | 130,900 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,354 | 2,895 | +541 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 20,128 | 20,633 | +505 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 7,126 | 7,568 | +442 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 725 | 1,158 | +433 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 7 | 419 | +412 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 1,786 | 2,193 | +407 | 0.00 | 0.00 | +0.00 | buy |
| Raleigh Capital Management Inc. | 0 | 400 | +400 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 11,115 | 11,488 | +373 | 0.00 | 0.00 | +0.00 | buy |
| Asset Dedication, LLC | 0 | 305 | +305 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,623 | 7,883 | +260 | 0.01 | 0.01 | +0.00 | buy |
| XPONANCE, INC. | 4,930 | 5,116 | +186 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 240 | 361 | +121 | 0.00 | 0.00 | +0.00 | buy |
| Snowden Capital Advisors LLC | 5,034 | 5,143 | +109 | 0.01 | 0.01 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 85 | +55 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 65 | 118 | +53 | 0.00 | 0.00 | +0.00 | buy |
| WOLFF WIESE MAGANA LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 11 | 56 | +45 | 0.00 | 0.00 | +0.00 | buy |