| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Hood River Capital Management LLC | 410,342 | 834,912 | +424,570 | 0.38 | 0.69 | +0.31 | buy |
| GW&K Investment Management, LLC | 377,663 | 732,892 | +355,229 | 0.15 | 0.32 | +0.17 | buy |
| EcoR1 Capital, LLC | 4,155,375 | 4,288,120 | +132,745 | 5.69 | 7.50 | +1.81 | buy |
| Nicholas Investment Partners, LP | 53,012 | 93,860 | +40,848 | 0.25 | 0.44 | +0.19 | buy |
| Fisher Asset Management, LLC | 444,670 | 482,099 | +37,429 | 0.01 | 0.01 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 83,380 | 108,575 | +25,195 | 0.90 | 1.41 | +0.51 | buy |
| ADAR1 Capital Management, LLC | 74,850 | 88,425 | +13,575 | 0.68 | 0.76 | +0.08 | buy |
| JENNISON ASSOCIATES LLC | 2,780,144 | 2,793,614 | +13,470 | 0.08 | 0.09 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 9,265 | 15,393 | +6,128 | 0.06 | 0.09 | +0.03 | buy |
| NEOS Investment Management LLC | 53,570 | 57,389 | +3,819 | 0.10 | 0.09 | -0.01 | buy |
| Paradigm Biocapital Advisors LP | 2,513,302 | 2,516,686 | +3,384 | 4.31 | 4.50 | +0.19 | buy |
| Informed Momentum Co LLC | 57,179 | 57,216 | +37 | 0.42 | 0.44 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 1,931 | 1,962 | +31 | 0.04 | 0.05 | +0.00 | buy |
| Pier Capital, LLC | 108,545 | 108,361 | -184 | 0.72 | 0.78 | +0.06 | sell |
| Lewis Asset Management, LLC | 12,395 | 12,175 | -220 | 0.42 | 0.45 | +0.03 | sell |
| GILDER GAGNON HOWE & CO LLC | 12,836 | 12,615 | -221 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 41,344 | 40,835 | -509 | 0.10 | 0.10 | +0.00 | sell |
| E Fund Management Co., Ltd. | 6,813 | 6,262 | -551 | 0.02 | 0.02 | -0.00 | sell |
| Calamos Advisors LLC | 42,336 | 41,558 | -778 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 61,525 | 60,743 | -782 | 0.02 | 0.02 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 135,141 | 131,700 | -3,441 | 5.10 | 5.45 | +0.35 | sell |
| HighVista Strategies LLC | 35,237 | 28,911 | -6,326 | 0.58 | 0.51 | -0.07 | sell |
| MOODY ALDRICH PARTNERS LLC | 150,183 | 139,130 | -11,053 | 1.31 | 1.29 | -0.02 | sell |
| Fiera Capital Corp | 480,409 | 466,075 | -14,334 | 0.07 | 0.07 | +0.00 | sell |
| First Turn Management, LLC | 369,302 | 353,376 | -15,926 | 2.69 | 2.86 | +0.17 | sell |
| Aberdeen Group plc | 66,196 | 35,467 | -30,729 | 0.01 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 557,184 | 525,845 | -31,339 | 3.88 | 4.03 | +0.15 | sell |
| Artia Global Partners LP | 85,765 | 45,765 | -40,000 | 0.99 | 0.66 | -0.32 | sell |
| BNP Paribas Asset Management Holding S.A. | 546,234 | 491,381 | -54,853 | 0.06 | 0.06 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 141,375 | 77,623 | -63,752 | 0.86 | 0.51 | -0.36 | sell |
| Integral Health Asset Management, LLC | 400,000 | 300,000 | -100,000 | 1.78 | 1.80 | +0.02 | sell |
| Affinity Asset Advisors, LLC | 515,000 | 400,000 | -115,000 | 3.63 | 3.17 | -0.46 | sell |
| LORD, ABBETT & CO. LLC | 887,921 | 746,118 | -141,803 | 0.13 | 0.12 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 201,048 | 40,000 | -161,048 | 0.02 | 0.00 | -0.01 | sell |
| Ikarian Capital, LLC | 588,818 | 426,913 | -161,905 | 8.23 | 6.77 | -1.45 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,112,173 | 5,885,248 | -226,925 | 2.65 | 2.58 | -0.07 | sell |
| ORBIMED ADVISORS LLC | 1,280,800 | 1,050,055 | -230,745 | 1.14 | 0.98 | -0.16 | sell |
| Cormorant Asset Management, LP | 1,350,000 | 1,100,000 | -250,000 | 3.49 | 2.98 | -0.51 | sell |
| First Light Asset Management, LLC | 1,200,508 | 943,611 | -256,897 | 4.71 | 4.01 | -0.70 | sell |
| T. Rowe Price Investment Management, Inc. | 1,347,210 | 1,068,532 | -278,678 | 0.04 | 0.03 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 551,095 | 213,815 | -337,280 | 7.26 | 3.28 | -3.98 | sell |
| Saturn V Capital Management LP | 479,681 | 109,567 | -370,114 | 8.12 | 2.00 | -6.12 | sell |
| PERCEPTIVE ADVISORS LLC | 1,476,203 | 724,698 | -751,505 | 1.59 | 0.78 | -0.81 | sell |