| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,125,999 | 14,187,498 | +61,499 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 9,256,132 | 9,170,129 | -86,003 | 0.00 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,807,308 | 8,381,991 | +2,574,683 | 0.03 | 0.06 | +0.03 | buy |
| BlackRock, Inc. | 7,418,715 | 7,586,597 | +167,882 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,400,025 | 6,481,613 | +81,588 | 1.47 | 1.93 | +0.46 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 4,646,098 | 5,770,098 | +1,124,000 | 0.61 | 1.36 | +0.75 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,590,504 | 5,306,248 | -284,256 | 0.02 | 0.02 | +0.01 | sell |
| EcoR1 Capital, LLC | 4,288,120 | 4,288,120 | 0 | 7.31 | 8.57 | +1.26 | hold |
| JANUS HENDERSON GROUP PLC | 3,410,320 | 3,858,791 | +448,471 | 0.05 | 0.07 | +0.03 | buy |
| Paradigm Biocapital Advisors LP | 2,343,553 | 2,550,774 | +207,221 | 2.88 | 3.14 | +0.27 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,213,325 | 2,278,830 | +65,505 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,224,306 | 2,207,707 | -1,016,599 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 1,987,118 | 2,044,734 | +57,616 | 0.03 | 0.05 | +0.02 | buy |
| Point72 Asset Management, L.P. | 1,998,161 | 2,003,333 | +5,172 | 0.14 | 0.18 | +0.05 | buy |
| Siren, L.L.C. | 1,688,611 | 1,688,611 | 0 | 2.51 | 2.75 | +0.24 | hold |
| Novo Holdings A/S | 1,550,000 | 1,625,000 | +75,000 | 3.15 | 4.36 | +1.22 | buy |
| Pictet Asset Management Holding SA | 1,200,477 | 1,465,262 | +264,785 | 0.04 | 0.06 | +0.02 | buy |
| JPMORGAN CHASE & CO | 331,957 | 1,258,722 | +926,765 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 848,638 | 1,133,535 | +284,897 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 1,149,000 | 1,099,000 | -50,000 | 0.83 | 1.10 | +0.27 | sell |
| First Light Asset Management, LLC | 864,136 | 941,516 | +77,380 | 3.22 | 3.70 | +0.47 | buy |
| CITADEL ADVISORS LLC | 653,635 | 884,507 | +230,872 | 0.02 | 0.03 | +0.01 | buy |
| Hood River Capital Management LLC | 888,470 | 883,004 | -5,466 | 0.36 | 0.43 | +0.08 | sell |
| RTW INVESTMENTS, LP | 467,000 | 872,387 | +405,387 | 0.19 | 0.45 | +0.26 | buy |
| GW&K Investment Management, LLC | 970,810 | 850,546 | -120,264 | 0.25 | 0.31 | +0.06 | sell |
| BNP Paribas Asset Management Holding S.A. | 712,719 | 834,031 | +121,312 | 0.05 | 0.09 | +0.04 | buy |
| NORTHERN TRUST CORP | 784,213 | 809,888 | +25,675 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 766,228 | 778,652 | +12,424 | 0.00 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 737,084 | 758,357 | +21,273 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 1,500,000 | 750,000 | -750,000 | 2.27 | 1.42 | -0.85 | sell |
| Candriam S.C.A. | 693,869 | 745,094 | +51,225 | 0.12 | 0.16 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 900,887 | 713,130 | -187,757 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 760,022 | 682,134 | -77,888 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 238,610 | 614,816 | +376,206 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 573,282 | 601,042 | +27,760 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 524,951 | 544,754 | +19,803 | 0.00 | 0.01 | +0.00 | buy |
| Fiera Capital Corp | 444,330 | 435,425 | -8,905 | 0.04 | 0.06 | +0.02 | sell |
| UBS Group AG | 320,545 | 407,722 | +87,177 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 400,000 | 400,000 | 0 | 0.86 | 1.15 | +0.29 | hold |
| Bank of New York Mellon Corp | 345,928 | 399,634 | +53,706 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 341,705 | 387,925 | +46,220 | 0.02 | 0.03 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 175,257 | 377,802 | +202,545 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 280,347 | 339,949 | +59,602 | 0.01 | 0.02 | +0.01 | buy |
| Prosight Management, LP | 298,123 | 328,684 | +30,561 | 2.09 | 3.29 | +1.20 | buy |
| Ensign Peak Advisors, Inc | 315,564 | 295,008 | -20,556 | 0.02 | 0.02 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 280,000 | 280,000 | 0 | 0.08 | 0.08 | +0.01 | hold |
| Checkpoint Capital L.P. | 0 | 260,000 | +260,000 | 0.00 | 3.63 | +3.63 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,664 | 257,505 | +129,841 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 53,125 | 248,368 | +195,243 | 0.25 | 1.02 | +0.78 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 261,531 | 233,386 | -28,145 | 0.00 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 195,196 | 232,365 | +37,169 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 334,796 | 217,690 | -117,106 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 357,677 | 216,244 | -141,433 | 0.01 | 0.01 | -0.00 | sell |
| HSBC HOLDINGS PLC | 7,197 | 210,821 | +203,624 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 202,482 | 203,548 | +1,066 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 292,047 | 183,236 | -108,811 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 176,517 | 180,849 | +4,332 | 0.07 | 0.10 | +0.03 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 18,117 | 178,584 | +160,467 | 0.00 | 0.03 | +0.03 | buy |
| Sio Capital Management, LLC | 0 | 174,841 | +174,841 | 0.00 | 1.84 | +1.84 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 174,077 | +174,077 | 0.00 | 0.40 | +0.40 | buy |
| Swiss National Bank | 168,800 | 172,500 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 172,479 | 170,495 | -1,984 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 156,383 | 148,982 | -7,401 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 140,918 | 148,277 | +7,359 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 154,980 | 147,813 | -7,167 | 0.00 | 0.01 | +0.00 | sell |
| Decheng Capital LLC | 143,000 | 143,000 | 0 | 1.04 | 1.04 | +0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 141,000 | 141,000 | 0 | 7.66 | 13.64 | +5.98 | hold |
| RHUMBLINE ADVISERS | 135,307 | 131,522 | -3,785 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 433,431 | 130,902 | -302,529 | 4.12 | 1.10 | -3.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 137,796 | 115,543 | -22,253 | 0.77 | 0.91 | +0.15 | sell |
| AWM Investment Company, Inc. | 95,000 | 100,000 | +5,000 | 0.31 | 0.39 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 90,060 | 98,702 | +8,642 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 97,532 | 93,809 | -3,723 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 93,020 | 93,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 78,140 | 89,393 | +11,253 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 140,978 | 87,318 | -53,660 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,484 | 84,179 | +8,695 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 147,923 | 81,847 | -66,076 | 0.03 | 0.02 | -0.01 | sell |
| Pier Capital, LLC | 142,611 | 75,000 | -67,611 | 0.63 | 0.49 | -0.14 | sell |
| Affinity Asset Advisors, LLC | 152,252 | 75,000 | -77,252 | 0.65 | 0.29 | -0.36 | sell |
| Parkman Healthcare Partners LLC | 73,412 | 73,725 | +313 | 0.24 | 0.34 | +0.09 | buy |
| State of New Jersey Common Pension Fund D | 62,552 | 72,349 | +9,797 | 0.01 | 0.01 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 68,200 | +68,200 | 0.00 | 0.11 | +0.11 | buy |
| Neuberger Berman Group LLC | 0 | 67,148 | +67,148 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 716,172 | 60,584 | -655,588 | 0.01 | 0.00 | -0.01 | sell |
| SEI INVESTMENTS CO | 60,180 | 60,340 | +160 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,587 | 57,025 | -7,562 | 0.00 | 0.01 | +0.00 | sell |
| Phocas Financial Corp. | 0 | 54,015 | +54,015 | 0.00 | 0.29 | +0.29 | buy |
| MetLife Investment Management, LLC | 53,414 | 53,414 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TWO SIGMA ADVISERS, LP | 67,300 | 53,300 | -14,000 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 54,258 | 52,665 | -1,593 | 0.00 | 0.00 | +0.00 | sell |
| NATIXIS ADVISORS, LLC | 47,115 | 51,746 | +4,631 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.30 | +0.30 | buy |
| TWO SIGMA INVESTMENTS, LP | 52,779 | 49,699 | -3,080 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 50,524 | 47,415 | -3,109 | 0.01 | 0.01 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 53,995 | 42,009 | -11,986 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 28,469 | 40,572 | +12,103 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 48,957 | 34,694 | -14,263 | 0.00 | 0.00 | +0.00 | sell |
| Weiss Asset Management LP | 0 | 33,958 | +33,958 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 20,282 | 32,271 | +11,989 | 0.00 | 0.00 | +0.00 | buy |