| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 1,433,691 | 2,547,683 | +1,113,992 | 0.04 | 0.07 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 1,640,692 | 2,417,493 | +776,801 | 0.03 | 0.06 | +0.02 | buy |
| EcoR1 Capital, LLC | 1,530,263 | 2,012,517 | +482,254 | 1.54 | 1.86 | +0.32 | buy |
| First Light Asset Management, LLC | 1,583,329 | 1,987,772 | +404,443 | 4.47 | 5.69 | +1.22 | buy |
| Fisher Asset Management, LLC | 53,860 | 441,295 | +387,435 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 346,637 | 568,982 | +222,345 | 0.06 | 0.17 | +0.11 | buy |
| Paradigm Biocapital Advisors LP | 2,178,737 | 2,312,919 | +134,182 | 4.42 | 3.86 | -0.56 | buy |
| MBB PUBLIC MARKETS I LLC | 8,702 | 66,433 | +57,731 | 0.02 | 0.15 | +0.13 | buy |
| Lisanti Capital Growth, LLC | 49,980 | 100,245 | +50,265 | 0.23 | 0.84 | +0.61 | buy |
| Cormorant Asset Management, LP | 1,101,904 | 1,150,000 | +48,096 | 1.91 | 1.95 | +0.04 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,018,782 | 1,059,633 | +40,851 | 0.54 | 0.62 | +0.07 | buy |
| AWM Investment Company, Inc. | 15,000 | 50,000 | +35,000 | 0.07 | 0.23 | +0.17 | buy |
| BNP Paribas Asset Management Holding S.A. | 633,364 | 658,289 | +24,925 | 0.06 | 0.07 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 120,652 | +20,652 | 0.54 | 0.61 | +0.06 | buy |
| Zimmer Partners, LP | 15,000 | 28,700 | +13,700 | 0.01 | 0.04 | +0.03 | buy |
| Informed Momentum Co LLC | 94,189 | 105,005 | +10,816 | 0.54 | 0.66 | +0.12 | buy |
| Alyeska Investment Group, L.P. | 69,502 | 76,575 | +7,073 | 0.01 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,403 | 7,721 | +6,318 | 0.01 | 0.05 | +0.04 | buy |
| ALPS ADVISORS INC | 40,328 | 46,025 | +5,697 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,155 | 13,069 | +2,914 | 0.02 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 34,563 | 37,160 | +2,597 | 0.07 | 0.08 | +0.01 | buy |
| West Tower Group, LLC | 140 | 176 | +36 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 479,053 | 478,234 | -819 | 3.80 | 3.98 | +0.18 | sell |
| Sandia Investment Management LP | 5,000 | 2,990 | -2,010 | 0.04 | 0.07 | +0.03 | sell |
| VIRTUS ADVISERS, LLC | 4,849 | 2,654 | -2,195 | 0.09 | 0.06 | -0.03 | sell |
| Affinity Asset Advisors, LLC | 450,000 | 447,095 | -2,905 | 4.37 | 3.17 | -1.20 | sell |
| GW&K Investment Management, LLC | 482,942 | 479,063 | -3,879 | 0.14 | 0.16 | +0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 94,000 | 87,500 | -6,500 | 1.87 | 1.75 | -0.12 | sell |
| PERCEPTIVE ADVISORS LLC | 1,263,732 | 1,255,512 | -8,220 | 1.25 | 1.00 | -0.26 | sell |
| FORA Capital, LLC | 25,777 | 9,093 | -16,684 | 0.07 | 0.03 | -0.04 | sell |
| Opaleye Management Inc. | 370,000 | 307,500 | -62,500 | 3.58 | 2.91 | -0.67 | sell |
| Avidity Partners Management LP | 610,000 | 529,000 | -81,000 | 0.73 | 0.72 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,132,287 | 5,039,957 | -92,330 | 1.98 | 2.16 | +0.18 | sell |
| Ikarian Capital, LLC | 792,920 | 680,370 | -112,550 | 8.75 | 6.62 | -2.13 | sell |
| Altium Capital Management LLC | 262,000 | 65,000 | -197,000 | 4.51 | 1.59 | -2.91 | sell |
| Saturn V Capital Management LP | 1,126,579 | 787,132 | -339,447 | 14.02 | 10.72 | -3.30 | sell |
| Frazier Life Sciences Management, L.P. | 1,589,931 | 397,483 | -1,192,448 | 3.14 | 0.76 | -2.39 | sell |
| ORBIMED ADVISORS LLC | 2,896,074 | 1,667,360 | -1,228,714 | 1.85 | 1.19 | -0.66 | sell |