| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,140,861 | 4,043,865 | +1,903,004 | 0.01 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 1,433,691 | 2,547,683 | +1,113,992 | 0.04 | 0.07 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 0 | 777,288 | +777,288 | 0.00 | 0.10 | +0.10 | buy |
| T. Rowe Price Investment Management, Inc. | 1,640,692 | 2,417,493 | +776,801 | 0.03 | 0.06 | +0.02 | buy |
| STATE STREET CORP | 2,852,720 | 3,563,736 | +711,016 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 1,530,263 | 2,012,517 | +482,254 | 1.55 | 1.86 | +0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,578,199 | 3,008,858 | +430,659 | 0.01 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 1,583,329 | 1,987,772 | +404,443 | 4.47 | 5.69 | +1.22 | buy |
| Fisher Asset Management, LLC | 53,860 | 441,295 | +387,435 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 288,011 | +288,011 | 0.00 | 0.07 | +0.07 | buy |
| FRANKLIN RESOURCES INC | 138,825 | 413,209 | +274,384 | 0.00 | 0.01 | +0.00 | buy |
| Laurion Capital Management LP | 346,637 | 568,982 | +222,345 | 0.27 | 0.73 | +0.46 | buy |
| BANK OF AMERICA CORP /DE/ | 154,900 | 344,413 | +189,513 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,990 | 184,107 | +139,117 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 511,321 | 648,251 | +136,930 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,178,737 | 2,312,919 | +134,182 | 4.42 | 3.86 | -0.56 | buy |
| Pier Capital, LLC | 0 | 116,603 | +116,603 | 0.00 | 0.59 | +0.59 | buy |
| Aberdeen Group plc | 0 | 101,196 | +101,196 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 28,939 | 127,682 | +98,743 | 0.01 | 0.06 | +0.05 | buy |
| GOLDMAN SACHS GROUP INC | 552,598 | 650,173 | +97,575 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,407,035 | 3,502,452 | +95,417 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 282,599 | 373,629 | +91,030 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 12,812 | 103,034 | +90,222 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,269,674 | 1,352,672 | +82,998 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 113,282 | 190,984 | +77,702 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 73,457 | +73,457 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 59,800 | +59,800 | 0.00 | 0.23 | +0.23 | buy |
| MBB PUBLIC MARKETS I LLC | 8,702 | 66,433 | +57,731 | 0.02 | 0.15 | +0.13 | buy |
| Qube Research & Technologies Ltd | 0 | 57,715 | +57,715 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 81,858 | 138,465 | +56,607 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 384,685 | 435,685 | +51,000 | 0.02 | 0.03 | +0.01 | buy |
| Lisanti Capital Growth, LLC | 49,980 | 100,245 | +50,265 | 0.23 | 0.84 | +0.61 | buy |
| DEUTSCHE BANK AG\ | 30,210 | 80,427 | +50,217 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 1,101,904 | 1,150,000 | +48,096 | 1.91 | 1.96 | +0.05 | buy |
| Rafferty Asset Management, LLC | 197,741 | 244,289 | +46,548 | 0.03 | 0.04 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,018,782 | 1,059,633 | +40,851 | 0.54 | 0.62 | +0.07 | buy |
| JPMORGAN CHASE & CO | 54,430 | 93,104 | +38,674 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 139,426 | 176,426 | +37,000 | 0.01 | 0.01 | +0.00 | buy |
| AWM Investment Company, Inc. | 15,000 | 50,000 | +35,000 | 0.07 | 0.23 | +0.17 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,208 | 61,608 | +32,400 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 30,892 | 62,118 | +31,226 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 633,364 | 658,289 | +24,925 | 0.06 | 0.07 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 100,000 | 120,652 | +20,652 | 0.54 | 0.61 | +0.06 | buy |
| CITIGROUP INC | 83,772 | 102,311 | +18,539 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 17,680 | +17,680 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,883 | 80,966 | +17,083 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 15,899 | +15,899 | 0.00 | 0.21 | +0.21 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 15,667 | +15,667 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 7,411 | 22,644 | +15,233 | 0.01 | 0.02 | +0.01 | buy |
| Zimmer Partners, LP | 15,000 | 28,700 | +13,700 | 0.01 | 0.04 | +0.03 | buy |
| NEOS Investment Management LLC | 0 | 13,481 | +13,481 | 0.00 | 0.05 | +0.05 | buy |
| OSAIC HOLDINGS, INC. | 3,448 | 16,456 | +13,008 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,913 | +12,913 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 94,189 | 105,005 | +10,816 | 0.54 | 0.66 | +0.12 | buy |
| ROYAL BANK OF CANADA | 10,804 | 21,015 | +10,211 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 461,303 | 470,373 | +9,070 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 7,900 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 50,272 | 57,768 | +7,496 | 0.00 | 0.01 | +0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 7,446 | +7,446 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 69,502 | 76,575 | +7,073 | 0.01 | 0.02 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,000 | 39,764 | +6,764 | 0.01 | 0.02 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 6,738 | +6,738 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 6,686 | +6,686 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 6,631 | +6,631 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,403 | 7,721 | +6,318 | 0.01 | 0.05 | +0.04 | buy |
| PROFUND ADVISORS LLC | 33,826 | 40,134 | +6,308 | 0.06 | 0.06 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,140 | 67,270 | +6,130 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 40,328 | 46,025 | +5,697 | 0.01 | 0.01 | +0.00 | buy |
| RWA WEALTH PARTNERS, LLC | 0 | 5,696 | +5,696 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 35,217 | 40,603 | +5,386 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 597,324 | 602,422 | +5,098 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 132,629 | 136,945 | +4,316 | 0.01 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 0 | 4,250 | +4,250 | 0.00 | 0.11 | +0.11 | buy |
| ProShare Advisors LLC | 11,971 | 15,076 | +3,105 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,155 | 13,069 | +2,914 | 0.02 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 34,563 | 37,160 | +2,597 | 0.07 | 0.08 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 36,875 | 39,218 | +2,343 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,564 | 3,603 | +2,039 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,358 | 16,966 | +1,608 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 1,820 | 3,352 | +1,532 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,000 | +1,000 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 52,879 | 53,606 | +727 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 106,554 | 107,215 | +661 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 53,603 | 54,105 | +502 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 439 | +439 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 62,826 | 63,175 | +349 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,477 | 6,759 | +282 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 32,250 | 32,457 | +207 | 0.01 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 6,298 | 6,499 | +201 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 41 | 119 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 199 | 273 | +74 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,681 | 27,725 | +44 | 0.00 | 0.00 | +0.00 | buy |
| West Tower Group, LLC | 140 | 176 | +36 | 0.00 | 0.01 | +0.01 | buy |
| Farther Finance Advisors, LLC | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,742 | 4,742 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SANDERS MORRIS HARRIS LLC | 18,600 | 18,600 | 0 | 0.11 | 0.33 | +0.22 | hold |
| Novo Holdings A/S | 1,100,000 | 1,100,000 | 0 | 2.42 | 2.42 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 11,300 | 11,300 | 0 | 0.00 | 0.00 | +0.00 | hold |