| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Siren, L.L.C. | 1,309,652 | 1,609,652 | +300,000 | 3.35 | 3.64 | +0.29 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,885,248 | 6,141,014 | +255,766 | 2.58 | 2.59 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 213,815 | 317,060 | +103,245 | 3.28 | 4.07 | +0.79 | buy |
| First Turn Management, LLC | 353,376 | 453,376 | +100,000 | 2.86 | 4.15 | +1.29 | buy |
| MPM BioImpact LLC | 525,845 | 617,035 | +91,190 | 4.03 | 4.48 | +0.45 | buy |
| Ikarian Capital, LLC | 426,913 | 516,431 | +89,518 | 6.77 | 7.54 | +0.77 | buy |
| BNP Paribas Asset Management Holding S.A. | 491,381 | 576,068 | +84,687 | 0.06 | 0.07 | +0.01 | buy |
| Fisher Asset Management, LLC | 482,099 | 559,287 | +77,188 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 460,000 | +60,000 | 3.17 | 3.67 | +0.50 | buy |
| Nicholas Investment Partners, LP | 93,860 | 127,283 | +33,423 | 0.44 | 0.57 | +0.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 40,000 | 65,000 | +25,000 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 834,912 | 851,400 | +16,488 | 0.69 | 0.64 | -0.05 | buy |
| ALPS ADVISORS INC | 60,743 | 74,985 | +14,242 | 0.02 | 0.02 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 12,615 | 25,044 | +12,429 | 0.01 | 0.01 | +0.01 | buy |
| Decheng Capital LLC | 157,958 | 167,958 | +10,000 | 1.91 | 1.84 | -0.07 | buy |
| Aberdeen Group plc | 35,467 | 43,389 | +7,922 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 139,130 | 144,366 | +5,236 | 1.29 | 1.37 | +0.07 | buy |
| Rock Springs Capital Management LP | 289,400 | 294,100 | +4,700 | 0.48 | 0.57 | +0.09 | buy |
| CASTLEARK MANAGEMENT LLC | 73,340 | 77,780 | +4,440 | 0.15 | 0.14 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 15,393 | 19,664 | +4,271 | 0.09 | 0.09 | +0.01 | buy |
| Pier Capital, LLC | 108,361 | 111,999 | +3,638 | 0.78 | 0.82 | +0.04 | buy |
| SANDERS MORRIS HARRIS LLC | 18,600 | 21,100 | +2,500 | 0.16 | 0.16 | +0.00 | buy |
| NEOS Investment Management LLC | 57,389 | 57,933 | +544 | 0.09 | 0.07 | -0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 22,074 | 22,484 | +410 | 0.03 | 0.03 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 76 | 81 | +5 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 6,262 | 5,775 | -487 | 0.02 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 1,962 | 1,279 | -683 | 0.05 | 0.03 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 40,835 | 40,090 | -745 | 0.10 | 0.09 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 5,800 | 4,400 | -1,400 | 0.18 | 0.15 | -0.02 | sell |
| Lewis Asset Management, LLC | 12,175 | 9,780 | -2,395 | 0.45 | 0.38 | -0.07 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 131,700 | 122,900 | -8,800 | 5.45 | 6.32 | +0.87 | sell |
| Fiera Capital Corp | 466,075 | 454,982 | -11,093 | 0.07 | 0.07 | +0.00 | sell |
| Cinctive Capital Management LP | 49,445 | 36,988 | -12,457 | 0.14 | 0.10 | -0.04 | sell |
| LORD, ABBETT & CO. LLC | 746,118 | 724,625 | -21,493 | 0.12 | 0.12 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 108,575 | 82,700 | -25,875 | 1.41 | 1.02 | -0.39 | sell |
| Parkman Healthcare Partners LLC | 77,623 | 51,133 | -26,490 | 0.51 | 0.35 | -0.16 | sell |
| Calamos Advisors LLC | 41,558 | 14,402 | -27,156 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 88,425 | 53,125 | -35,300 | 0.76 | 0.56 | -0.20 | sell |
| Novo Holdings A/S | 1,000,000 | 960,215 | -39,785 | 2.54 | 2.97 | +0.43 | sell |
| Saturn V Capital Management LP | 109,567 | 59,125 | -50,442 | 2.00 | 1.18 | -0.82 | sell |
| ORBIMED ADVISORS LLC | 1,050,055 | 999,000 | -51,055 | 0.98 | 1.06 | +0.08 | sell |
| GW&K Investment Management, LLC | 732,892 | 679,123 | -53,769 | 0.32 | 0.30 | -0.03 | sell |
| First Light Asset Management, LLC | 943,611 | 885,453 | -58,158 | 4.01 | 4.33 | +0.32 | sell |
| T. Rowe Price Investment Management, Inc. | 1,068,532 | 1,002,882 | -65,650 | 0.03 | 0.03 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 2,793,614 | 2,708,351 | -85,263 | 0.09 | 0.08 | -0.00 | sell |
| Cormorant Asset Management, LP | 1,100,000 | 1,000,000 | -100,000 | 2.98 | 2.81 | -0.17 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 735,088 | 609,014 | -126,074 | 0.65 | 0.57 | -0.08 | sell |
| Duquesne Family Office LLC | 309,000 | 122,700 | -186,300 | 0.53 | 0.17 | -0.37 | sell |
| PERCEPTIVE ADVISORS LLC | 724,698 | 184,525 | -540,173 | 0.78 | 0.26 | -0.52 | sell |
| Paradigm Biocapital Advisors LP | 2,516,686 | 1,910,761 | -605,925 | 4.50 | 3.40 | -1.10 | sell |