| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,187,498 | 14,293,775 | +106,277 | 0.03 | 0.03 | +0.00 | buy |
| VANGUARD GROUP INC | 9,170,129 | 9,135,504 | -34,625 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 8,381,991 | 8,037,889 | -344,102 | 0.06 | 0.07 | +0.00 | sell |
| BlackRock, Inc. | 7,586,597 | 7,988,548 | +401,951 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 5,770,098 | 6,933,098 | +1,163,000 | 1.36 | 1.68 | +0.32 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 6,481,613 | 6,387,740 | -93,873 | 1.93 | 2.02 | +0.09 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,306,248 | 5,224,387 | -81,861 | 0.02 | 0.03 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 3,858,791 | 4,440,691 | +581,900 | 0.07 | 0.09 | +0.02 | buy |
| EcoR1 Capital, LLC | 4,288,120 | 4,288,120 | 0 | 8.57 | 9.11 | +0.54 | hold |
| Point72 Asset Management, L.P. | 2,003,333 | 2,337,034 | +333,701 | 0.18 | 0.17 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,278,830 | 2,242,631 | -36,199 | 0.01 | 0.01 | +0.00 | sell |
| Paradigm Biocapital Advisors LP | 2,550,774 | 2,210,774 | -340,000 | 3.14 | 2.76 | -0.39 | sell |
| STATE STREET CORP | 2,207,707 | 2,161,378 | -46,329 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 280,000 | 1,648,869 | +1,368,869 | 0.08 | 0.45 | +0.37 | buy |
| Novo Holdings A/S | 1,625,000 | 1,625,000 | 0 | 4.36 | 5.87 | +1.51 | hold |
| Pictet Asset Management Holding SA | 1,465,262 | 1,560,300 | +95,038 | 0.06 | 0.07 | +0.01 | buy |
| Siren, L.L.C. | 1,688,611 | 1,507,636 | -180,975 | 2.75 | 2.09 | -0.66 | sell |
| GW&K Investment Management, LLC | 850,546 | 1,476,325 | +625,779 | 0.31 | 0.59 | +0.28 | buy |
| RTW INVESTMENTS, LP | 872,387 | 1,351,326 | +478,939 | 0.45 | 0.63 | +0.18 | buy |
| BNP Paribas Asset Management Holding S.A. | 834,031 | 1,327,382 | +493,351 | 0.09 | 0.07 | -0.02 | buy |
| JENNISON ASSOCIATES LLC | 2,044,734 | 1,281,601 | -763,133 | 0.05 | 0.04 | -0.01 | sell |
| First Light Asset Management, LLC | 941,516 | 1,194,263 | +252,747 | 3.70 | 4.25 | +0.55 | buy |
| JPMORGAN CHASE & CO | 1,258,722 | 1,154,710 | -104,012 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 1,133,535 | 1,068,878 | -64,657 | 0.02 | 0.03 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 1,099,000 | 999,000 | -100,000 | 1.10 | 0.95 | -0.15 | sell |
| UBS Group AG | 407,722 | 908,192 | +500,470 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 883,004 | 897,403 | +14,399 | 0.43 | 0.46 | +0.02 | buy |
| Candriam S.C.A. | 745,094 | 830,961 | +85,867 | 0.16 | 0.19 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 601,042 | 801,314 | +200,272 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 778,652 | 781,981 | +3,329 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 809,888 | 769,823 | -40,065 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 682,134 | 768,826 | +86,692 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 758,357 | 758,659 | +302 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 339,949 | 674,533 | +334,584 | 0.02 | 0.05 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 614,816 | 601,190 | -13,626 | 0.01 | 0.01 | +0.00 | sell |
| Fiera Capital Corp | 435,425 | 578,455 | +143,030 | 0.06 | 0.09 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 713,130 | 567,127 | -146,003 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 377,802 | 548,977 | +171,175 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 544,754 | 522,466 | -22,288 | 0.01 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 387,925 | 408,312 | +20,387 | 0.03 | 0.03 | +0.00 | buy |
| Bank of New York Mellon Corp | 399,634 | 405,010 | +5,376 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 248,368 | 309,368 | +61,000 | 1.02 | 1.08 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 34,694 | 302,001 | +267,307 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 216,244 | 300,335 | +84,091 | 0.01 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 400,000 | 300,000 | -100,000 | 1.15 | 0.79 | -0.36 | sell |
| Ensign Peak Advisors, Inc | 295,008 | 275,616 | -19,392 | 0.02 | 0.02 | +0.00 | sell |
| Impax Asset Management Group plc | 0 | 275,000 | +275,000 | 0.00 | 0.08 | +0.08 | buy |
| Prosight Management, LP | 328,684 | 262,904 | -65,780 | 3.29 | 2.53 | -0.76 | sell |
| CITADEL ADVISORS LLC | 884,507 | 254,720 | -629,787 | 0.03 | 0.01 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 232,365 | 235,018 | +2,653 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 14,045 | 233,197 | +219,152 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 217,690 | 225,842 | +8,152 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 178,584 | 213,891 | +35,307 | 0.03 | 0.04 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 203,548 | 190,478 | -13,070 | 0.01 | 0.01 | +0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 180,849 | 189,477 | +8,628 | 0.10 | 0.12 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 87,318 | 187,433 | +100,115 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 183,236 | 185,677 | +2,441 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 67,148 | 182,188 | +115,040 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 172,500 | 176,500 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 174,077 | 171,830 | -2,247 | 0.40 | 0.44 | +0.04 | sell |
| Invesco Ltd. | 89,393 | 158,089 | +68,696 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 147,813 | 148,489 | +676 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 148,277 | 146,123 | -2,154 | 0.01 | 0.01 | +0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 144,239 | +144,239 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 98,702 | 139,461 | +40,759 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 233,386 | 138,685 | -94,701 | 0.01 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 52,665 | 130,363 | +77,698 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 174,841 | 124,841 | -50,000 | 1.84 | 0.96 | -0.88 | sell |
| Russell Investments Group, Ltd. | 148,982 | 119,905 | -29,077 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 131,522 | 115,752 | -15,770 | 0.00 | 0.00 | -0.00 | sell |
| SECTOR GAMMA AS | 0 | 115,000 | +115,000 | 0.00 | 1.22 | +1.22 | buy |
| MOODY ALDRICH PARTNERS LLC | 115,543 | 110,415 | -5,128 | 0.91 | 0.96 | +0.05 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 12,544 | 100,567 | +88,023 | 0.00 | 0.01 | +0.01 | buy |
| AWM Investment Company, Inc. | 100,000 | 100,000 | 0 | 0.39 | 0.45 | +0.06 | hold |
| ALLIANCEBERNSTEIN L.P. | 93,020 | 93,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Decheng Capital LLC | 143,000 | 92,700 | -50,300 | 1.04 | 0.58 | -0.46 | sell |
| Legal & General Group Plc | 93,809 | 87,802 | -6,007 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,179 | 85,568 | +1,389 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 47,415 | 77,765 | +30,350 | 0.01 | 0.02 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 75,000 | 75,000 | 0 | 0.29 | 0.25 | -0.04 | hold |
| SEI INVESTMENTS CO | 60,340 | 72,045 | +11,705 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 62,790 | +62,790 | 0.00 | 0.09 | +0.09 | buy |
| Man Group plc | 0 | 62,560 | +62,560 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 60,584 | 59,121 | -1,463 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,025 | 55,561 | -1,464 | 0.01 | 0.01 | +0.00 | sell |
| Phocas Financial Corp. | 54,015 | 53,877 | -138 | 0.29 | 0.33 | +0.03 | sell |
| MetLife Investment Management, LLC | 53,414 | 49,818 | -3,596 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 49,699 | 49,699 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 40,572 | 47,321 | +6,749 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 170,495 | 47,295 | -123,200 | 0.00 | 0.00 | -0.00 | sell |
| Vestmark Advisory Solutions, Inc. | 0 | 46,552 | +46,552 | 0.00 | 0.03 | +0.03 | buy |
| Lisanti Capital Growth, LLC | 22,890 | 43,040 | +20,150 | 0.23 | 0.47 | +0.24 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,009 | 42,002 | -7 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 257,505 | 33,511 | -223,994 | 0.02 | 0.00 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 0 | 33,354 | +33,354 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 6,931 | 33,150 | +26,219 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 72,349 | 30,537 | -41,812 | 0.01 | 0.01 | -0.01 | sell |
| Orion Porfolio Solutions, LLC | 16,862 | 30,495 | +13,633 | 0.01 | 0.01 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,225 | 30,243 | +8,018 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 32,100 | 29,500 | -2,600 | 0.00 | 0.00 | -0.00 | sell |