| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,630,541 | 16,727,909 | +97,368 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 8,828,836 | 8,827,085 | -1,751 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 8,284,882 | 8,334,882 | +50,000 | 2.27 | 2.32 | +0.05 | buy |
| TCG Crossover Management, LLC | 6,243,812 | 6,243,812 | 0 | 2.48 | 2.70 | +0.21 | hold |
| Commodore Capital LP | 5,650,000 | 5,650,000 | 0 | 4.54 | 6.04 | +1.50 | hold |
| Saturn V Capital Management LP | 4,349,885 | 4,624,101 | +274,216 | 10.95 | 11.91 | +0.96 | buy |
| MORGAN STANLEY | 2,175,547 | 3,130,808 | +955,261 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,987,147 | 3,036,970 | +49,823 | 0.31 | 0.32 | +0.01 | buy |
| First Light Asset Management, LLC | 3,190,645 | 3,023,256 | -167,389 | 3.97 | 3.30 | -0.67 | sell |
| FRANKLIN RESOURCES INC | 2,261,569 | 2,950,225 | +688,656 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,625,991 | 2,858,239 | +232,248 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,363,161 | 2,603,337 | +240,176 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,210,932 | 2,335,315 | +124,383 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,560,764 | 1,900,000 | -1,660,764 | 0.08 | 0.05 | -0.03 | sell |
| JPMORGAN CHASE & CO | 159,663 | 1,863,650 | +1,703,987 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 1,230,000 | 1,480,586 | +250,586 | 0.47 | 0.54 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,958 | 1,327,536 | -186,422 | 0.35 | 0.32 | -0.03 | sell |
| 683 Capital Management, LLC | 1,530,000 | 1,279,512 | -250,488 | 1.97 | 2.11 | +0.14 | sell |
| Alyeska Investment Group, L.P. | 0 | 1,053,015 | +1,053,015 | 0.00 | 0.05 | +0.05 | buy |
| Almitas Capital LLC | 2,122,597 | 974,881 | -1,147,716 | 6.67 | 4.20 | -2.47 | sell |
| DIMENSIONAL FUND ADVISORS LP | 903,192 | 902,463 | -729 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 845,800 | 846,387 | +587 | 0.04 | 0.05 | +0.00 | buy |
| NORTHERN TRUST CORP | 779,908 | 831,740 | +51,832 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,330,689 | 821,841 | -508,848 | 0.00 | 0.00 | -0.00 | sell |
| Boxer Capital Management, LLC | 800,000 | 800,000 | 0 | 1.46 | 1.08 | -0.38 | hold |
| Aberdeen Group plc | 0 | 737,670 | +737,670 | 0.00 | 0.02 | +0.02 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 725,030 | +725,030 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 716,225 | 725,030 | +8,805 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 868,325 | 721,002 | -147,323 | 0.03 | 0.02 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 1,750,000 | 700,000 | -1,050,000 | 5.96 | 2.96 | -3.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,107,271 | 684,974 | -422,297 | 0.03 | 0.02 | -0.01 | sell |
| Qube Research & Technologies Ltd | 702,236 | 681,389 | -20,847 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 161,945 | 593,435 | +431,490 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 1,267,785 | 557,937 | -709,848 | 0.01 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 499,764 | 499,764 | 0 | 0.41 | 0.44 | +0.03 | hold |
| ADAR1 Capital Management, LLC | 1,000,604 | 494,378 | -506,226 | 0.84 | 0.42 | -0.42 | sell |
| Nantahala Capital Management, LLC | 535,684 | 486,684 | -49,000 | 0.46 | 0.53 | +0.06 | sell |
| FEDERATED HERMES, INC. | 363,546 | 462,205 | +98,659 | 0.01 | 0.01 | +0.00 | buy |
| Nearwater Capital Markets, Ltd | 0 | 425,000 | +425,000 | 0.00 | 0.13 | +0.13 | buy |
| Parkman Healthcare Partners LLC | 621,458 | 398,782 | -222,676 | 0.90 | 0.74 | -0.16 | sell |
| HighVista Strategies LLC | 352,085 | 386,080 | +33,995 | 1.35 | 1.58 | +0.23 | buy |
| STEMPOINT CAPITAL LP | 669,685 | 384,304 | -285,381 | 1.79 | 1.19 | -0.59 | sell |
| Logos Global Management LP | 700,000 | 350,000 | -350,000 | 0.50 | 0.27 | -0.23 | sell |
| Trexquant Investment LP | 0 | 349,439 | +349,439 | 0.00 | 0.04 | +0.04 | buy |
| Nuveen, LLC | 264,897 | 330,521 | +65,624 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 305,441 | +305,441 | 0.00 | 0.01 | +0.01 | buy |
| iA Global Asset Management Inc. | 304,786 | 303,786 | -1,000 | 0.06 | 0.06 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 299,565 | +299,565 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 317,877 | 297,926 | -19,951 | 0.87 | 0.87 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 592,654 | 274,944 | -317,710 | 0.04 | 0.02 | -0.02 | sell |
| Bank of New York Mellon Corp | 251,104 | 274,435 | +23,331 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 324,319 | 271,881 | -52,438 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 254,587 | +254,587 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 227,010 | 227,690 | +680 | 0.10 | 0.11 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 241,552 | 212,842 | -28,710 | 0.00 | 0.00 | +0.00 | sell |
| Cormorant Asset Management, LP | 350,000 | 200,000 | -150,000 | 0.25 | 0.18 | -0.06 | sell |
| Aldebaran Capital, LLC | 197,892 | 195,892 | -2,000 | 2.10 | 2.64 | +0.54 | sell |
| Walleye Capital LLC | 61,711 | 186,588 | +124,877 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 183,400 | +183,400 | 0.00 | 0.06 | +0.06 | buy |
| CITADEL ADVISORS LLC | 411,532 | 178,686 | -232,846 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 74,230 | 174,285 | +100,055 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157,089 | 173,407 | +16,318 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 151,067 | 168,115 | +17,048 | 1.49 | 2.10 | +0.61 | buy |
| NORGES BANK | 0 | 159,900 | +159,900 | 0.00 | 0.00 | +0.00 | buy |
| Alpha Wave Global, LP | 142,336 | 155,422 | +13,086 | 0.25 | 0.04 | -0.21 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 121,439 | 145,133 | +23,694 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 130,300 | 144,200 | +13,900 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 145,275 | 143,700 | -1,575 | 0.21 | 0.22 | +0.01 | sell |
| Invesco Ltd. | 171,620 | 139,942 | -31,678 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 75,083 | 128,164 | +53,081 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 125,484 | +125,484 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 122,909 | +122,909 | 0.00 | 0.07 | +0.07 | buy |
| Ikarian Capital, LLC | 0 | 117,500 | +117,500 | 0.00 | 0.35 | +0.35 | buy |
| RHUMBLINE ADVISERS | 108,467 | 112,920 | +4,453 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 89,983 | 112,447 | +22,464 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 80,800 | 104,400 | +23,600 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 54,422 | 100,963 | +46,541 | 0.04 | 0.10 | +0.05 | buy |
| Affinity Asset Advisors, LLC | 0 | 98,999 | +98,999 | 0.00 | 0.09 | +0.09 | buy |
| Quantinno Capital Management LP | 0 | 80,850 | +80,850 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,002 | 79,872 | +14,870 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 0 | 79,751 | +79,751 | 0.00 | 0.42 | +0.42 | buy |
| Russell Investments Group, Ltd. | 59,346 | 78,971 | +19,625 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31,782 | 68,684 | +36,902 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 77,794 | 66,804 | -10,990 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 72,061 | 61,278 | -10,783 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 0 | 59,322 | +59,322 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 57,802 | +57,802 | 0.00 | 0.19 | +0.19 | buy |
| Legal & General Group Plc | 55,773 | 56,477 | +704 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 971,854 | 56,258 | -915,596 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 51,587 | 55,700 | +4,113 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 55,321 | +55,321 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 44,817 | +44,817 | 0.00 | 0.13 | +0.13 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,553 | 42,351 | -202 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 0 | 39,425 | +39,425 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 39,241 | +39,241 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,781 | 37,828 | -953 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 36,060 | +36,060 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 35,841 | +35,841 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 31,334 | 35,410 | +4,076 | 0.00 | 0.00 | +0.00 | buy |