| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 5,697,605 | +5,697,605 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 594,236 | 3,081,853 | +2,487,617 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 0 | 1,811,996 | +1,811,996 | 0.00 | 3.49 | +3.49 | buy |
| Woodline Partners LP | 0 | 1,609,447 | +1,609,447 | 0.00 | 0.04 | +0.04 | buy |
| Saturn V Capital Management LP | 889,073 | 2,426,436 | +1,537,363 | 1.32 | 4.33 | +3.02 | buy |
| Nantahala Capital Management, LLC | 1,452,153 | 2,934,405 | +1,482,252 | 0.38 | 0.86 | +0.48 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,471,587 | +1,471,587 | 0.00 | 1.00 | +1.00 | buy |
| VANGUARD GROUP INC | 2,692,489 | 4,116,512 | +1,424,023 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 4,643,812 | 5,943,812 | +1,300,000 | 1.72 | 2.87 | +1.15 | buy |
| PERCEPTIVE ADVISORS LLC | 6,774,348 | 7,874,348 | +1,100,000 | 0.71 | 0.99 | +0.28 | buy |
| Point72 Asset Management, L.P. | 0 | 916,966 | +916,966 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 0 | 834,135 | +834,135 | 0.00 | 0.23 | +0.23 | buy |
| CITADEL ADVISORS LLC | 1,970,704 | 2,757,776 | +787,072 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 643,524 | 1,388,427 | +744,903 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,722,805 | 2,430,358 | +707,553 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 868,382 | 1,470,925 | +602,543 | 0.00 | 0.01 | +0.00 | buy |
| 683 Capital Management, LLC | 1,930,000 | 2,411,400 | +481,400 | 0.72 | 0.87 | +0.15 | buy |
| FMR LLC | 731,356 | 1,157,988 | +426,632 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 241,400 | 649,800 | +408,400 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 343,228 | +343,228 | 0.00 | 0.07 | +0.07 | buy |
| Allostery Investments LP | 0 | 266,099 | +266,099 | 0.00 | 1.36 | +1.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 567,903 | 806,161 | +238,258 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 780,566 | 942,891 | +162,325 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,859,896 | 2,002,961 | +143,065 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 127,998 | +127,998 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 651,517 | 762,053 | +110,536 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 2,278,934 | 2,387,409 | +108,475 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 66,000 | 169,600 | +103,600 | 0.00 | 0.01 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 50,248 | 148,559 | +98,311 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 2,032,370 | 2,122,597 | +90,227 | 1.69 | 2.49 | +0.81 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 209,708 | 290,682 | +80,974 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 73,942 | +73,942 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 298,949 | 372,853 | +73,904 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 54,114 | 123,576 | +69,462 | 0.00 | 0.00 | +0.00 | buy |
| Kennondale Capital Management LLC | 134,445 | 202,743 | +68,298 | 0.55 | 0.78 | +0.23 | buy |
| MARSHALL WACE, LLP | 184,678 | 247,275 | +62,597 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 74,845 | 137,405 | +62,560 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 57,133 | +57,133 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 464,400 | 515,100 | +50,700 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 59,310 | 107,014 | +47,704 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 45,694 | +45,694 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 218,383 | 261,783 | +43,400 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 43,228 | +43,228 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 40,134 | +40,134 | 0.00 | 0.04 | +0.04 | buy |
| Alpha Wave Global, LP | 148,627 | 187,311 | +38,684 | 0.26 | 0.30 | +0.04 | buy |
| NORTHERN TRUST CORP | 106,564 | 139,332 | +32,768 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 25,500 | +25,500 | 0.00 | 0.25 | +0.25 | buy |
| Verition Fund Management LLC | 0 | 24,013 | +24,013 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 22,242 | +22,242 | 0.00 | 0.01 | +0.01 | buy |
| Premier Path Wealth Partners, LLC | 0 | 20,265 | +20,265 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 16,150 | +16,150 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 14,905 | +14,905 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,301 | +13,301 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 12,744 | +12,744 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 10,639 | 23,085 | +12,446 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 55,430 | 67,597 | +12,167 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 11,330 | +11,330 | 0.00 | 0.00 | +0.00 | buy |
| Capula Management Ltd | 0 | 10,980 | +10,980 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 10,340 | +10,340 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 464,220 | 474,418 | +10,198 | 0.00 | 0.00 | -0.00 | buy |
| Valeo Financial Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 15,958 | 25,210 | +9,252 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 146,500 | 155,700 | +9,200 | 0.01 | 0.01 | +0.00 | buy |
| R Squared Ltd | 6,370 | 12,736 | +6,366 | 0.02 | 0.05 | +0.02 | buy |
| Vanguard Personalized Indexing Management, LLC | 17,724 | 21,756 | +4,032 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 3,152 | +3,152 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 11,566 | 14,419 | +2,853 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,535 | 17,188 | +2,653 | 0.01 | 0.01 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2,229 | +2,229 | 0.00 | 0.01 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 35,868 | 37,796 | +1,928 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,069 | 6,700 | +1,631 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,284 | 2,930 | +646 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 75,284 | 75,849 | +565 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 202,316 | 202,785 | +469 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 50,539 | 50,906 | +367 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 274 | +274 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,439 | 1,700 | +261 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 4,796 | 5,047 | +251 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 238 | +238 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,149 | 1,363 | +214 | 0.00 | 0.00 | +0.00 | buy |
| PARSONS CAPITAL MANAGEMENT INC/RI | 21,645 | 21,645 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 348,000 | 348,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| BROWN ADVISORY INC | 19,930 | 19,930 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 266 | 266 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 890 | 890 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dunhill Financial, LLC | 600 | 600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marex Group plc | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Boxer Capital Management, LLC | 1,750,000 | 1,750,000 | 0 | 0.56 | 1.86 | +1.30 | hold |
| US BANCORP \DE\ | 4,000 | 4,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,700 | 57,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 90 | 90 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SALEM INVESTMENT COUNSELORS INC | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF MONTREAL /CAN/ | 143,512 | 143,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 1,803 | 1,803 | 0 | 0.00 | 0.00 | +0.00 | hold |