| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Siren, L.L.C. | 0 | 1,230,000 | +1,230,000 | 0.00 | 0.47 | +0.47 | buy |
| FRANKLIN RESOURCES INC | 1,200,096 | 2,261,569 | +1,061,473 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,777,055 | 3,560,764 | +783,709 | 0.05 | 0.08 | +0.03 | buy |
| BARCLAYS PLC | 295,177 | 971,854 | +676,677 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 15,574 | 592,654 | +577,080 | 0.00 | 0.04 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 4,465,872 | 4,986,073 | +520,201 | 0.02 | 0.03 | +0.01 | buy |
| iA Global Asset Management Inc. | 0 | 304,786 | +304,786 | 0.00 | 0.06 | +0.06 | buy |
| STATE STREET CORP | 2,069,884 | 2,363,161 | +293,277 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 412,873 | 702,236 | +289,363 | 0.01 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 858,684 | 1,107,271 | +248,587 | 0.02 | 0.03 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 381,760 | 621,458 | +239,698 | 0.44 | 0.90 | +0.46 | buy |
| DIMENSIONAL FUND ADVISORS LP | 771,248 | 903,192 | +131,944 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 238,812 | 352,085 | +113,273 | 0.74 | 1.35 | +0.61 | buy |
| FMR LLC | 16,518,419 | 16,630,541 | +112,122 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 890,356 | 1,000,604 | +110,248 | 0.80 | 0.84 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 565,140 | 669,685 | +104,545 | 1.17 | 1.79 | +0.62 | buy |
| JPMORGAN CHASE & CO | 66,547 | 159,663 | +93,116 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 344,968 | 411,532 | +66,564 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,838 | 157,089 | +58,251 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 21,052 | 77,794 | +56,742 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 5,740 | 61,711 | +55,971 | 0.00 | 0.01 | +0.00 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,165,534 | 2,210,932 | +45,398 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 272,828 | 317,877 | +45,049 | 0.69 | 0.87 | +0.17 | buy |
| Squarepoint Ops LLC | 76,562 | 114,877 | +38,315 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 217,347 | 251,104 | +33,757 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 52,856 | 85,279 | +32,423 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 32,001 | +32,001 | 0.00 | 0.22 | +0.22 | buy |
| State of New Jersey Common Pension Fund D | 0 | 22,519 | +22,519 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 17,883 | +17,883 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 225,782 | 241,552 | +15,770 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 14,120 | +14,120 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 107,548 | 121,439 | +13,891 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 12,895 | +12,895 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,613,221 | 2,625,991 | +12,770 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,988 | 38,781 | +11,793 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 11,414 | +11,414 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 10,768 | +10,768 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 134,549 | 145,275 | +10,726 | 0.16 | 0.21 | +0.05 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 10,380 | +10,380 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 71,500 | 80,800 | +9,300 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 99,274 | 108,467 | +9,193 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 9,014 | +9,014 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 22,402 | 31,334 | +8,932 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 218,399 | 227,010 | +8,611 | 0.08 | 0.10 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,877 | 40,790 | +4,913 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,990 | 716,225 | +3,235 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 20,840 | 24,072 | +3,232 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 49,654 | 51,587 | +1,933 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,863 | +1,863 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,895 | 19,488 | +1,593 | 0.02 | 0.02 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,166 | 42,553 | +1,387 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,847 | 29,089 | +1,242 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 261 | 1,274 | +1,013 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 73,224 | 74,230 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,148 | 1,513,958 | +810 | 0.29 | 0.35 | +0.06 | buy |
| FIFTH THIRD BANCORP | 0 | 755 | +755 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 20,307 | 20,815 | +508 | 0.07 | 0.08 | +0.01 | buy |
| State of Wyoming | 1,381 | 1,883 | +502 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 845,408 | 845,800 | +392 | 0.04 | 0.04 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,337 | 5,728 | +391 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,158 | 2,455 | +297 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 25,243 | 25,513 | +270 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 254 | +254 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 123 | 377 | +254 | 0.00 | 0.00 | +0.00 | buy |
| EASTERN BANK | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 41 | 201 | +160 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 267 | 417 | +150 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 153 | 282 | +129 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,315 | 1,418 | +103 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,552 | 10,644 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,193 | 1,263 | +70 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,000 | 2,063 | +63 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 12 | 40 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 9 | +9 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 25 | 26 | +1 | 0.00 | 0.00 | -0.00 | buy |
| PARSONS CAPITAL MANAGEMENT INC/RI | 21,645 | 21,645 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,203 | 7,203 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 8,284,882 | 8,284,882 | 0 | 1.83 | 2.27 | +0.44 | hold |
| GREAT POINT PARTNERS LLC | 1,750,000 | 1,750,000 | 0 | 6.85 | 5.96 | -0.90 | hold |
| BROWN ADVISORY INC | 19,930 | 19,930 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Informed Momentum Co LLC | 53,256 | 53,256 | 0 | 0.07 | 0.09 | +0.01 | hold |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 12,226 | 12,226 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rock Springs Capital Management LP | 499,764 | 499,764 | 0 | 0.31 | 0.41 | +0.10 | hold |
| Almitas Capital LLC | 2,122,597 | 2,122,597 | 0 | 5.65 | 6.67 | +1.02 | hold |
| KLP KAPITALFORVALTNING AS | 17,400 | 17,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 274 | 274 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 5,650,000 | 5,650,000 | 0 | 4.54 | 4.54 | +0.00 | hold |
| TCG Crossover Management, LLC | 6,243,812 | 6,243,812 | 0 | 2.50 | 2.48 | -0.01 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dunhill Financial, LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Premier Path Wealth Partners, LLC | 20,265 | 20,265 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Boxer Capital Management, LLC | 800,000 | 800,000 | 0 | 2.12 | 1.46 | -0.66 | hold |
| Westfuller Advisors, LLC | 819 | 819 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 23,752 | 23,752 | 0 | 0.00 | 0.00 | +0.00 | hold |