| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,518,419 | 16,630,541 | +112,122 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 9,054,431 | 8,828,836 | -225,595 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 8,284,882 | 8,284,882 | 0 | 1.83 | 2.27 | +0.44 | hold |
| TCG Crossover Management, LLC | 6,243,812 | 6,243,812 | 0 | 2.50 | 2.48 | -0.01 | hold |
| Commodore Capital LP | 5,650,000 | 5,650,000 | 0 | 4.54 | 4.54 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 4,465,872 | 4,986,073 | +520,201 | 0.02 | 0.03 | +0.01 | buy |
| Saturn V Capital Management LP | 4,496,487 | 4,349,885 | -146,602 | 9.97 | 10.95 | +0.98 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,777,055 | 3,560,764 | +783,709 | 0.05 | 0.08 | +0.03 | buy |
| First Light Asset Management, LLC | 3,355,539 | 3,190,645 | -164,894 | 3.10 | 3.97 | +0.88 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,109,503 | 2,987,147 | -122,356 | 0.26 | 0.31 | +0.05 | sell |
| GOLDMAN SACHS GROUP INC | 2,613,221 | 2,625,991 | +12,770 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,069,884 | 2,363,161 | +293,277 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,200,096 | 2,261,569 | +1,061,473 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,165,534 | 2,210,932 | +45,398 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 2,359,824 | 2,175,547 | -184,277 | 0.00 | 0.00 | +0.00 | sell |
| Almitas Capital LLC | 2,122,597 | 2,122,597 | 0 | 5.65 | 6.67 | +1.02 | hold |
| GREAT POINT PARTNERS LLC | 1,750,000 | 1,750,000 | 0 | 6.85 | 5.96 | -0.90 | hold |
| 683 Capital Management, LLC | 1,650,000 | 1,530,000 | -120,000 | 1.66 | 1.97 | +0.32 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,513,148 | 1,513,958 | +810 | 0.29 | 0.35 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 1,336,010 | 1,330,689 | -5,321 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 1,333,236 | 1,267,785 | -65,451 | 0.01 | 0.01 | +0.00 | sell |
| Siren, L.L.C. | 0 | 1,230,000 | +1,230,000 | 0.00 | 0.47 | +0.47 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 858,684 | 1,107,271 | +248,587 | 0.02 | 0.03 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 890,356 | 1,000,604 | +110,248 | 0.80 | 0.84 | +0.03 | buy |
| BARCLAYS PLC | 295,177 | 971,854 | +676,677 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 771,248 | 903,192 | +131,944 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,004,021 | 868,325 | -135,696 | 0.03 | 0.03 | -0.00 | sell |
| Woodline Partners LP | 845,408 | 845,800 | +392 | 0.04 | 0.04 | +0.00 | buy |
| Boxer Capital Management, LLC | 800,000 | 800,000 | 0 | 2.12 | 1.46 | -0.66 | hold |
| NORTHERN TRUST CORP | 937,764 | 779,908 | -157,856 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 712,990 | 716,225 | +3,235 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 412,873 | 702,236 | +289,363 | 0.01 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 950,000 | 700,000 | -250,000 | 0.76 | 0.50 | -0.26 | sell |
| STEMPOINT CAPITAL LP | 565,140 | 669,685 | +104,545 | 1.17 | 1.79 | +0.62 | buy |
| Parkman Healthcare Partners LLC | 381,760 | 621,458 | +239,698 | 0.44 | 0.90 | +0.46 | buy |
| JUPITER ASSET MANAGEMENT LTD | 15,574 | 592,654 | +577,080 | 0.00 | 0.04 | +0.04 | buy |
| Nantahala Capital Management, LLC | 835,684 | 535,684 | -300,000 | 0.60 | 0.46 | -0.14 | sell |
| Rock Springs Capital Management LP | 499,764 | 499,764 | 0 | 0.31 | 0.41 | +0.10 | hold |
| CITADEL ADVISORS LLC | 344,968 | 411,532 | +66,564 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 457,412 | 363,546 | -93,866 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 238,812 | 352,085 | +113,273 | 0.74 | 1.35 | +0.61 | buy |
| Cormorant Asset Management, LP | 400,000 | 350,000 | -50,000 | 0.27 | 0.25 | -0.03 | sell |
| UBS Group AG | 543,323 | 324,319 | -219,004 | 0.00 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 272,828 | 317,877 | +45,049 | 0.69 | 0.87 | +0.17 | buy |
| iA Global Asset Management Inc. | 0 | 304,786 | +304,786 | 0.00 | 0.06 | +0.06 | buy |
| Nuveen, LLC | 283,948 | 264,897 | -19,051 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 217,347 | 251,104 | +33,757 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 225,782 | 241,552 | +15,770 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 218,399 | 227,010 | +8,611 | 0.08 | 0.10 | +0.02 | buy |
| Aldebaran Capital, LLC | 198,508 | 197,892 | -616 | 2.15 | 2.10 | -0.05 | sell |
| Invesco Ltd. | 175,914 | 171,620 | -4,294 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 344,401 | 161,945 | -182,456 | 0.01 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 66,547 | 159,663 | +93,116 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,838 | 157,089 | +58,251 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 333,258 | 151,067 | -182,191 | 2.73 | 1.49 | -1.24 | sell |
| PFM Health Sciences, LP | 134,549 | 145,275 | +10,726 | 0.16 | 0.21 | +0.05 | buy |
| Alpha Wave Global, LP | 317,678 | 142,336 | -175,342 | 0.47 | 0.25 | -0.22 | sell |
| Swiss National Bank | 161,700 | 130,300 | -31,400 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 107,548 | 121,439 | +13,891 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 76,562 | 114,877 | +38,315 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 99,274 | 108,467 | +9,193 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 335,000 | 106,535 | -228,465 | 0.01 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 90,172 | 89,983 | -189 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 52,856 | 85,279 | +32,423 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 71,500 | 80,800 | +9,300 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 21,052 | 77,794 | +56,742 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 146,309 | 75,083 | -71,226 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 73,224 | 74,230 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 84,144 | 72,061 | -12,083 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,090 | 65,002 | -14,088 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 5,740 | 61,711 | +55,971 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 65,438 | 59,346 | -6,092 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 72,612 | 55,773 | -16,839 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 78,763 | 54,422 | -24,341 | 0.05 | 0.04 | -0.00 | sell |
| Informed Momentum Co LLC | 53,256 | 53,256 | 0 | 0.07 | 0.09 | +0.01 | hold |
| MetLife Investment Management, LLC | 49,654 | 51,587 | +1,933 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Numerai GP LLC | 112,648 | 48,553 | -64,095 | 0.16 | 0.07 | -0.10 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,166 | 42,553 | +1,387 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35,877 | 40,790 | +4,913 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,892 | 39,802 | -29,090 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,988 | 38,781 | +11,793 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 32,001 | +32,001 | 0.00 | 0.22 | +0.22 | buy |
| CITIGROUP INC | 38,032 | 31,782 | -6,250 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 22,402 | 31,334 | +8,932 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,847 | 29,089 | +1,242 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 27,234 | 27,234 | 0 | 0.07 | 0.07 | -0.00 | hold |
| GUGGENHEIM CAPITAL LLC | 25,243 | 25,513 | +270 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 32,006 | 24,921 | -7,085 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 20,840 | 24,072 | +3,232 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 23,752 | 23,752 | 0 | 0.00 | 0.00 | +0.00 | hold |
| State of New Jersey Common Pension Fund D | 0 | 22,519 | +22,519 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,900 | 21,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PARSONS CAPITAL MANAGEMENT INC/RI | 21,645 | 21,645 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 25,201 | 21,140 | -4,061 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 20,307 | 20,815 | +508 | 0.07 | 0.08 | +0.01 | buy |
| Premier Path Wealth Partners, LLC | 20,265 | 20,265 | 0 | 0.03 | 0.04 | +0.01 | hold |
| BROWN ADVISORY INC | 19,930 | 19,930 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Headlands Technologies LLC | 30,543 | 19,814 | -10,729 | 0.03 | 0.03 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,895 | 19,488 | +1,593 | 0.02 | 0.02 | +0.00 | buy |