| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 6,034,644 | 4,873,919 | +1,160,725 | 4.62 | 3.06 | 0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,984,333 | 1,050,198 | +934,135 | 1.30 | 0.48 | 0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,074,610 | 1,921,631 | +847,021 | 0.05 | 0.06 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 420,841 | 1,173,853 | +753,012 | 0.04 | 0.07 | 0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,022,370 | 1,590,044 | +432,326 | 0.11 | 0.06 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,007,336 | 768,200 | +239,136 | 0.07 | 0.04 | 0.00 | sell |
| GREAT POINT PARTNERS LLC | 783,795 | 968,795 | +185,000 | 4.55 | 4.19 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 242,400 | 387,310 | +144,910 | 1.37 | 1.39 | 0.00 | buy |
| EMERALD ADVISERS, LLC | 972,835 | 831,808 | +141,027 | 1.37 | 0.79 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 393,904 | 513,091 | +119,187 | 0.14 | 0.14 | 0.00 | buy |
| Rock Springs Capital Management LP | 1,452,816 | 1,544,616 | +91,800 | 1.02 | 0.79 | -0.22 | buy |
| TWINBEECH CAPITAL LP | 131,772 | 156,048 | +24,276 | 0.08 | 0.07 | 0.00 | buy |
| ALPS ADVISORS INC | 43,656 | 49,380 | +5,724 | 0.01 | 0.01 | 0.00 | buy |
| PROFUND ADVISORS LLC | 12,939 | 13,810 | +871 | 0.02 | 0.02 | 0.00 | buy |