| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,697,605 | 8,800,000 | +3,102,395 | 0.04 | 0.10 | +0.06 | buy |
| PERCEPTIVE ADVISORS LLC | 7,874,348 | 7,902,365 | +28,017 | 0.99 | 1.90 | +0.91 | buy |
| TCG Crossover Management, LLC | 5,943,812 | 5,943,812 | 0 | 2.87 | 4.35 | +1.48 | hold |
| BlackRock, Inc. | 2,387,409 | 5,510,189 | +3,122,780 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 916,966 | 4,536,266 | +3,619,300 | 0.01 | 0.07 | +0.06 | buy |
| VANGUARD GROUP INC | 4,116,512 | 4,498,028 | +381,516 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 2,426,436 | 3,260,570 | +834,134 | 4.33 | 8.47 | +4.14 | buy |
| FMR LLC | 1,157,988 | 3,048,019 | +1,890,031 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 2,934,405 | 2,934,405 | 0 | 0.86 | 1.33 | +0.47 | hold |
| 683 Capital Management, LLC | 2,411,400 | 2,160,000 | -251,400 | 0.87 | 1.40 | +0.54 | sell |
| Almitas Capital LLC | 2,122,597 | 2,122,597 | 0 | 2.49 | 3.43 | +0.94 | hold |
| GREAT POINT PARTNERS LLC | 1,811,996 | 2,000,000 | +188,004 | 3.49 | 8.34 | +4.85 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 806,161 | 1,692,413 | +886,252 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,081,853 | 1,512,058 | -1,569,795 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,002,961 | 1,297,982 | -704,979 | 0.00 | 0.00 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,264,997 | +1,264,997 | 0.00 | 0.06 | +0.06 | buy |
| UBS Group AG | 1,388,427 | 1,253,344 | -135,083 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 2,757,776 | 1,242,927 | -1,514,849 | 0.01 | 0.01 | -0.00 | sell |
| Boxer Capital Management, LLC | 1,750,000 | 1,225,000 | -525,000 | 1.86 | 3.95 | +2.09 | sell |
| ADAR1 Capital Management, LLC | 1,471,587 | 1,205,101 | -266,486 | 1.00 | 1.25 | +0.25 | sell |
| Woodline Partners LP | 1,609,447 | 1,200,290 | -409,157 | 0.04 | 0.04 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 1,199,691 | 1,154,485 | -45,206 | 0.02 | 0.03 | +0.01 | sell |
| STATE STREET CORP | 261,783 | 1,008,909 | +747,126 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 139,332 | 820,164 | +680,832 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 2,430,358 | 738,657 | -1,691,701 | 0.02 | 0.01 | -0.01 | sell |
| PFM Health Sciences, LP | 834,135 | 732,256 | -101,879 | 0.23 | 0.41 | +0.18 | sell |
| Parkman Healthcare Partners LLC | 0 | 650,000 | +650,000 | 0.00 | 0.48 | +0.48 | buy |
| Schonfeld Strategic Advisors LLC | 117,140 | 646,443 | +529,303 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 570,857 | 616,919 | +46,062 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 372,853 | 588,411 | +215,558 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 45,694 | 586,883 | +541,189 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 242,107 | 569,083 | +326,976 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 762,053 | 558,846 | -203,207 | 0.01 | 0.01 | +0.00 | sell |
| Rock Springs Capital Management LP | 343,228 | 499,764 | +156,536 | 0.07 | 0.20 | +0.13 | buy |
| MORGAN STANLEY | 474,418 | 486,893 | +12,475 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 649,800 | 470,000 | -179,800 | 0.01 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 794,354 | 451,808 | -342,546 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 942,891 | 438,026 | -504,865 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 515,100 | 396,200 | -118,900 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 123,576 | 373,739 | +250,163 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 348,000 | 313,200 | -34,800 | 0.03 | 0.05 | +0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 290,682 | 288,618 | -2,064 | 0.00 | 0.00 | +0.00 | sell |
| Alpha Wave Global, LP | 187,311 | 275,842 | +88,531 | 0.30 | 0.19 | -0.10 | buy |
| J. Goldman & Co LP | 0 | 258,600 | +258,600 | 0.00 | 0.05 | +0.05 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 240,379 | +240,379 | 0.00 | 0.04 | +0.04 | buy |
| TFG Asset Management GP Ltd | 0 | 218,750 | +218,750 | 0.00 | 0.25 | +0.25 | buy |
| Aldebaran Capital, LLC | 259,253 | 217,827 | -41,426 | 0.87 | 1.38 | +0.51 | sell |
| FEDERATED HERMES, INC. | 202,785 | 203,930 | +1,145 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 331,185 | 186,986 | -144,199 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 23,085 | 170,533 | +147,448 | 0.01 | 0.08 | +0.07 | buy |
| Nuveen, LLC | 0 | 155,536 | +155,536 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 270,006 | 151,502 | -118,504 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 0 | 150,837 | +150,837 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 143,512 | 143,512 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 107,014 | 134,380 | +27,366 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 137,405 | 130,274 | -7,131 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 83,130 | 123,242 | +40,112 | 0.00 | 0.01 | +0.00 | buy |
| Allostery Investments LP | 266,099 | 120,119 | -145,980 | 1.36 | 9.81 | +8.45 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,470,925 | 110,846 | -1,360,079 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 0 | 100,576 | +100,576 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Informed Momentum Co LLC | 0 | 99,960 | +99,960 | 0.00 | 0.10 | +0.10 | buy |
| AMERIPRISE FINANCIAL INC | 12,805 | 95,219 | +82,414 | 0.00 | 0.00 | +0.00 | buy |
| Kennondale Capital Management LLC | 202,743 | 95,165 | -107,578 | 0.78 | 0.62 | -0.16 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57,700 | 91,392 | +33,692 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 54,069 | 87,989 | +33,920 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 83,236 | 56,831 | -26,405 | 0.01 | 0.01 | +0.00 | sell |
| CANTOR FITZGERALD, L. P. | 100,000 | 50,000 | -50,000 | 0.01 | 0.01 | -0.01 | sell |
| Mariner, LLC | 50,906 | 48,668 | -2,238 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 0 | 47,800 | +47,800 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 28,222 | 45,464 | +17,242 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 0 | 42,929 | +42,929 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 75,849 | 40,643 | -35,206 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 38,101 | +38,101 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 37,987 | +37,987 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 36,315 | +36,315 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 37,796 | 35,752 | -2,044 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 0 | 34,153 | +34,153 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 463,240 | 31,098 | -432,142 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 12,744 | 29,430 | +16,686 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 25,999 | +25,999 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 43,234 | 25,856 | -17,378 | 0.01 | 0.01 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 155,700 | 25,700 | -130,000 | 0.01 | 0.00 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 23,320 | +23,320 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 21,900 | +21,900 | 0.00 | 0.00 | +0.00 | buy |
| PARSONS CAPITAL MANAGEMENT INC/RI | 21,645 | 21,645 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 21,756 | 21,123 | -633 | 0.00 | 0.00 | +0.00 | sell |
| Premier Path Wealth Partners, LLC | 20,265 | 20,265 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Marex Group plc | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 19,930 | 19,930 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 19,476 | +19,476 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,188 | 17,904 | +716 | 0.01 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 17,551 | +17,551 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 15,992 | +15,992 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,200 | 15,620 | +420 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,428 | 12,073 | -21,355 | 0.00 | 0.00 | -0.00 | sell |
| Valeo Financial Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 6,803 | 7,467 | +664 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 7,402 | +7,402 | 0.00 | 0.00 | +0.00 | buy |