| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,697,605 | 8,800,000 | +3,102,395 | 0.04 | 0.10 | +0.06 | buy |
| Saturn V Capital Management LP | 2,426,436 | 3,260,570 | +834,134 | 4.33 | 8.47 | +4.14 | buy |
| GREAT POINT PARTNERS LLC | 1,811,996 | 2,000,000 | +188,004 | 3.40 | 8.34 | +4.94 | buy |
| Rock Springs Capital Management LP | 343,228 | 499,764 | +156,536 | 0.07 | 0.20 | +0.13 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 155,700 | 25,700 | +130,000 | 0.01 | 0.00 | 0.00 | sell |
| Alpha Wave Global, LP | 187,311 | 275,842 | +88,531 | 0.30 | 0.19 | -0.10 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,199,691 | 1,154,485 | +45,206 | 0.02 | 0.03 | +0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 7,874,348 | 7,902,365 | +28,017 | 0.98 | 1.88 | +0.89 | buy |
| Quadrature Capital Ltd | 12,744 | 29,430 | +16,686 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,188 | 17,904 | +716 | 0.01 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 83,236 | 56,831 | -26,405 | 0.01 | 0.01 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 348,000 | 313,200 | -34,800 | 0.03 | 0.05 | +0.02 | sell |
| Aldebaran Capital, LLC | 259,253 | 217,827 | -41,426 | 0.87 | 1.38 | +0.51 | sell |
| CANTOR FITZGERALD, L. P. | 100,000 | 50,000 | -50,000 | 0.01 | 0.01 | -0.00 | sell |
| PFM Health Sciences, LP | 834,135 | 732,256 | -101,879 | 0.21 | 0.40 | +0.19 | sell |
| Kennondale Capital Management LLC | 202,743 | 95,165 | -107,578 | 0.78 | 0.62 | -0.16 | sell |
| Allostery Investments LP | 266,099 | 120,119 | -145,980 | 1.36 | 9.81 | +8.45 | sell |
| 683 Capital Management, LLC | 2,411,400 | 2,160,000 | -251,400 | 0.59 | 0.91 | +0.32 | sell |
| ADAR1 Capital Management, LLC | 1,471,587 | 1,205,101 | -266,486 | 1.00 | 1.25 | +0.25 | sell |
| Woodline Partners LP | 1,609,447 | 1,200,290 | -409,157 | 0.04 | 0.04 | +0.00 | sell |
| Boxer Capital Management, LLC | 1,750,000 | 1,225,000 | -525,000 | 1.86 | 3.95 | +2.09 | sell |
| Aberdeen Group plc | 2,430,358 | 738,657 | -1,691,701 | 0.02 | 0.01 | -0.01 | sell |