| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,048,019 | 11,379,207 | +8,331,188 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 7,902,365 | 8,952,365 | +1,050,000 | 1.90 | 3.52 | +1.61 | buy |
| BlackRock, Inc. | 5,510,189 | 7,140,692 | +1,630,503 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,800,000 | 6,816,828 | -1,983,172 | 0.10 | 0.15 | +0.05 | sell |
| TCG Crossover Management, LLC | 5,943,812 | 6,243,812 | +300,000 | 4.35 | 4.17 | -0.18 | buy |
| VANGUARD GROUP INC | 4,498,028 | 5,273,750 | +775,722 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 3,260,570 | 4,604,878 | +1,344,308 | 8.47 | 13.72 | +5.25 | buy |
| Commodore Capital LP | 0 | 4,075,478 | +4,075,478 | 0.00 | 2.70 | +2.70 | buy |
| First Light Asset Management, LLC | 0 | 3,355,882 | +3,355,882 | 0.00 | 4.30 | +4.30 | buy |
| Point72 Asset Management, L.P. | 4,536,266 | 2,790,066 | -1,746,200 | 0.07 | 0.08 | +0.01 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 2,536,233 | +2,536,233 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,264,997 | 2,420,767 | +1,155,770 | 0.06 | 0.24 | +0.17 | buy |
| Almitas Capital LLC | 2,122,597 | 2,122,597 | 0 | 3.43 | 6.60 | +3.17 | hold |
| GOLDMAN SACHS GROUP INC | 1,297,982 | 2,010,633 | +712,651 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 486,893 | 1,950,301 | +1,463,408 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,900,000 | +1,900,000 | 0.00 | 0.76 | +0.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,692,413 | 1,812,039 | +119,626 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 2,160,000 | 1,760,000 | -400,000 | 1.40 | 2.17 | +0.77 | sell |
| GREAT POINT PARTNERS LLC | 2,000,000 | 1,700,000 | -300,000 | 8.34 | 9.65 | +1.31 | sell |
| STATE STREET CORP | 1,008,909 | 1,621,260 | +612,351 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,512,500 | +1,512,500 | 0.00 | 0.34 | +0.34 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,476,302 | +1,476,302 | 0.00 | 0.04 | +0.04 | buy |
| Logos Global Management LP | 0 | 1,450,000 | +1,450,000 | 0.00 | 1.95 | +1.95 | buy |
| UBS Group AG | 1,253,344 | 1,404,471 | +151,127 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 616,919 | 1,365,521 | +748,602 | 0.00 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,198,064 | +1,198,064 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,154,485 | 1,107,008 | -47,477 | 0.03 | 0.05 | +0.02 | sell |
| Nantahala Capital Management, LLC | 2,934,405 | 935,684 | -1,998,721 | 1.33 | 0.79 | -0.55 | sell |
| Boxer Capital Management, LLC | 1,225,000 | 900,000 | -325,000 | 3.95 | 3.90 | -0.05 | sell |
| ADAR1 Capital Management, LLC | 1,205,101 | 866,202 | -338,899 | 1.25 | 1.17 | -0.09 | sell |
| Woodline Partners LP | 1,200,290 | 845,290 | -355,000 | 0.04 | 0.05 | +0.01 | sell |
| NORTHERN TRUST CORP | 820,164 | 822,237 | +2,073 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 586,883 | 810,640 | +223,757 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 313,200 | 750,600 | +437,400 | 0.05 | 0.24 | +0.19 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 700,000 | +700,000 | 0.00 | 1.38 | +1.38 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 588,411 | 645,185 | +56,774 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 612,841 | +612,841 | 0.00 | 0.25 | +0.25 | buy |
| Parkman Healthcare Partners LLC | 650,000 | 579,174 | -70,826 | 0.48 | 0.86 | +0.38 | sell |
| JENNISON ASSOCIATES LLC | 0 | 578,659 | +578,659 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 373,739 | 509,780 | +136,041 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 500,000 | +500,000 | 0.00 | 0.47 | +0.47 | buy |
| Rock Springs Capital Management LP | 499,764 | 499,764 | 0 | 0.20 | 0.40 | +0.20 | hold |
| Ally Bridge Group (NY) LLC | 0 | 437,391 | +437,391 | 0.00 | 4.98 | +4.98 | buy |
| PFM Health Sciences, LP | 732,256 | 436,156 | -296,100 | 0.41 | 0.51 | +0.10 | sell |
| BANK OF AMERICA CORP /DE/ | 451,808 | 429,516 | -22,292 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,512,058 | 417,771 | -1,094,287 | 0.01 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 130,274 | 414,112 | +283,838 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 569,083 | 367,331 | -201,752 | 0.01 | 0.01 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 333,258 | +333,258 | 0.00 | 4.68 | +4.68 | buy |
| Alpha Wave Global, LP | 275,842 | 327,312 | +51,470 | 0.19 | 0.45 | +0.26 | buy |
| Patient Square Capital LP | 0 | 316,312 | +316,312 | 0.00 | 1.15 | +1.15 | buy |
| STEMPOINT CAPITAL LP | 0 | 276,884 | +276,884 | 0.00 | 0.76 | +0.76 | buy |
| TFG Asset Management GP Ltd | 218,750 | 258,242 | +39,492 | 0.25 | 0.51 | +0.26 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 288,618 | 236,197 | -52,421 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 1,242,927 | 234,673 | -1,008,254 | 0.01 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 222,876 | +222,876 | 0.00 | 0.03 | +0.03 | buy |
| FEDERATED HERMES, INC. | 203,930 | 212,379 | +8,449 | 0.00 | 0.01 | +0.00 | buy |
| Aldebaran Capital, LLC | 217,827 | 204,474 | -13,353 | 1.38 | 2.55 | +1.17 | sell |
| Longaeva Partners L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.58 | +0.58 | buy |
| Bank of New York Mellon Corp | 150,837 | 182,956 | +32,119 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 168,000 | +168,000 | 0.00 | 0.09 | +0.09 | buy |
| Qube Research & Technologies Ltd | 438,026 | 167,106 | -270,920 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 164,042 | +164,042 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 155,536 | 160,419 | +4,883 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 143,512 | 143,752 | +240 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 470,000 | 143,000 | -327,000 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 95,219 | 133,508 | +38,289 | 0.00 | 0.00 | +0.00 | buy |
| Kennondale Capital Management LLC | 95,165 | 108,615 | +13,450 | 0.62 | 1.13 | +0.51 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 91,392 | 100,445 | +9,053 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.03 | 0.05 | +0.02 | hold |
| DIADEMA PARTNERS LP | 0 | 100,000 | +100,000 | 0.00 | 0.95 | +0.95 | buy |
| RHUMBLINE ADVISERS | 100,576 | 98,657 | -1,919 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 558,846 | 98,416 | -460,430 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 38,101 | 93,691 | +55,590 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 93,012 | +93,012 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 86,795 | +86,795 | 0.00 | 0.03 | +0.03 | buy |
| Informed Momentum Co LLC | 99,960 | 75,111 | -24,849 | 0.10 | 0.12 | +0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 73,640 | +73,640 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 30,600 | 71,500 | +40,900 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 70,000 | +70,000 | 0.00 | 0.18 | +0.18 | buy |
| D. E. Shaw & Co., Inc. | 151,502 | 68,877 | -82,625 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 7,402 | 67,212 | +59,810 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 0 | 67,153 | +67,153 | 0.00 | 0.13 | +0.13 | buy |
| Verition Fund Management LLC | 0 | 63,896 | +63,896 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 59,132 | +59,132 | 0.00 | 0.04 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 56,667 | +56,667 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 6,229 | 55,406 | +49,177 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 170,533 | 52,107 | -118,426 | 0.08 | 0.06 | -0.02 | sell |
| Mariner, LLC | 48,668 | 48,027 | -641 | 0.00 | 0.00 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 56,831 | 47,898 | -8,933 | 0.01 | 0.02 | +0.01 | sell |
| Schonfeld Strategic Advisors LLC | 646,443 | 43,637 | -602,806 | 0.03 | 0.00 | -0.03 | sell |
| MetLife Investment Management, LLC | 42,929 | 42,929 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 0 | 40,966 | +40,966 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31,098 | 38,083 | +6,985 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 87,989 | 35,844 | -52,145 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,987 | 31,999 | -5,988 | 0.00 | 0.00 | +0.00 | sell |
| Monashee Investment Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.20 | +0.20 | buy |
| Quadrature Capital Ltd | 29,430 | 28,286 | -1,144 | 0.00 | 0.00 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 35,752 | 24,899 | -10,853 | 0.00 | 0.00 | +0.00 | sell |
| Campbell & CO Investment Adviser LLC | 0 | 24,482 | +24,482 | 0.00 | 0.03 | +0.03 | buy |