| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 4,075,478 | 5,650,000 | +1,574,522 | 2.70 | 4.54 | +1.84 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,420,767 | 3,109,503 | +688,736 | 0.24 | 0.26 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 276,884 | 565,140 | +288,256 | 0.76 | 1.17 | +0.41 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,107,008 | 1,004,021 | +102,987 | 0.05 | 0.03 | -0.02 | sell |
| SummitTX Capital, L.P. | 168,000 | 218,399 | +50,399 | 0.09 | 0.08 | -0.01 | buy |
| GREAT POINT PARTNERS LLC | 1,700,000 | 1,750,000 | +50,000 | 9.53 | 6.85 | -2.67 | buy |
| Numerai GP LLC | 67,153 | 112,648 | +45,495 | 0.13 | 0.16 | +0.04 | buy |
| Patient Square Capital LP | 316,312 | 350,000 | +33,688 | 1.15 | 0.91 | -0.24 | buy |
| ADAR1 Capital Management, LLC | 866,202 | 890,356 | +24,154 | 1.17 | 0.80 | -0.36 | buy |
| GSA CAPITAL PARTNERS LLP | 52,107 | 36,758 | +15,349 | 0.07 | 0.04 | 0.00 | sell |
| TFG Asset Management GP Ltd | 258,242 | 272,828 | +14,586 | 0.47 | 0.69 | +0.23 | buy |
| Persistent Asset Partners Ltd | 22,913 | 31,147 | +8,234 | 0.23 | 0.18 | -0.04 | buy |
| Valeo Financial Advisors, LLC | 10,000 | 15,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,630 | 17,895 | +2,265 | 0.02 | 0.02 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,401 | 12,226 | +1,825 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,512,500 | 1,513,148 | +648 | 0.34 | 0.29 | -0.05 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,918 | 2,158 | +240 | 0.00 | 0.00 | -0.00 | buy |
| First Light Asset Management, LLC | 3,355,882 | 3,355,539 | -343 | 4.30 | 3.10 | -1.20 | sell |
| Aldebaran Capital, LLC | 204,474 | 198,508 | -5,966 | 2.55 | 2.15 | -0.40 | sell |
| EntryPoint Capital, LLC | 17,166 | 10,487 | -6,679 | 0.09 | 0.05 | -0.04 | sell |
| Alpha Wave Global, LP | 327,312 | 317,678 | -9,634 | 0.45 | 0.47 | +0.02 | sell |
| Informed Momentum Co LLC | 75,111 | 53,256 | -21,855 | 0.12 | 0.07 | -0.05 | sell |
| Kennondale Capital Management LLC | 108,615 | 53,423 | -55,192 | 1.13 | 0.47 | -0.66 | sell |
| Boxer Capital Management, LLC | 900,000 | 800,000 | -100,000 | 3.90 | 2.12 | -1.78 | sell |
| Cormorant Asset Management, LP | 500,000 | 400,000 | -100,000 | 0.47 | 0.22 | -0.25 | sell |
| Nantahala Capital Management, LLC | 935,684 | 835,684 | -100,000 | 0.44 | 0.33 | -0.11 | sell |
| Saturn V Capital Management LP | 4,604,878 | 4,496,487 | -108,391 | 13.72 | 9.97 | -3.76 | sell |
| 683 Capital Management, LLC | 1,760,000 | 1,650,000 | -110,000 | 1.25 | 0.87 | -0.38 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 700,000 | 506,242 | -193,758 | 1.38 | 0.88 | -0.49 | sell |
| Parkman Healthcare Partners LLC | 579,174 | 381,760 | -197,414 | 0.86 | 0.44 | -0.43 | sell |
| PFM Health Sciences, LP | 436,156 | 134,549 | -301,607 | 0.46 | 0.16 | -0.29 | sell |
| Logos Global Management LP | 1,450,000 | 950,000 | -500,000 | 1.95 | 0.76 | -1.18 | sell |
| PERCEPTIVE ADVISORS LLC | 8,952,365 | 8,284,882 | -667,483 | 3.51 | 1.78 | -1.73 | sell |
| T. Rowe Price Investment Management, Inc. | 1,198,064 | 4,517 | -1,193,547 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,816,828 | 2,777,055 | -4,039,773 | 0.15 | 0.05 | -0.10 | sell |