| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 11,379,207 | 16,518,419 | +5,139,212 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 7,140,692 | 9,054,431 | +1,913,739 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 8,952,365 | 8,284,882 | -667,483 | 3.52 | 1.83 | -1.68 | sell |
| TCG Crossover Management, LLC | 6,243,812 | 6,243,812 | 0 | 4.17 | 2.50 | -1.68 | hold |
| VANGUARD GROUP INC | 5,273,750 | 5,804,912 | +531,162 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 4,075,478 | 5,650,000 | +1,574,522 | 2.70 | 4.54 | +1.84 | buy |
| Saturn V Capital Management LP | 4,604,878 | 4,496,487 | -108,391 | 13.72 | 9.97 | -3.76 | sell |
| JANUS HENDERSON GROUP PLC | 2,536,233 | 4,465,872 | +1,929,639 | 0.02 | 0.02 | +0.01 | buy |
| First Light Asset Management, LLC | 3,355,882 | 3,355,539 | -343 | 4.30 | 3.10 | -1.20 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,420,767 | 3,109,503 | +688,736 | 0.24 | 0.26 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,816,828 | 2,777,055 | -4,039,773 | 0.15 | 0.05 | -0.10 | sell |
| GOLDMAN SACHS GROUP INC | 2,010,633 | 2,613,221 | +602,588 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,950,301 | 2,359,824 | +409,523 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,812,039 | 2,165,534 | +353,495 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 2,122,597 | 2,122,597 | 0 | 6.60 | 5.65 | -0.96 | hold |
| STATE STREET CORP | 1,621,260 | 2,069,884 | +448,624 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,700,000 | 1,750,000 | +50,000 | 9.65 | 6.85 | -2.79 | buy |
| 683 Capital Management, LLC | 1,760,000 | 1,650,000 | -110,000 | 2.17 | 1.66 | -0.52 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,512,500 | 1,513,148 | +648 | 0.34 | 0.29 | -0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 429,516 | 1,336,010 | +906,494 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,365,521 | 1,333,236 | -32,285 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 1,200,096 | +1,200,096 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,107,008 | 1,004,021 | -102,987 | 0.05 | 0.03 | -0.02 | sell |
| Logos Global Management LP | 1,450,000 | 950,000 | -500,000 | 1.95 | 0.76 | -1.18 | sell |
| NORTHERN TRUST CORP | 822,237 | 937,764 | +115,527 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 866,202 | 890,356 | +24,154 | 1.17 | 0.80 | -0.36 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,476,302 | 858,684 | -617,618 | 0.04 | 0.02 | -0.02 | sell |
| Woodline Partners LP | 845,290 | 845,408 | +118 | 0.05 | 0.04 | -0.01 | buy |
| Nantahala Capital Management, LLC | 935,684 | 835,684 | -100,000 | 0.79 | 0.60 | -0.18 | sell |
| Boxer Capital Management, LLC | 900,000 | 800,000 | -100,000 | 3.90 | 2.12 | -1.78 | sell |
| DIMENSIONAL FUND ADVISORS LP | 509,780 | 771,248 | +261,468 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 645,185 | 712,990 | +67,805 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 276,884 | 565,140 | +288,256 | 0.76 | 1.17 | +0.41 | buy |
| UBS Group AG | 1,404,471 | 543,323 | -861,148 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 0 | 527,099 | +527,099 | 0.00 | 0.27 | +0.27 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 700,000 | 506,242 | -193,758 | 1.38 | 0.88 | -0.49 | sell |
| AMERIPRISE FINANCIAL INC | 133,508 | 502,366 | +368,858 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 499,764 | 499,764 | 0 | 0.40 | 0.31 | -0.09 | hold |
| FEDERATED HERMES, INC. | 212,379 | 457,412 | +245,033 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 167,106 | 412,873 | +245,767 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 500,000 | 400,000 | -100,000 | 0.47 | 0.27 | -0.19 | sell |
| Parkman Healthcare Partners LLC | 579,174 | 381,760 | -197,414 | 0.86 | 0.44 | -0.43 | sell |
| Patient Square Capital LP | 316,312 | 350,000 | +33,688 | 1.15 | 0.91 | -0.24 | buy |
| CITADEL ADVISORS LLC | 234,673 | 344,968 | +110,295 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 98,416 | 344,401 | +245,985 | 0.00 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,790,066 | 335,000 | -2,455,066 | 0.08 | 0.01 | -0.08 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 333,258 | 333,258 | 0 | 4.68 | 2.73 | -1.95 | hold |
| TWO SIGMA ADVISERS, LP | 143,000 | 328,401 | +185,401 | 0.00 | 0.01 | +0.00 | buy |
| Alpha Wave Global, LP | 327,312 | 317,678 | -9,634 | 0.45 | 0.47 | +0.02 | sell |
| BARCLAYS PLC | 414,112 | 295,177 | -118,935 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 160,419 | 283,948 | +123,529 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 258,242 | 272,828 | +14,586 | 0.51 | 0.69 | +0.19 | buy |
| JANE STREET GROUP, LLC | 0 | 263,235 | +263,235 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 367,331 | 254,328 | -113,003 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 238,812 | +238,812 | 0.00 | 0.74 | +0.74 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 236,197 | 225,782 | -10,415 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 168,000 | 218,399 | +50,399 | 0.09 | 0.08 | -0.01 | buy |
| Bank of New York Mellon Corp | 182,956 | 217,347 | +34,391 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 204,474 | 198,508 | -5,966 | 2.55 | 2.15 | -0.40 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 19,900 | 192,500 | +172,600 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 189,673 | +189,673 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 810,640 | 175,914 | -634,726 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 161,700 | +161,700 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 153,363 | +153,363 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 93,691 | 146,309 | +52,618 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 139,422 | +139,422 | 0.00 | 0.13 | +0.13 | buy |
| BANK OF MONTREAL /CAN/ | 143,752 | 138,525 | -5,227 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 436,156 | 134,549 | -301,607 | 0.51 | 0.16 | -0.34 | sell |
| Numerai GP LLC | 67,153 | 112,648 | +45,495 | 0.13 | 0.16 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 100,445 | 107,548 | +7,103 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 98,657 | 99,274 | +617 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 98,838 | +98,838 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 90,172 | +90,172 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,875 | 84,144 | +70,269 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,331 | 79,090 | +74,759 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 24,482 | 78,763 | +54,281 | 0.03 | 0.05 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 76,562 | +76,562 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 68,877 | 73,224 | +4,347 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 67,212 | 72,612 | +5,400 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 71,500 | 71,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 68,892 | +68,892 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 35,844 | 66,547 | +30,703 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 55,406 | 65,438 | +10,032 | 0.00 | 0.00 | +0.00 | buy |
| Kennondale Capital Management LLC | 108,615 | 53,423 | -55,192 | 1.13 | 0.47 | -0.66 | sell |
| Informed Momentum Co LLC | 75,111 | 53,256 | -21,855 | 0.12 | 0.07 | -0.05 | sell |
| SEI INVESTMENTS CO | 0 | 52,856 | +52,856 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,929 | 49,654 | +6,725 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 222,876 | 48,112 | -174,764 | 0.03 | 0.01 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 417,771 | 46,455 | -371,316 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 48,027 | 46,342 | -1,685 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,999 | 41,166 | +9,167 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 38,083 | 38,032 | -51 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 52,107 | 36,758 | -15,349 | 0.06 | 0.04 | -0.02 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,906 | 35,877 | +33,971 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 35,409 | +35,409 | 0.00 | 0.07 | +0.07 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,494 | 32,006 | +12,512 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 22,913 | 31,147 | +8,234 | 0.23 | 0.18 | -0.04 | buy |
| Headlands Technologies LLC | 0 | 30,543 | +30,543 | 0.00 | 0.03 | +0.03 | buy |
| Verition Fund Management LLC | 63,896 | 29,487 | -34,409 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 73,640 | 27,847 | -45,793 | 0.00 | 0.00 | -0.00 | sell |