| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 2,252,987 | +2,252,987 | 0.00 | 0.70 | +0.70 | buy |
| Atlas Venture Life Science Advisors, LLC | 0 | 2,092,106 | +2,092,106 | 0.00 | 3.29 | +3.29 | buy |
| Carlyle Group Inc. | 0 | 1,102,741 | +1,102,741 | 0.00 | 1.14 | +1.14 | buy |
| Vivo Capital, LLC | 0 | 370,068 | +370,068 | 0.00 | 0.50 | +0.50 | buy |
| ARCH Venture Management, LLC | 0 | 320,482 | +320,482 | 0.00 | 6.80 | +6.80 | buy |
| Temasek Holdings (Private) Ltd | 0 | 313,943 | +313,943 | 0.00 | 0.03 | +0.03 | buy |
| 5AM Venture Management, LLC | 0 | 251,994 | +251,994 | 0.00 | 0.96 | +0.96 | buy |
| ADAR1 Capital Management, LLC | 0 | 187,567 | +187,567 | 0.00 | 0.87 | +0.87 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 109,964 | +109,964 | 0.00 | 0.08 | +0.08 | buy |
| VANGUARD GROUP INC | 0 | 107,752 | +107,752 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 65,021 | +65,021 | 0.00 | 0.95 | +0.95 | buy |
| Erste Asset Management GmbH | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 27,777 | +27,777 | 0.00 | 0.08 | +0.08 | buy |
| Ensign Peak Advisors, Inc | 0 | 25,731 | +25,731 | 0.00 | 0.00 | +0.00 | buy |
| BML Capital Management, LLC | 0 | 24,894 | +24,894 | 0.00 | 0.28 | +0.28 | buy |
| Ikarian Capital, LLC | 0 | 22,335 | +22,335 | 0.00 | 0.10 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 17,966 | +17,966 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 15,584 | +15,584 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 15,133 | +15,133 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 0 | 10,061 | +10,061 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,695 | +3,695 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 3,513 | +3,513 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 2,983 | +2,983 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorNet Financial, Inc | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| ST GERMAIN D J CO INC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| THOMPSON INVESTMENT MANAGEMENT, INC. | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |