| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 213,363 | 1,256,228 | +1,042,865 | 0.09 | 1.06 | +0.97 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 246,304 | +246,304 | 0.00 | 0.00 | +0.00 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 0 | 134,310 | +134,310 | 0.00 | 0.24 | +0.24 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 48,373 | 172,586 | +124,213 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 99,600 | 206,915 | +107,315 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 65,599 | +65,599 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 52,440 | +52,440 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 35,025 | +35,025 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 59,932 | 86,147 | +26,215 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 20,695 | +20,695 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 21,237 | 41,514 | +20,277 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 18,770 | +18,770 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,000 | 35,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 12,613 | +12,613 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 106,113 | 118,152 | +12,039 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 976 | 1,871 | +895 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 30 | 111 | +81 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 1,111 | 1,148 | +37 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,364 | 3,400 | +36 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,252,987 | 2,252,987 | 0 | 0.15 | 0.32 | +0.16 | hold |
| FEDERATED HERMES, INC. | 2,273 | 2,273 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sanofi | 244,083 | 244,083 | 0 | 0.26 | 0.47 | +0.21 | hold |
| ARCH Venture Management, LLC | 320,482 | 320,482 | 0 | 0.16 | 0.30 | +0.14 | hold |
| AdvisorNet Financial, Inc | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,102,741 | 1,102,741 | 0 | 0.03 | 0.07 | +0.04 | hold |
| Allworth Financial LP | 98 | 98 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 454 | 454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 4,640 | 4,640 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 577 | 577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 27,777 | 27,777 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 2,092,106 | 0 | 0.80 | 1.70 | +0.90 | hold |
| Federation des caisses Desjardins du Quebec | 70 | 70 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 25,033 | 25,033 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 34 | 34 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 166 | 166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 308 | 303 | -5 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 19 | 0 | -19 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 157 | 104 | -53 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 46,825 | 42,346 | -4,479 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 15,510 | 0 | -15,510 | 0.03 | 0.00 | -0.03 | sell |
| XTX Topco Ltd | 20,353 | 0 | -20,353 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 24,698 | 0 | -24,698 | 0.00 | 0.00 | -0.00 | sell |
| Monaco Asset Management SAM | 50,919 | 0 | -50,919 | 0.05 | 0.00 | -0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 51,268 | 0 | -51,268 | 0.00 | 0.00 | -0.00 | sell |
| PFIZER INC | 277,777 | 101,618 | -176,159 | 0.39 | 0.31 | -0.08 | sell |
| ACORN CAPITAL ADVISORS, LLC | 493,425 | 315,052 | -178,373 | 0.56 | 0.57 | +0.02 | sell |