| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 3,513 | 179,638 | +176,125 | 0.00 | 0.00 | +0.00 | buy |
| HARVARD MANAGEMENT CO INC | 0 | 162,965 | +162,965 | 0.00 | 0.18 | +0.18 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 17,966 | 107,654 | +89,688 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 22,335 | 109,094 | +86,759 | 0.10 | 0.61 | +0.51 | buy |
| STATE STREET CORP | 0 | 81,299 | +81,299 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 25,731 | 64,481 | +38,750 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 107,752 | 138,367 | +30,615 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 29,575 | +29,575 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 17,569 | +17,569 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 15,410 | +15,410 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,764 | +14,764 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 13,291 | +13,291 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 12,000 | +12,000 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 11,942 | +11,942 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 10,061 | 18,119 | +8,058 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 65 | 7,658 | +7,593 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,600 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 2,727 | +2,727 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,202 | +2,202 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,983 | 5,090 | +2,107 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,354 | +1,354 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 591 | +591 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 523 | +523 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 511 | +511 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 437 | +437 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 434 | +434 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 209 | +209 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 313,943 | 313,943 | 0 | 0.03 | 0.03 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 2,252,987 | 2,252,987 | 0 | 0.70 | 0.80 | +0.10 | hold |
| ARCH Venture Management, LLC | 320,482 | 320,482 | 0 | 6.80 | 2.16 | -4.64 | hold |
| THOMPSON INVESTMENT MANAGEMENT, INC. | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,102,741 | 1,102,741 | 0 | 1.14 | 1.82 | +0.68 | hold |
| BFSG, LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 27,777 | 27,777 | 0 | 0.08 | 0.08 | +0.00 | hold |
| 5AM Venture Management, LLC | 251,994 | 251,994 | 0 | 0.96 | 1.01 | +0.05 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 2,092,106 | 0 | 3.29 | 3.95 | +0.66 | hold |
| Federation des caisses Desjardins du Quebec | 39 | 39 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ST GERMAIN D J CO INC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 25 | 22 | -3 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorNet Financial, Inc | 45 | 13 | -32 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 3,695 | 0 | -3,695 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,133 | 0 | -15,133 | 0.02 | 0.00 | -0.02 | sell |
| Woodline Partners LP | 15,584 | 0 | -15,584 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 109,964 | 89,456 | -20,508 | 0.08 | 0.06 | -0.01 | sell |
| Exome Asset Management LLC | 65,021 | 43,865 | -21,156 | 0.95 | 0.70 | -0.25 | sell |
| BML Capital Management, LLC | 24,894 | 0 | -24,894 | 0.28 | 0.00 | -0.28 | sell |
| ADAR1 Capital Management, LLC | 187,567 | 156,504 | -31,063 | 0.87 | 0.57 | -0.31 | sell |
| Vivo Capital, LLC | 370,068 | 20,559 | -349,509 | 0.50 | 0.03 | -0.46 | sell |