| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Boxer Capital Management, LLC | 0 | 3,149,310 | +3,149,310 | 0.00 | 3.02 | +3.02 | buy |
| BVF INC/IL | 0 | 2,350,000 | +2,350,000 | 0.00 | 0.77 | +0.77 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,332,457 | +2,332,457 | 0.00 | 0.26 | +0.26 | buy |
| ORBIMED ADVISORS LLC | 2,252,987 | 4,127,987 | +1,875,000 | 0.32 | 1.00 | +0.68 | buy |
| Point72 Asset Management, L.P. | 0 | 1,173,396 | +1,173,396 | 0.00 | 0.02 | +0.02 | buy |
| Logos Global Management LP | 0 | 800,000 | +800,000 | 0.00 | 0.44 | +0.44 | buy |
| SummitTX Capital, L.P. | 0 | 733,774 | +733,774 | 0.00 | 0.25 | +0.25 | buy |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 2,717,106 | +625,000 | 1.70 | 3.93 | +2.23 | buy |
| Ikarian Capital, LLC | 0 | 430,000 | +430,000 | 0.00 | 0.90 | +0.90 | buy |
| Woodline Partners LP | 0 | 286,212 | +286,212 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,770 | 272,752 | +253,982 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 130,427 | +130,427 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 0 | 120,663 | +120,663 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 65,599 | 162,747 | +97,148 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 172,586 | 218,234 | +45,648 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 36,396 | +36,396 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 32,896 | +32,896 | 0.00 | 0.08 | +0.08 | buy |
| BlackRock, Inc. | 86,147 | 118,507 | +32,360 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 30,412 | +30,412 | 0.00 | 0.20 | +0.20 | buy |
| Squarepoint Ops LLC | 0 | 23,790 | +23,790 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 23,588 | +23,588 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 22,150 | +22,150 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,613 | 34,613 | +22,000 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 15,949 | +15,949 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 52,440 | 67,045 | +14,605 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 12,342 | +12,342 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 11,336 | +11,336 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 10,928 | +10,928 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,874 | +10,874 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 41,514 | 52,214 | +10,700 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 42,346 | 49,582 | +7,236 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 118,152 | 122,690 | +4,538 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 2,888 | +2,888 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Asset Management, LLC | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 98 | 108 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Sanofi | 244,083 | 244,083 | 0 | 0.47 | 0.58 | +0.12 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 303 | 303 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AdvisorNet Financial, Inc | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 577 | 577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 27,777 | 27,777 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Federation des caisses Desjardins du Quebec | 70 | 70 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 34 | 34 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 166 | 166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 104 | 94 | -10 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 3,400 | 3,388 | -12 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 1,148 | 1,111 | -37 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 0 | -111 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 454 | 0 | -454 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,273 | 1,050 | -1,223 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 25,033 | 23,631 | -1,402 | 0.00 | 0.00 | +0.00 | sell |
| Global Retirement Partners, LLC | 1,500 | 0 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,871 | 0 | -1,871 | 0.00 | 0.00 | -0.00 | sell |
| MONIMUS CAPITAL MANAGEMENT, LP | 134,310 | 132,036 | -2,274 | 0.24 | 0.43 | +0.19 | sell |
| EverSource Wealth Advisors, LLC | 4,640 | 240 | -4,400 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 35,025 | 18,081 | -16,944 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 20,695 | 0 | -20,695 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 206,915 | 179,600 | -27,315 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 35,000 | 0 | -35,000 | 0.01 | 0.00 | -0.01 | sell |
| ACORN CAPITAL ADVISORS, LLC | 315,052 | 216,171 | -98,881 | 0.57 | 0.75 | +0.18 | sell |
| PFIZER INC | 101,618 | 0 | -101,618 | 0.31 | 0.00 | -0.31 | sell |
| MACKENZIE FINANCIAL CORP | 246,304 | 0 | -246,304 | 0.00 | 0.00 | -0.00 | sell |
| ARCH Venture Management, LLC | 320,482 | 0 | -320,482 | 0.30 | 0.00 | -0.30 | sell |
| Opaleye Management Inc. | 1,256,228 | 931,000 | -325,228 | 1.06 | 1.07 | +0.01 | sell |
| Carlyle Group Inc. | 1,102,741 | 60,363 | -1,042,378 | 0.07 | 0.01 | -0.06 | sell |