| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 404,411 | +404,411 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 179,638 | 426,302 | +246,664 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 190,000 | +190,000 | 0.00 | 0.15 | +0.15 | buy |
| VANGUARD GROUP INC | 138,367 | 285,416 | +147,049 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 106,901 | +106,901 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 100,343 | +100,343 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 76,685 | +76,685 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 0 | 61,255 | +61,255 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 30,000 | 60,000 | +30,000 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 81,299 | 110,164 | +28,865 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 107,654 | 131,768 | +24,114 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 16,437 | +16,437 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 12,703 | +12,703 | 0.00 | 0.08 | +0.08 | buy |
| Trexquant Investment LP | 0 | 7,790 | +7,790 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 5,090 | 10,443 | +5,353 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 4,857 | +4,857 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 4,705 | +4,705 | 0.00 | 0.06 | +0.06 | buy |
| JPMORGAN CHASE & CO | 0 | 3,688 | +3,688 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 3,642 | +3,642 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 3,563 | +3,563 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 3,311 | +3,311 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 3,128 | +3,128 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,354 | 4,391 | +3,037 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,764 | 16,164 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 12,000 | 13,229 | +1,229 | 0.01 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 434 | 1,298 | +864 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 741 | +741 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 7,658 | 8,348 | +690 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 11,942 | 12,434 | +492 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 131 | +131 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 108 | +108 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,727 | 2,779 | +52 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 31 | +31 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 5 | +5 | 0.00 | 0.00 | 0.00 | buy |
| Temasek Holdings (Private) Ltd | 313,943 | 313,943 | 0 | 0.03 | 0.06 | +0.03 | hold |
| ORBIMED ADVISORS LLC | 2,252,987 | 2,252,987 | 0 | 0.80 | 1.84 | +1.04 | hold |
| Ameritas Investment Partners, Inc. | 591 | 591 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 437 | 437 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARVARD MANAGEMENT CO INC | 162,965 | 162,965 | 0 | 0.18 | 0.42 | +0.24 | hold |
| ARCH Venture Management, LLC | 320,482 | 320,482 | 0 | 2.16 | 5.49 | +3.33 | hold |
| THOMPSON INVESTMENT MANAGEMENT, INC. | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AdvisorNet Financial, Inc | 13 | 13 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 64,481 | 64,481 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Carlyle Group Inc. | 1,102,741 | 1,102,741 | 0 | 1.82 | 5.10 | +3.27 | hold |
| Vivo Capital, LLC | 20,559 | 20,559 | 0 | 0.03 | 0.08 | +0.04 | hold |
| BFSG, LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 27,777 | 27,777 | 0 | 0.08 | 0.19 | +0.11 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 2,092,106 | 0 | 3.95 | 8.65 | +4.70 | hold |
| Legal & General Group Plc | 523 | 523 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ST GERMAIN D J CO INC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,410 | 15,410 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 209 | 209 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 39 | 38 | -1 | 0.00 | 0.00 | +0.00 | sell |
| Global Retirement Partners, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 3,244 | 3,223 | -21 | 0.00 | 0.00 | +0.00 | sell |
| NewEdge Advisors, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| Redwood Wealth Management Group, LLC | 511 | 0 | -511 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 13,291 | 11,445 | -1,846 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,202 | 192 | -2,010 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 17,569 | 15,042 | -2,527 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,600 | 2,400 | -4,200 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 18,119 | 0 | -18,119 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 89,456 | 66,801 | -22,655 | 0.06 | 0.13 | +0.07 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 29,575 | 0 | -29,575 | 0.02 | 0.00 | -0.02 | sell |
| Exome Asset Management LLC | 43,865 | 0 | -43,865 | 0.70 | 0.00 | -0.70 | sell |
| ADAR1 Capital Management, LLC | 156,504 | 64,245 | -92,259 | 0.57 | 0.48 | -0.09 | sell |
| Ikarian Capital, LLC | 109,094 | 0 | -109,094 | 0.61 | 0.00 | -0.61 | sell |
| 5AM Venture Management, LLC | 251,994 | 0 | -251,994 | 1.01 | 0.00 | -1.01 | sell |