| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 0 | 213,363 | +213,363 | 0.00 | 0.09 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 47,300 | 99,600 | +52,300 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 295,409 | 321,051 | +25,642 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 20,353 | +20,353 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 29,739 | 48,373 | +18,634 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 88,496 | 106,113 | +17,617 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 15,510 | +15,510 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 31,506 | 46,825 | +15,319 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 14,836 | 24,698 | +9,862 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,252,987 | 2,252,987 | 0 | 0.11 | 0.15 | +0.05 | hold |
| Sanofi | 244,083 | 244,083 | 0 | 0.19 | 0.26 | +0.08 | hold |
| ARCH Venture Management, LLC | 320,482 | 320,482 | 0 | 0.13 | 0.16 | +0.03 | hold |
| AdvisorNet Financial, Inc | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carlyle Group Inc. | 1,102,741 | 1,102,741 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Russell Investments Group, Ltd. | 454 | 454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 577 | 577 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 27,777 | 27,777 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,092,106 | 2,092,106 | 0 | 0.55 | 0.80 | +0.25 | hold |
| Federation des caisses Desjardins du Quebec | 70 | 70 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFIZER INC | 277,777 | 277,777 | 0 | 0.13 | 0.39 | +0.26 | hold |
| HARBOUR INVESTMENTS, INC. | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 34 | 34 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 21,237 | 21,237 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 166 | 166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ST GERMAIN D J CO INC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,374 | 2,273 | -101 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 1,215 | 1,111 | -104 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 432 | 308 | -124 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 227 | 0 | -227 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 236 | 0 | -236 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 5,025 | 4,640 | -385 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 472 | 0 | -472 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 610 | 98 | -512 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 822 | 19 | -803 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,138 | 0 | -2,138 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 5,000 | 1,500 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,482 | 976 | -5,506 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 31,953 | 25,033 | -6,920 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 8,156 | 157 | -7,999 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 10,333 | 0 | -10,333 | 0.01 | 0.00 | -0.01 | sell |
| FMR LLC | 15,867 | 3,364 | -12,503 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 13,749 | 0 | -13,749 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 93,005 | 59,932 | -33,073 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 104,772 | 51,268 | -53,504 | 0.00 | 0.00 | -0.00 | sell |
| Trustees of Columbia University in the City of New York | 133,903 | 0 | -133,903 | 0.04 | 0.00 | -0.04 | sell |
| Monaco Asset Management SAM | 311,137 | 50,919 | -260,218 | 0.23 | 0.05 | -0.18 | sell |
| ACORN CAPITAL ADVISORS, LLC | 803,425 | 493,425 | -310,000 | 0.81 | 0.56 | -0.25 | sell |