| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 155,373 | 7,153,280 | +6,997,907 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 4,878,000 | 4,878,000 | 0 | 0.43 | 0.51 | +0.08 | hold |
| WASATCH ADVISORS LP | 7,138,949 | 4,328,479 | -2,810,470 | 0.22 | 0.18 | -0.04 | sell |
| Lynx1 Capital Management LP | 3,134,396 | 3,634,662 | +500,266 | 6.96 | 7.65 | +0.69 | buy |
| Commodore Capital LP | 3,800,000 | 3,410,384 | -389,616 | 1.88 | 1.86 | -0.01 | sell |
| VANGUARD GROUP INC | 1,999,401 | 2,920,028 | +920,627 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,835,996 | 2,458,996 | +623,000 | 1.15 | 1.76 | +0.61 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,704,269 | 2,435,380 | +731,111 | 0.03 | 0.05 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,558,480 | 2,115,477 | -443,003 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,675,097 | 1,855,158 | +180,061 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,435,931 | +1,435,931 | 0.00 | 3.29 | +3.29 | buy |
| TWO SIGMA ADVISERS, LP | 72,700 | 1,312,200 | +1,239,500 | 0.00 | 0.02 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 2,137,381 | 1,291,939 | -845,442 | 0.13 | 0.12 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 113,513 | 1,281,242 | +1,167,729 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,276,574 | 1,276,574 | 0 | 0.80 | 0.82 | +0.02 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 1,171,840 | +1,171,840 | 0.00 | 0.02 | +0.02 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,642,210 | 1,142,210 | -500,000 | 0.89 | 0.75 | -0.14 | sell |
| Point72 Asset Management, L.P. | 1,961,359 | 906,472 | -1,054,887 | 0.03 | 0.02 | -0.01 | sell |
| Rafferty Asset Management, LLC | 0 | 833,681 | +833,681 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 135,473 | 770,728 | +635,255 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 311,377 | 764,862 | +453,485 | 0.02 | 0.07 | +0.05 | buy |
| UBS Group AG | 278,375 | 696,677 | +418,302 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 115,508 | 632,091 | +516,583 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 732,145 | 575,131 | -157,014 | 0.00 | 0.00 | +0.00 | sell |
| Laurion Capital Management LP | 0 | 535,342 | +535,342 | 0.00 | 0.12 | +0.12 | buy |
| MORGAN STANLEY | 205,341 | 514,183 | +308,842 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 482,288 | 510,315 | +28,027 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 243,638 | 496,543 | +252,905 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,002,513 | 487,651 | -514,862 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 424,700 | 405,800 | -18,900 | 0.00 | 0.01 | +0.00 | sell |
| Qube Research & Technologies Ltd | 27,090 | 388,193 | +361,103 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 47,214 | 334,518 | +287,304 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 316,246 | +316,246 | 0.00 | 0.32 | +0.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 252,710 | 267,429 | +14,719 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 224,487 | +224,487 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 197,109 | +197,109 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 168,218 | 174,356 | +6,138 | 0.00 | 0.01 | +0.00 | buy |
| BIT Capital GmbH | 0 | 168,090 | +168,090 | 0.00 | 0.12 | +0.12 | buy |
| MARSHALL WACE, LLP | 1,123,061 | 146,644 | -976,417 | 0.01 | 0.00 | -0.01 | sell |
| Man Group plc | 159,765 | 139,900 | -19,865 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 46,025 | 136,827 | +90,802 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 128,037 | 128,037 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PROFUND ADVISORS LLC | 0 | 126,250 | +126,250 | 0.00 | 0.04 | +0.04 | buy |
| Jump Financial, LLC | 0 | 116,507 | +116,507 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 108,677 | 108,678 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 104,367 | +104,367 | 0.00 | 0.02 | +0.02 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 75,794 | 96,964 | +21,170 | 0.08 | 0.10 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 94,400 | 92,800 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 91,127 | 91,127 | 0 | 0.01 | 0.02 | +0.01 | hold |
| AMERICAN CENTURY COMPANIES INC | 34,734 | 88,850 | +54,116 | 0.00 | 0.00 | +0.00 | buy |
| Arete Wealth Advisors, LLC | 72,100 | 85,200 | +13,100 | 0.03 | 0.06 | +0.03 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.22 | 0.27 | +0.05 | hold |
| M&T BANK CORP | 138,588 | 84,810 | -53,778 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 76,791 | +76,791 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 26,329 | 72,218 | +45,889 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 64,001 | +64,001 | 0.00 | 0.09 | +0.09 | buy |
| Marathon Trading Investment Management LLC | 0 | 64,000 | +64,000 | 0.00 | 0.21 | +0.21 | buy |
| Bellevue Group AG | 62,000 | 57,600 | -4,400 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 198,671 | 54,114 | -144,557 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 43,615 | 53,093 | +9,478 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 52,304 | +52,304 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 51,365 | +51,365 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 95,020 | 49,269 | -45,751 | 0.02 | 0.01 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 124,000 | 49,000 | -75,000 | 0.02 | 0.01 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 48,763 | +48,763 | 0.00 | 0.03 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 47,449 | +47,449 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 41,732 | +41,732 | 0.00 | 0.07 | +0.07 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 41,445 | +41,445 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 39,396 | +39,396 | 0.00 | 0.02 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,310 | 39,002 | +22,692 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 692,082 | 38,536 | -653,546 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 37,560 | 37,288 | -272 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 28,590 | +28,590 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 28,516 | +28,516 | 0.00 | 0.21 | +0.21 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 28,000 | +28,000 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 24,794 | +24,794 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 23,850 | +23,850 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 42,554 | 23,604 | -18,950 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 22,368 | +22,368 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 169,416 | 21,993 | -147,423 | 0.00 | 0.00 | -0.00 | sell |
| Polymer Capital Management (HK) LTD | 0 | 21,906 | +21,906 | 0.00 | 0.05 | +0.05 | buy |
| STIFEL FINANCIAL CORP | 0 | 20,012 | +20,012 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 19,563 | +19,563 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 18,317 | +18,317 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 15,526 | +15,526 | 0.00 | 0.01 | +0.01 | buy |
| Entropy Technologies, LP | 0 | 15,391 | +15,391 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 14,822 | 14,822 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 14,753 | 13,238 | -1,515 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 12,695 | 12,695 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quantbot Technologies LP | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 16,322 | 6,913 | -9,409 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 4,009 | +4,009 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 3,929 | +3,929 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,791 | 1,791 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aquatic Capital Management LLC | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| SYNTAX RESEARCH, INC. | 1,000 | 1,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Piscataqua Savings Bank | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 331 | 331 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cape Investment Advisory, Inc. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |