| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 8,981,662 | 9,072,400 | +90,738 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | 8,000,000 | 0 | 0.16 | 0.22 | +0.07 | hold |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | 7,171,910 | 0 | 1.05 | 1.70 | +0.65 | hold |
| Lynx1 Capital Management LP | 7,098,133 | 6,998,902 | -99,231 | 2.74 | 2.91 | +0.16 | sell |
| Soleus Capital Management, L.P. | 3,803,942 | 3,803,942 | 0 | 0.31 | 0.41 | +0.10 | hold |
| JPMORGAN CHASE & CO | 0 | 3,223,054 | +3,223,054 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,509,603 | 3,035,634 | +1,526,031 | 0.00 | 0.01 | +0.00 | buy |
| WASATCH ADVISORS LP | 4,344,918 | 2,961,761 | -1,383,157 | 0.05 | 0.05 | +0.00 | sell |
| CITADEL ADVISORS LLC | 447,808 | 2,511,015 | +2,063,207 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,602,580 | 2,461,815 | +859,235 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,089,020 | 2,387,378 | +1,298,358 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,387,586 | 2,359,241 | -28,345 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 1,969,814 | 2,048,526 | +78,712 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,994,224 | 1,911,785 | -82,439 | 0.55 | 0.59 | +0.04 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 657,173 | 1,890,914 | +1,233,741 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,188,969 | 1,393,342 | +204,373 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,775,783 | 1,286,840 | -488,943 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 874,794 | 1,246,896 | +372,102 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 52,879 | 1,060,331 | +1,007,452 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 988,878 | 951,043 | -37,835 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 809,260 | 867,911 | +58,651 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,404,902 | 856,353 | -548,549 | 0.05 | 0.05 | -0.01 | sell |
| CONGRESS ASSET MANAGEMENT CO | 0 | 830,624 | +830,624 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 290,234 | 752,114 | +461,880 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 453,236 | +453,236 | 0.00 | 0.23 | +0.23 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 449,432 | 452,228 | +2,796 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 296,480 | 442,518 | +146,038 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 384,766 | +384,766 | 0.00 | 0.26 | +0.26 | buy |
| STATE STREET CORP | 342,773 | 382,973 | +40,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 219,204 | 317,877 | +98,673 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 400,000 | 300,000 | -100,000 | 0.06 | 0.07 | +0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 37,721 | 277,183 | +239,462 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 254,406 | 272,368 | +17,962 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 264,620 | +264,620 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 272,053 | 260,279 | -11,774 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 156,098 | 256,468 | +100,370 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 243,305 | 246,800 | +3,495 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 268,350 | 244,507 | -23,843 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 443,341 | 239,118 | -204,223 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 237,137 | 223,168 | -13,969 | 0.02 | 0.02 | +0.00 | sell |
| UBS Group AG | 0 | 215,877 | +215,877 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,161 | 190,348 | +188,187 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 166,207 | 189,479 | +23,272 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 174,663 | +174,663 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 9,439,328 | 169,096 | -9,270,232 | 0.03 | 0.00 | -0.03 | sell |
| HRT FINANCIAL LP | 0 | 162,930 | +162,930 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 265,027 | 155,495 | -109,532 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 104,964 | 136,047 | +31,083 | 0.02 | 0.03 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,500 | 135,600 | +106,100 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 131,100 | 131,100 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Hudson Bay Capital Management LP | 111,551 | 130,081 | +18,530 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 128,050 | 127,517 | -533 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 92,647 | +92,647 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 87,400 | +87,400 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 86,760 | +86,760 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 86,278 | +86,278 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 68,245 | 85,444 | +17,199 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.08 | 0.09 | +0.01 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,400 | 71,546 | +59,146 | 0.00 | 0.00 | +0.00 | buy |
| Crestwood Advisors Group, LLC | 66,536 | 66,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quadrature Capital Ltd | 133,112 | 62,760 | -70,352 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 12,762 | 62,390 | +49,628 | 0.00 | 0.00 | +0.00 | buy |
| INTREPID FAMILY OFFICE LLC | 55,000 | 60,000 | +5,000 | 0.10 | 0.14 | +0.04 | buy |
| OMERS ADMINISTRATION Corp | 117,700 | 59,700 | -58,000 | 0.00 | 0.00 | -0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 49,586 | +49,586 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 62,165 | 47,507 | -14,658 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 104,458 | 47,151 | -57,307 | 0.01 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 43,000 | +43,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 49,840 | 42,428 | -7,412 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 136,054 | 40,664 | -95,390 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 38,187 | 38,187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Diametric Capital, LP | 0 | 34,594 | +34,594 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 30,957 | +30,957 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 35,340 | 26,120 | -9,220 | 0.00 | 0.00 | +0.00 | sell |
| Catalyst Funds Management Pty Ltd | 42,500 | 25,740 | -16,760 | 0.02 | 0.01 | -0.01 | sell |
| SEI INVESTMENTS CO | 0 | 25,134 | +25,134 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WINTON GROUP Ltd | 0 | 24,700 | +24,700 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 23,944 | +23,944 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 102,198 | 23,733 | -78,465 | 0.01 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 23,700 | +23,700 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 21,387 | 21,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Callan Family Office, LLC | 31,743 | 19,146 | -12,597 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 15,792 | 17,316 | +1,524 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 15,050 | 15,950 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 15,224 | 15,249 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Dauntless Investment Group, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.11 | +0.11 | buy |
| EWA, LLC | 16,889 | 14,572 | -2,317 | 0.01 | 0.01 | +0.00 | sell |
| NINE MASTS CAPITAL Ltd | 11,472 | 14,157 | +2,685 | 0.00 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 13,629 | 13,629 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CTC Alternative Strategies, Ltd. | 0 | 10,792 | +10,792 | 0.00 | 0.06 | +0.06 | buy |
| SummitTX Capital, L.P. | 0 | 10,466 | +10,466 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,203 | +10,203 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 10,202 | 10,201 | -1 | 0.00 | 0.00 | +0.00 | sell |
| Ethic Inc. | 10,278 | 10,131 | -147 | 0.00 | 0.00 | +0.00 | sell |
| Abel Hall, LLC | 10,140 | 10,088 | -52 | 0.00 | 0.01 | +0.00 | sell |
| Bronte Capital Management Pty Ltd. | 10,033 | 10,033 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blackston Financial Advisory Group, LLC | 10,000 | 10,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 25,980 | 9,849 | -16,131 | 0.00 | 0.00 | -0.00 | sell |