| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 3,634,662 | 6,880,527 | +3,245,865 | 7.65 | 11.49 | +3.84 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 4,878,000 | 4,878,000 | 0 | 0.51 | 0.30 | -0.21 | hold |
| WASATCH ADVISORS LP | 4,328,479 | 4,847,150 | +518,671 | 0.18 | 0.12 | -0.07 | buy |
| Soleus Capital Management, L.P. | 2,458,996 | 4,051,996 | +1,593,000 | 1.76 | 1.65 | -0.11 | buy |
| VANGUARD GROUP INC | 2,920,028 | 3,556,699 | +636,671 | 0.00 | 0.00 | -0.00 | buy |
| Commodore Capital LP | 3,410,384 | 3,410,384 | 0 | 1.86 | 1.08 | -0.79 | hold |
| STATE STREET CORP | 7,153,280 | 2,994,948 | -4,158,332 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 2,435,380 | 1,936,139 | -499,241 | 0.05 | 0.02 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 1,855,158 | 1,768,499 | -86,659 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 1,513,058 | +1,513,058 | 0.00 | 0.14 | +0.14 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,435,931 | 1,442,841 | +6,910 | 3.29 | 1.65 | -1.64 | buy |
| TWO SIGMA ADVISERS, LP | 1,312,200 | 1,391,900 | +79,700 | 0.02 | 0.01 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 510,315 | 1,362,216 | +851,901 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,171,840 | 1,307,733 | +135,893 | 0.02 | 0.01 | -0.01 | buy |
| TCG Crossover Management, LLC | 1,276,574 | 1,276,574 | 0 | 0.82 | 0.61 | -0.21 | hold |
| ArrowMark Colorado Holdings LLC | 1,291,939 | 1,244,358 | -47,581 | 0.12 | 0.07 | -0.05 | sell |
| MORGAN STANLEY | 514,183 | 1,137,938 | +623,755 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,142,210 | 1,111,910 | -30,300 | 0.75 | 0.56 | -0.19 | sell |
| GOLDMAN SACHS GROUP INC | 1,281,242 | 737,835 | -543,407 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 632,091 | 619,112 | -12,979 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 764,862 | 560,959 | -203,903 | 0.07 | 0.04 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 575,131 | 509,406 | -65,725 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 267,429 | 488,958 | +221,529 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 405,885 | +405,885 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 696,677 | 404,118 | -292,559 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 334,518 | 373,657 | +39,139 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 496,543 | 356,212 | -140,331 | 0.01 | 0.00 | -0.00 | sell |
| Atom Investors LP | 316,246 | 332,620 | +16,374 | 0.32 | 0.15 | -0.17 | buy |
| Point72 Asset Management, L.P. | 906,472 | 278,580 | -627,892 | 0.02 | 0.00 | -0.02 | sell |
| Qube Research & Technologies Ltd | 388,193 | 258,426 | -129,767 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 405,800 | 235,200 | -170,600 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 197,109 | 229,345 | +32,236 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 116,507 | 223,200 | +106,693 | 0.03 | 0.02 | -0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 76,791 | 220,517 | +143,726 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 0.09 | +0.09 | buy |
| Bank of New York Mellon Corp | 0 | 190,761 | +190,761 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 833,681 | 185,738 | -647,943 | 0.03 | 0.00 | -0.02 | sell |
| NORTHERN TRUST CORP | 108,678 | 179,573 | +70,895 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 53,093 | 175,911 | +122,818 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 142,832 | +142,832 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 54,114 | 131,866 | +77,752 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 51,365 | 129,801 | +78,436 | 0.02 | 0.01 | -0.01 | buy |
| Mariner, LLC | 128,037 | 127,879 | -158 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 224,487 | 118,473 | -106,014 | 0.04 | 0.01 | -0.03 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 21,993 | 113,436 | +91,443 | 0.00 | 0.00 | +0.00 | buy |
| Arete Wealth Advisors, LLC | 85,200 | 111,300 | +26,100 | 0.06 | 0.04 | -0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 88,850 | 110,075 | +21,225 | 0.00 | 0.00 | -0.00 | buy |
| M&T BANK CORP | 84,810 | 95,441 | +10,631 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 1,791 | 90,621 | +88,830 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.27 | 0.15 | -0.12 | hold |
| Invesco Ltd. | 38,536 | 65,499 | +26,963 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,115,477 | 62,307 | -2,053,170 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 57,600 | 57,600 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Alpine Global Management, LLC | 0 | 57,528 | +57,528 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 136,827 | 57,117 | -79,710 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49,000 | 49,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 0 | 45,780 | +45,780 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 487,651 | 44,030 | -443,621 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 49,269 | 42,101 | -7,168 | 0.01 | 0.01 | -0.01 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 42,000 | +42,000 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 52,304 | 39,976 | -12,328 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 39,002 | 38,097 | -905 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 126,250 | 34,149 | -92,101 | 0.04 | 0.01 | -0.03 | sell |
| Brevan Howard Capital Management LP | 15,526 | 33,511 | +17,985 | 0.01 | 0.01 | -0.00 | buy |
| Corton Capital Inc. | 0 | 31,959 | +31,959 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 770,728 | 30,456 | -740,272 | 0.01 | 0.00 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 0 | 29,848 | +29,848 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 20,012 | 29,077 | +9,065 | 0.00 | 0.00 | -0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 28,000 | 28,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 27,136 | +27,136 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 25,761 | +25,761 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 23,700 | +23,700 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 37,288 | 23,627 | -13,661 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 48,763 | 23,268 | -25,495 | 0.03 | 0.01 | -0.02 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 23,228 | +23,228 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,218 | 22,918 | -49,300 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,913 | 21,844 | +14,931 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 1,400 | 20,700 | +19,300 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 19,735 | +19,735 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 19,300 | +19,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 15,477 | +15,477 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 41,732 | 14,973 | -26,759 | 0.07 | 0.01 | -0.06 | sell |
| CAPTRUST FINANCIAL ADVISORS | 14,822 | 14,822 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marathon Trading Investment Management LLC | 64,000 | 14,400 | -49,600 | 0.21 | 0.02 | -0.19 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 12,937 | +12,937 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 12,695 | 12,695 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 12,025 | +12,025 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 39,396 | 11,280 | -28,116 | 0.02 | 0.00 | -0.02 | sell |
| B. Riley Wealth Advisors, Inc. | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 10,162 | +10,162 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 0 | 9,652 | +9,652 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,744 | +5,744 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 5,063 | +5,063 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 4,248 | +4,248 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 2,029 | +2,029 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,735 | +1,735 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 3,929 | 1,056 | -2,873 | 0.00 | 0.00 | -0.00 | sell |
| SYNTAX RESEARCH, INC. | 1,000 | 1,000 | 0 | 0.01 | 0.00 | -0.00 | hold |